A5059993749- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Advanced Electron Microscopy Techniques and Applications
- RNA modifications and cancer
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2020-2023
Polish Academy of Sciences
2020-2023
Abstract High‐grade gliomas are aggressive, deadly primary brain tumors. Median survival of patients with glioblastoma (GBM, WHO grade 4) is 14 months and <10% survive 2 years. Despite improved surgical strategies forceful radiotherapy chemotherapy, the prognosis GBM poor did not improve over decades. We performed targeted next‐generation sequencing a custom panel 664 cancer‐ epigenetics‐related genes, searched for somatic germline variants in 180 different grades. Herein, we focus on 135...
Abstract Background High grade gliomas (HGGs) are aggressive, primary brain tumors with poor clinical outcomes. We aim to better understand glioma pathobiology and find potential therapeutic susceptibilities. Methods designed a custom panel of 664 cancer- epigenetics-related genes, employed targeted next generation sequencing study the genomic landscape somatic germline variants in 182 different malignancy grades. mRNA was performed detect transcriptomic abnormalities. Results In addition...