A5046701532- Pharmacological Effects and Toxicity Studies
- Meta-analysis and systematic reviews
- Ethics in Clinical Research
- Virology and Viral Diseases
- Analytical Methods in Pharmaceuticals
- HIV/AIDS Research and Interventions
- Hepatitis B Virus Studies
- Nitric Oxide and Endothelin Effects
- Statistical Methods in Clinical Trials
- Advanced Adaptive Filtering Techniques
- Chemical synthesis and pharmacological studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Hemoglobinopathies and Related Disorders
- Patient-Provider Communication in Healthcare
- Digital Imaging for Blood Diseases
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Drug Transport and Resistance Mechanisms
- Image and Signal Denoising Methods
- Digital Filter Design and Implementation
- Antibiotics Pharmacokinetics and Efficacy
- Chemical Reaction Mechanisms
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
University College London
1996-2019
MRC Clinical Trials Unit at UCL
2016-2019
Medical Research Council
2016
National Institute of Technology Durgapur
2013
Universidad de Londres
1997
University of London
1995-1997
King's College London
1995-1997
In this paper, opposition‐based harmony search has been applied for the optimal design of linear phase FIR filters. RGA, PSO, and DE have also adopted sake comparison. The original algorithm is chosen as parent one, approach applied. During initialization, randomly generated population solutions chosen, opposite are considered, fitter one selected a priori guess. memory, each such solution passes through memory consideration rule, pitch adjustment then reinitialization generation jumping,...
Background/aims In multi-site clinical trials, where trial data and conduct are scrutinised centrally with pre-specified triggers for visits to sites, targeted monitoring may be an efficient way prioritise on-site monitoring. This approach is widely used in academic but has never been formally evaluated. Methods TEMPER assessed the ability of monitoring, as three ongoing phase III randomised oncology distinguish sites at which higher lower rates protocol and/or Good Clinical Practice...
For human immunodeficiency virus (HIV)-infected adolescents facing lifelong antiretroviral therapy (ART), short-cycle (SCT) with long-acting agents offers the potential for drug-free weekends, less toxicity, better adherence and cost savings. To determine whether or not efavirenz (EFV)-based ART in short cycles of 5 days on 2 off is as efficacious (in maintaining virological suppression) continuous EFV-based (continuous therapy; CT). Secondary objectives included occurrence new clinical HIV...
Triggered monitoring in clinical trials is a risk-based approach where triggers (centrally monitored, predefined key risk and performance indicators) drive the extent, timing, frequency of visits. The TEMPER study used prospective, matched-pair design to evaluate use triggered strategy, comparing findings from visits with those matched control sites. To facilitate this study, we developed bespoke system: Management System. System comprises web application (the front end), an SQL server...
Three orally active iron chelating agents from the 3-hydroxypyridin-4-one series of compounds were administered by gavage to both normal and iron-overloaded (500 mg Fe/kg) rats at a dose 450 mumol/kg investigate effect loading on metabolism urinary recovery. Compounds selected for investigation either poorly metabolized [1-(2'-hydroxyethyl) derivative, CP102] or predominantly biotransformed phase I [1,2-diethyl CP94] II (1,2-dimethyl CP20) metabolic pathways. Unchanged drug metabolite(s)...