A5057258884- Nanoparticles: synthesis and applications
- Environmental Toxicology and Ecotoxicology
- Microplastics and Plastic Pollution
- Electrochemical Analysis and Applications
- Heavy metals in environment
- Nanoparticle-Based Drug Delivery
- Advanced Chemical Sensor Technologies
- Electrohydrodynamics and Fluid Dynamics
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Nanomaterials for catalytic reactions
- Ecosystem dynamics and resilience
- Graphene and Nanomaterials Applications
- Extraction and Separation Processes
- Microfluidic and Bio-sensing Technologies
- Geochemistry and Elemental Analysis
- Protease and Inhibitor Mechanisms
- Innovative Microfluidic and Catalytic Techniques Innovation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Analytical chemistry methods development
- 3D Printing in Biomedical Research
- Cell Image Analysis Techniques
University of Science and Technology of China
2024
University of Birmingham
2016-2023
The aquatic ecosystem is the final destination of most industrial residues and agrochemicals resulting in organisms being exposed to a complex mixture contaminants. Nanomaterials (NMs) are increasingly applied many technologies sectors, so there an increasing concern about negative impacts NMs environment after their interaction with co-contaminants. Consequently, toxicology has been gaining attention nanotoxicology recently. Usually, toxicity or combined estimated from individual effects...
The sonication process is commonly used for de-agglomerating and dispersing nanomaterials in aqueous based media, necessary to improve homogeneity stability of the suspension. In this study, a systematic step-wise approach carried out identify optimal conditions order achieve stable dispersion. This has been adopted shown be suitable several (cerium oxide, zinc carbon nanotubes) dispersed deionized (DI) water. However, with any change either nanomaterial type or medium, there needs...
Abstract This study presents the results of applying deep learning methodologies within ecotoxicology field, with objective training predictive models that can support hazard assessment and eventually design safer engineered nanomaterials (ENMs). A workflow two different architectures on microscopic images Daphnia magna is proposed automatically detect possible malformations, such as effects length tail, overall size, uncommon lipid concentrations deposit shapes, which are due to direct or...
Understanding the environmental behaviour of nanoparticles (NPs) after release into aquatic systems is essential to predict implications nanotechnology. Silver (AgNPs) represent a major class engineered NPs with significant potential for impact. Therefore, investigating their transformations in natural waters will help long term fate and behaviour. AgNPs were characterized lake water collected seasonally from same freshwater source, using column microcosms assess transport at different...
Abstract Engineered nanoparticles (NPs) undergo physical, chemical, and biological transformation after environmental release, resulting in different properties of the “aged” versus “pristine” forms. While many studies have investigated ecotoxicological effects silver (Ag) NPs, majority focus on Ag NPs simple exposure media, rather than investigating realistic scenarios with transformed NPs. Here, are systematically evaluated surface coatings Daphnia magna over four generations, comparing...
Nanoinformatics models to predict the toxicity/ecotoxicity of nanomaterials (NMs) are urgently needed support commercialization nanotechnologies and allow grouping NMs based on their physico-chemical and/or (eco)toxicological properties, facilitate read-across knowledge from data-rich data-poor ones. Here we present first ecotoxicological for predicting ecotoxicity, which were developed in accordance with ECHA's recommended strategy as a means explore silico effects panel freshly dispersed...
Pristine engineered nanomaterials (NMs) entering the aquatic environment become ‘aged’ during their lifetime <italic>via</italic> chemical, physical and/or biological process.
Despite broad application of magnetic nanoparticles in biomedicine and electronics, only a few vivo studies on biocompatibility are available. In this study, toxicity metal oxide the respiratory system was examined by single intratracheal instillation mice. Bronchoalveolar lavage fluid (BALF) samples were collected for proteome analyses LC–MS/MS, testing Fe3O4 doped with increasing amounts cobalt (Fe3O4, CoFe2O4 an iron to ratio 5:1, 3:1, 1:3, Co3O4) at two doses (54 μg, 162 μg per animal)...
Secreted corona composition of Ag and TiO<sub>2</sub> NMs, evaluated after 7 days continuous exposure to daphnids, provides important insights into the biological pathways perturbed by NMs.
Evaluation of the uptake pathways in cells during exposure to nanoparticles (NPs) is key for risk assessment and development safer nanomaterials, as internalisation fate NPs linked their toxicity mode action. Here, we determined mechanisms activated 10, 30, 100 nm AgNPs by embryonic zebrafish (ZF4). The results demonstrated an NP size- time-dependent uptake, showing highest total silver smallest AgNP (10 nm) at lowest concentration (2.5 μg/mL) after 2 h, while 24 10 revealed cellular load 8...
The sonication process is commonly used for de-agglomerating and dispersing nanomaterials in aqueous based media, necessary to improve homogeneity stability of the suspension. In this study, a systematic step-wise approach carried out identify optimal conditions order achieve stable dispersion. This has been adopted shown be suitable several (cerium oxide, zinc carbon nanotubes) dispersed deionized (DI) water. However, with any change either nanomaterial type or medium, there needs...
There is increasing recognition that environmental nano-biological interactions in model species, and the resulting effects on progeny, are of paramount importance for nanomaterial (NM) risk assessment. In this work, Daphnia magna F0 mothers were exposed to a range silver titanium dioxide NMs. The key biological life history traits (survival, growth reproduction) F1 intergenerations, at first (F1B1), third (F1B3) fifth (F1B5) broods, investigated. Furthermore, germlines each three broods...
The reliable quantification of nanomaterials (NMs) in complex matrices such as food, cosmetics and biological environmental compartments can be challenging due to interactions with matrix components analytical equipment (vials tubing). resulting losses along the process (sampling, extraction, clean-up, separation detection) hamper target NMs these well compatibility results meaningful interpretations safety assessments. These issues overcome by addition known amounts internal/recovery...
Despite their ubiquity in personal care products, the health implications of titanium dioxide (TiO 2 ) nanomaterials (NMs) are under strenuous investigation for potential as a carcinogen, whereas other evidence has shown links with premature ageing. Both hazards manifested after chronic exposure. To explore effects TiO NMs environment, multigenerational study using model test species Daphnia magna is conducted. Phenotypical characteristics associated ageing observed (loss or shortening tails...
The environmental risks of SiNP reported in the literature are contradictory and bring into question its safety for use consumer applications. Organisms never exposed to NPs alone real environment, while studies combined toxicity limited. To address this, we compared acute fluorescent core-shell SiNPs mixtures with Cd2+ Ceriodaphnia dubia absence presence NOM. We identified biodistribution feeding behaviour addition traditional endpoints. NOM increased colloidal stability reconstituted...