A5074775651- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Pharmacological Effects and Toxicity Studies
- Receptor Mechanisms and Signaling
- Estrogen and related hormone effects
- HIV/AIDS drug development and treatment
- Biochemical effects in animals
- Aldose Reductase and Taurine
- Synthesis and biological activity
- Neuroinflammation and Neurodegeneration Mechanisms
- Histone Deacetylase Inhibitors Research
- Synthesis and Characterization of Heterocyclic Compounds
- Free Radicals and Antioxidants
Instituto Politécnico Nacional
2011-2023
During the inflammation process, myeloperoxidase (MPO) contributes to production of reactive species mainly for destruction pathogens. When is dysregulated, overproduction generates cellular damage via oxidation biomolecules (proteins, lipids and nucleic acids) that are associated with many acute or chronic inflammatory diseases, including cardiovascular neurodegenerative disorders, dermatitis, ulcerative colitis, cancer. Therefore, MPO plays a crucial role in oxidative stress, representing...
Oxidative stress is related to the pathogenesis and progress of several human diseases. NADPH oxidase (NOX), mainly NOX2 isoform, produces superoxide anions (O 2 • − ). To date, it known that can be inhibited by preventing assembly its subunits, p47phox p22phox. In this work, we analyzed binding apocynin dimer, diapocynin ( C1 ), a inhibitor, 18 designed compounds C2 – C19 ) which have chemical relationships , in silico methods employing structure from Protein Data Bank (PDB code: 1WLP). six...
Valproic acid (VPA) is a drug that has various therapeutic applications; however, it been associated with liver damage. Furthermore, interesting to propose new compounds derived from VPA as N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA). The HO-AAVPA better antiproliferative activity than the in different cancer cell lines. purpose of this study was evaluate injury by acute treatment (once administration) and repeated doses for 7 days under intraperitoneal administration. median lethal...
11‐beta‐hydroxysteroid dehydrogenase 1 (11‐βHED1) plays an important role in obesity and metabolic syndrome, due to it regulates cortisol levels. High levels produce gain of adipose tissue, release proinflammatory substances, free radicals (FR) 1,2 . Then the inhibition 11‐βHED1 by thiazole derivatives has been reported. However, nowadays there are not a drug inhibit enzyme. For instance, inhibitors developed Amgen/Biovitrum have yet approved is concluded, because, their clinical trials was...
It is know that compounds with phenol and thiol moieties have antioxidant activity. Therefore, the aim of this study was to synthetized three containing groups ((cysteine‐phenol (1), benzothiazole‐phenol (2) (3)) test then as agents. The activity evaluation carried out by DPPH determination inactivation •OH radical generated during Fenton reaction. results show reduction concetration dependent, (1) higher reducing power (>90%) 0.102 μM, in comparision N‐acetylcysteine (NAC) which 55%....