A5008751915- Regulation of Appetite and Obesity
- Zebrafish Biomedical Research Applications
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- Neurogenesis and neuroplasticity mechanisms
- RNA and protein synthesis mechanisms
- Alzheimer's disease research and treatments
- melanin and skin pigmentation
- Nerve injury and regeneration
- RNA Research and Splicing
- Parkinson's Disease Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
Institute of Cytology and Genetics
2022-2025
Tryptophan hydroxylase 2 (TPH2) hydroxylates L-tryptophan to L-5-hydroxy tryptophan-the key step of 5-HT synthesis in the mammalian brain. Some mutations human hTPH2 gene are associated with psychopathologies and resistance antidepressant therapy. The C1473G polymorphism mouse Tph2 decreases TPH2 activity In present paper, B6-1473C B6-1473G congenic mice that were different only C > G substitution used. molecular mechanism decrease mutant enzyme some physiological behavioral traits affected...
Tryptophan hydroxylase 2 (TPH2) is the key and rate-limited enzyme of serotonin (5-HT) synthesis in brain. The C1473G mutation Tph2 gene results a two-fold decrease activity mouse lethal yellow (AY) Raly-Agouti locus overexpression Agouti brain causes obesity depressive-like behavior mice. Herein, possible influences these mutations their combination on body mass, behavior, 5-HT melanocortin systems mice B6-1473CC/aa. B6-1473CC/AYa, B6-1473GG/aa are investigated. B6-1473GG/AYa genotypes were...
Parkinson’s disease (PD) is the most common age-related movement disorder characterized by progressive loss of nigrostriatal dopaminergic neurons. To date, PD treatment strategies are mostly based on dopamine replacement medicines, which can alleviate motor symptoms but do not slow down progression neurodegeneration. Thus, there a need for disease-modifying therapies. The aim this work was to evaluate neuroprotective effects novel compound PA96 neurons in vivo and vitro, assess its ability...
The brain melanocortin system regulates numerous physiological functions and kinds of behavior. agouti protein inhibits receptors in melanocytes. lethal yellow (AY) mutation puts the Agouti gene under control Raly promotor causes expression brain. In present article, we investigated effects AY on mRNA levels Agouti, Raly, melanocortin-related genes such as Agrp, Pomc, Mc3r, Mc4r, their relationship to behavior.The experiment was performed 6-month-old males females AY/a a/a (control) mice....