A5055270569- Computational Drug Discovery Methods
- Luminescence and Fluorescent Materials
- Carbohydrate Chemistry and Synthesis
- Cholinesterase and Neurodegenerative Diseases
- Molecular Sensors and Ion Detection
- Supramolecular Chemistry and Complexes
- Tryptophan and brain disorders
- Pneumonia and Respiratory Infections
- Lysosomal Storage Disorders Research
- Treatment of Major Depression
- Glycosylation and Glycoproteins Research
- Alzheimer's disease research and treatments
- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- Synthesis of β-Lactam Compounds
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Antiplatelet Therapy and Cardiovascular Diseases
- Natural Compounds in Disease Treatment
- Pharmacological Receptor Mechanisms and Effects
- Neuroscience and Neuropharmacology Research
University of Chile
2020-2022
Instituto de Ciências Farmacêuticas
2020
Universidad de Sevilla
2014-2019
Rede de Química e Tecnologia
2014
Efficient delivery of pharmacological chaperones for Gaucher disease to macrophages has been achieved.
An increasing number of pathologies have been linked to Toll-like receptor 4 (TLR4) activation and signaling, therefore new hit lead compounds targeting this process are urgently needed. We report on the synthesis biological properties glycolipids based glucose trehalose scaffolds which potently inhibit TLR4 signaling in vitro vivo. Structure-activity relationship studies these indicate that presence fatty ester chains molecule is a primary prerequisite for activity point facial...
This article reports the synthesis and characterisation of two lower rim calix[4]arene derivatives with thiourea as spacer pyrene or methylene-pyrene fluorophore.
Trehalose Siamese twin vectors, encompassing gemini and facial amphiphilicity, promote pDNA compaction into core–shell nanocomplexes selective delivery in the lungs.
A series of 27 compounds general structure 2,3-dihydro-benzo[1,4]oxazin-4-yl)-2-{4-[3-(1H-3indolyl)-propyl]-1-piperazinyl}-ethanamides, Series I: 7(a–o) and (2-{4-[3-(1H-3-indolyl)-propyl]-1-piperazinyl}-acetylamine)-N-(2-morfolin-4-yl-ethyl)-fluorinated benzamides II: 13(a–l) were synthesized evaluated as novel multitarget ligands towards dopamine D2 receptor, serotonin transporter (SERT), monoamine oxidase-A (MAO-A) directed to the management major depressive disorder (MDD). All assayed...
A new selective fluorogenic chemosensor for Hg2+, which combines a calixarene derivative with BODIPY core as fluorescent reporter, is described. The remarkable change in its properties DMSO and CHCl3 has been analyzed. study of spectral on dilution, along molecular modeling studies, allowed us to explain that this behavior involves the formation J-dimer, well how sensing mechanism Hg2+ proceeds.