A5110447257- Escherichia coli research studies
- Parasitic infections in humans and animals
- Cancer Research and Treatments
- Bacterial Genetics and Biotechnology
- Peripheral Neuropathies and Disorders
- Autophagy in Disease and Therapy
- Ophthalmology and Eye Disorders
- Ureteral procedures and complications
- Infectious Diseases and Tuberculosis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Emergency and Acute Care Studies
- Cervical Cancer and HPV Research
- Reproductive System and Pregnancy
- Polyomavirus and related diseases
- Central Venous Catheters and Hemodialysis
- Cardiac Arrest and Resuscitation
- Endoplasmic Reticulum Stress and Disease
- Rheumatoid Arthritis Research and Therapies
- Cytomegalovirus and herpesvirus research
- Injury Epidemiology and Prevention
- Diabetes Management and Research
- CRISPR and Genetic Engineering
- Acute Kidney Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Bacterial Infections and Vaccines
Imperial College London
2020-2022
Northwick Park Hospital
2015-2020
National Hospital for Neurology and Neurosurgery
2017
University College London
2017
London North West Healthcare NHS Trust
2016
Queen Mary University of London
2015
University of Oxford
2010-2013
Birmingham Children's Hospital
2013
Sydney Children's Hospital
2003
The University of Sydney
2003
Despite an increasing awareness of the importance innate immunity, roles natural killer (NK) cells in transplant rejection and antiviral cancer immunity during immunosuppression have not been clearly defined.To address this issue we developed a quantitative assay NK cell function that can be used on clinical samples studied influence function. degranulation intracellular interferon (IFN)-γ production were determined by flow cytometry peripheral blood samples.Overnight ex vivo treatment from...
Clinical heterogeneity in multiple sclerosis is the rule. Evidence suggests that HLA-DRB1*15 may play a role clinical outcome. Spinal cord pathology common and contributes significantly to disability disease. The influence of on spinal unknown. A post-mortem cohort pathologically confirmed cases with (n = 108, 34 males) fresh frozen material available for genetic analyses fixed was used. HLA-DRB1 alleles were genotyped select subset age- sex-matched HLA-DRB1*15-positive 21) negative 26)...
The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through ubiquitination cytoplasmic tail mMHCII β chain. Here, a genome-wide mutant screen human cells, we show that NEDD4 family HECT E3 ubiquitin ligase WWP2 and tumor-suppressing transmembrane protein unknown biochemical function, TMEM127, are required for SteD-dependent mMHCII. Although evidently not involved in normal regulation mMHCII, TMEM127 was...
The NEDD4-like E3 ubiquitin ligase, WWP2, is involved in a range of host processes from cell differentiation to T immunity. Ligase activity tightly regulated with WWP2 being held an autoinhibited state. Binding PY motif containing adaptor, Ndfip, via the WW domains ligases leads their disinhibition. Here, we show that canonical NDFIP2, requires multiple motifs for interaction and activation WWP2. In contrast, single PY-motif Ndfips TMEM127 SUSD6 function as co-disinhibitory pair. Salmonella...
SteD is a transmembrane effector of the Salmonella SPI-2 type III secretion system that inhibits T cell activation by reducing amounts at least three proteins -major histocompatibility complex II (MHCII), CD86 and CD97 -from surface antigen-presenting cells. specifically localises trans-Golgi network (TGN) MHCII compartments; however, targeting, membrane integration trafficking are not understood. Using systematic mutagenesis, we identify distinct regions required for these processes. We...
A 57-year-old woman was referred to the breast clinic with a 3-week history of painful and swollen left breast. She otherwise completely well had no significant medical history. born in Nepal moved United Kingdom 12 years previously. Her last visit been 1 year before presentation. On examination, there mass palpable Full blood count differential were within normal limits. Mammography showed 9-mm asymmetry breast, 97 mm from nipple 6 o'clock position, indeterminate for malignancy (Figure 1)....
OBJECTIVE: To evaluate the influence of HLA-DRB1*15 on multiple sclerosis spinal cord pathology.
<h3></h3> Acute meningococcal meningitis in adults can be complicated by cranial neuropathies and more rarely myelopathy. A 55-year-old woman presented with acute bacterial requiring intubation was treated intravenous antibiotics dexamethasone. Cerebrospinal fluid 16S PCR positive for Neisseria meningitidis latex agglutination confirmed the W135 serotype. Ten days after presentation she developed mild upper limb severe lower weakness hyperreflexia, despite resolution of meningism improvement...
Abstract SteD is a transmembrane effector of the Salmonella SPI-2 type III secretion system that inhibits T cell activation by reducing amounts at least three proteins – major histocompatibility complex II (MHCII), CD86 and CD97 from surface antigen-presenting cells. specifically localises trans -Golgi network (TGN) MHCII compartments; however, targeting, membrane integration trafficking are not understood. Using systematic mutagenesis, we identify distinct regions required for these...