A5041518059- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Electrolyte and hormonal disorders
- Growth Hormone and Insulin-like Growth Factors
- Oxidative Organic Chemistry Reactions
- Ultrasound and Hyperthermia Applications
- Cell Adhesion Molecules Research
- Organ Transplantation Techniques and Outcomes
- 14-3-3 protein interactions
- Adolescent and Pediatric Healthcare
- Adipokines, Inflammation, and Metabolic Diseases
- Reproductive Physiology in Livestock
- Birth, Development, and Health
- Healthcare Systems and Technology
- Advanced Biosensing Techniques and Applications
- Ovarian cancer diagnosis and treatment
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Liver Disease and Transplantation
- Adipose Tissue and Metabolism
- Microbial Natural Products and Biosynthesis
- Cardiovascular Function and Risk Factors
- Autoimmune and Inflammatory Disorders Research
- Atherosclerosis and Cardiovascular Diseases
Manchester University NHS Foundation Trust
2020-2021
Manchester Academic Health Science Centre
2017-2021
Manchester Royal Infirmary
2018
University of Nottingham
2013
University of Glasgow
2013
Maine Farmland Trust
2013
University Hospital Limerick
2013
University College London
2013
Objectives The aim of the current study was to compare levels vascular cell adhesion molecule-1 (VCAM-1) and E-selectin in lupus patients controls investigate their association with clinical phenotype, disease activity damage. Methods We compared serum VCAM-1 178 female 69 age-and sex-matched controls. Using linear regression we also examined between these markers activity, damage, renal skin involvement as well subclinical cardiovascular disease. Results increased (median (IQR) 10.5 (6.85,...
In rheumatoid arthritis (RA), chronic inflammation is thought to drive increased cardiovascular risk through accelerated atherosclerosis. It may also lead a more high-risk plaque phenotype. We sought investigate carotid phenotype in RA patients using Dynamic Contrast-Enhanced MRI (DCE-MRI) and Fludeoxyglucose Positron Emission Tomography(FDG-PET). this pilot study, age/sex-matched controls were evaluated for factors on ultrasound. Subjects with >2 mm thick underwent DCE-MRI, subgroup of had...
The use of Human Epididymis Protein 4 (HE4) as a biomarker for ovarian cancer is gaining traction, providing the impetus development high throughput automated HE4 assay that comparable to conventional manual enzyme immunometric-assay (EIA). aim this study was compare two immunoassay methods measurement serum HE4. 1348 samples were analysed using both EIA and chemiluminescent (CLEIA) methods. values compared Passing-Bablok regression agreement assessed Lin's concordance correlation...
The positions of labelled atoms in fusicoccin biosynthesised from [1-13C]- and [2-13C]-acetate have been determined by 13C n.m.r. spectroscopy. results are consistent with being formed direct cyclisation a precursor such as geranylgeraniol pyrophosphate.
Background: Rheumatoid arthritis (RA) causes progressive joint damage and functional disability. Studies on factors affecting as clinical outcome are lacking in Africa. The aim of the present study was to identify predictors adult South Africans with established RA.
Objectives: Vascular dysfunction is common in obesity. Insulin can directly modulate arterial function, but its role unclear We examined the influence of adiposity on direct effects insulin human artery responses. Methods: 22 healthy women were stratified by median BMI into lower (LA) (n=11) and higher (HA) (n=11). Small arteries from gluteal biopsies tested for contractile responses to Noradrenaline (NA), endothelium-dependent dilator Carbachol endothelium-independent sodium nitroprusside...
<h3>Background</h3> Monitoring SLE disease activity either globally or within individual organ systems is based on scoring methods and serological tests. Specific biomarkers to enhance improve follow-up have been examined. Animal human studies proposed that monocyte chemoattractant protein 1 (MCP1) has a role in renal damage nephritis SLE. Studies also linked increased urinary MCP1 (uMCP1) levels with active the severity of nephritis. Although albumin (uAlb) are limited, microalbuminuria...