A5011814262- Retinal Diseases and Treatments
- Advanced Fluorescence Microscopy Techniques
- Retinal Development and Disorders
- Zebrafish Biomedical Research Applications
- Axon Guidance and Neuronal Signaling
- Modular Robots and Swarm Intelligence
- Cellular Mechanics and Interactions
- Ferroptosis and cancer prognosis
- Data-Driven Disease Surveillance
- Angiogenesis and VEGF in Cancer
- Cellular Automata and Applications
- Bioinformatics and Genomic Networks
- Renal cell carcinoma treatment
- Scientific Computing and Data Management
- Hippo pathway signaling and YAP/TAZ
- COVID-19 Digital Contact Tracing
- COVID-19 epidemiological studies
- Single-cell and spatial transcriptomics
The Francis Crick Institute
2019-2024
King's College London
2020-2021
King's College - North Carolina
2020
SARS-CoV-2 has spread across the world, causing high mortality and unprecedented restrictions on social economic activity. Policymakers are assessing how best to navigate through ongoing epidemic, with computational models being used predict of infection assess impact public health measures. Here, we present OpenABM-Covid19: an agent-based simulation epidemic including detailed age-stratification realistic networks. By default model is parameterised UK demographics calibrated however, it can...
As the general population ages, more people are affected by eye diseases, such as retinopathies. It is therefore critical to improve imaging of disease mouse models. Here, we demonstrate that 1) rapid, quantitative 3D and 4D (time lapse) cellular subcellular processes in feasible, with without tissue clearing, using light-sheet fluorescent microscopy (LSFM); 2) flat-mounting retinas for confocal significantly distorts morphology, confirmed correlative LSFM-Confocal vessels; 3) LSFM readily...
How do cells make efficient collective decisions during tissue morphogenesis? Humans and other organisms use feedback between movement sensing known as ‘sensorimotor coordination’ or ‘active perception’ to inform behaviour, but active perception has not before been investigated at a cellular level within organs. Here we provide the first proof of concept in silico / vivo study demonstrating that filopodia (actin-rich, dynamic, finger-like cell membrane protrusions) play an unexpected role...
Abstract As the general population ages and incidence of diabetes increases epidemically, more people are affected by eye diseases, such as retinopathies. It is therefore critical to improve imaging disease mouse models. Here, we demonstrate that 1) rapid, quantitative 3D 4D (time lapse) cellular subcellular processes in murine feasible, with without tissue clearing, using light-sheet fluorescent microscopy (LSFM) 2) LSFM readily reveals new features even well studied models, Oxygen-Induced...
Abstract Clear cell Renal Cell Carcinoma (ccRCC) is profoundly angiogenic, characterised by complex yet heterogenous vascular networks. Blood vessels are an important constituent part of the tumour microenvironment (TME) and, in addition to immune cells, target drug therapies advanced disease. The TME plays role determining disease progression and response therapy, acting as a selective pressure on cells thus influencing evolutionary trajectory. This sculpted cross-talk between blood...
Abstract How do cells make efficient collective decisions during tissue morphogenesis? Humans and other organisms utilize feedback between movement sensing known as ‘sensorimotor coordination’ or ‘active perception’ to inform behaviour, but active perception has not before been investigated at a cellular level within organs. Here we provide the first proof of concept in silico/in vivo study demonstrating that filopodia (actin-rich, dynamic, finger like cell-membrane protrusions) play an...
The study of morphogenesis has increasingly entailed the use computer simulations to predict intricate behaviours from these systems, which led development tools for computational biologists build their own simulations. However, uptake by experimental been slow and concerns remain over assumptions underlying such tools, are not readily explicable a domain expert without prior programming knowledge. To demonstrate how might be addressed, we propose creation domain-specific language (DSL) one...