A5019712612- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Sports Performance and Training
- Stroke Rehabilitation and Recovery
- Acne and Rosacea Treatments and Effects
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Cerebral Palsy and Movement Disorders
- Retinopathy of Prematurity Studies
- Sports injuries and prevention
- melanin and skin pigmentation
- Balance, Gait, and Falls Prevention
- vaccines and immunoinformatics approaches
- Urticaria and Related Conditions
- Silk-based biomaterials and applications
- Chemokine receptors and signaling
- Retinoids in leukemia and cellular processes
- PI3K/AKT/mTOR signaling in cancer
- Dermatologic Treatments and Research
- Liver Disease Diagnosis and Treatment
- Menstrual Health and Disorders
Second Affiliated Hospital of Zhejiang University
2021-2025
Universiti Putra Malaysia
2024-2025
National Clinical Research Center for Digestive Diseases
2025
Capital Medical University
2025
Beijing Friendship Hospital
2025
Minzu University of China
2025
Anhui Medical University
2024
Tianjin University of Traditional Chinese Medicine
2023-2024
Central South University
2024
People's Liberation Army 401 Hospital
2023
Bone is one of the most common sites tumor metastases. During last step bone metastasis, cancer cells colonize and disrupt matrix, which maintained mainly by osteocytes, abundant in microenvironment. However, role osteocytes metastasis still unclear. Here, we demonstrated that transfer mitochondria to metastatic trigger cGAS/STING-mediated antitumor response. Blocking specifically knocking out mitochondrial Rho GTPase 1 ( Rhot1 ) or mitofusin 2 Mfn2 impaired immunogenicity consequently...
Structural docking between the adaptive immune receptors (AIRs), including T cell (TCRs) and B (BCRs), their cognate antigens are one of most fundamental processes in immunity. However, current methods for predicting AIR-antigen binding largely rely on sequence-derived features AIRs, omitting structure that essential affinity. In this study, we present a deep learning framework, termed DeepAIR, accurate prediction by integrating both sequence AIRs. DeepAIR achieves Pearson's correlation...
Chitosan/siRNA nanoparticles to knock down FHL2 gene expression were reported in this work. The physicochemical properties such as particle size, surface charge, morphology and complex stability of chitosan nanoparticle-incorporated siRNA evaluated. Nanoparticles which formulated with chitosan/siRNA exhibited irregular, lamellar dendritic structures a hydrodynamic radius size about 148 nm net positive charges zeta-potential value 58.5 mV. knockdown effect the on over-expressed human...
<title>Abstract</title> Psoriasis is a chronic, complex immune-mediated inflammatory disorder with cutaneous and systemic manifestations in which keratinocytes, dendritic cells T have central roles. UBE2L3 may be protective biomarker that regulates the pathogenesis of psoriasis. Here, we identified IL-17A signaling similarity between human psoriatic skin <italic>Ube2l3</italic> conditional knockout mouse epidermis rather than dermis. was regulated by CXCR6<sup>+</sup> Vγ2<sup>+ </sup>γδT...
The Isoleucyl-tRNA synthetase (IARS) catalyzes isoleucine to the corresponding tRNA, maintaining accuracy of gene translation. Its role in psoriasis has been not investigated so far. In this study, we aimed investigate mechanisms underlying efficacy IARS inhibitor, mupirocin, treatment for psoriasis.The expression was determined by immunofluorescence, Western blot and qRT-PCR normal healthy control- psoriatic human skin. An imiquimod (IMQ) -induced psoriasis-like skin disease model used...
Atopic dermatitis (AD) is one of the most common inflammatory skin diseases with complex pathogenesis involving epidermal barrier dysfunction, microbiome abnormalities and type-2-skewed immune dysregulation. Signal transducer activator transcription 3 (STAT3) a factor that plays critical roles in various biological processes. However, role STAT3 keratinocytes AD remains unclear. In this study, we generated an keratinocyte-specific Stat3 -deficient mouse strain (termed cKO mice). After...
Introduction: Hepatocellular carcinoma (HCC) is a global health problem with increasing morbidity and mortality, exploring the diagnosis treatment of HCC at gene level has been research hotspot in recent years. Methods: In this paper, series differentially expressed genes were found from biochip related to by bioinformatic analysis, then CNDP1 was finally selected for in-depth study according function progress each gene. As rate-limiting enzyme carnosine hydrolysis, participates many...
Psoriasis is an immune-mediated skin disease dominated by the cutaneous immune system. Keratinocytes have been considered important triggers that initiate psoriasis. The key molecules and events of keratinocytes link innate system in psoriasis must be investigated more detail. Human primary human keratinocyte were detected vitro. Epidermis specific transgenic mouse strain (Krt14-Sprouty1 tg) was used to further investigate psoriasis-like inflammation vivo.Bulk RNA sequencing screened...
This study undertakes a comprehensive comparison of five different interventions for the treatment type-1 retinopathy prematurity (ROP) and aggressive posterior ROP (APROP), offering insights into their relative efficacies contributing to better clinical decision making. The aim this was compare efficacy intravitreal aflibercept (IVA), bevacizumab (IVB), conbercept (IVC), ranibizumab (IVR), laser therapy in treating these conditions. We conducted search relevant randomized controlled trials...