A5019754752- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Cancer Research and Treatments
- Colorectal Cancer Treatments and Studies
- Liver Disease Diagnosis and Treatment
- Uterine Myomas and Treatments
- Immune Cell Function and Interaction
- Esophageal and GI Pathology
- Anesthesia and Pain Management
- Endometriosis Research and Treatment
- Pain Management and Opioid Use
- Immunotherapy and Immune Responses
- Central Venous Catheters and Hemodialysis
- Liver Disease and Transplantation
- Venous Thromboembolism Diagnosis and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Anesthesia and Sedative Agents
- PARP inhibition in cancer therapy
- Cell death mechanisms and regulation
- Gallbladder and Bile Duct Disorders
- Maternal and fetal healthcare
McGill University Health Centre
2015-2025
McGill University
2013-2024
Auckland City Hospital
2021
Montreal General Hospital
2021
Royal Victoria Hospital
2013-2018
Royal Victoria Regional Health Centre
2013-2014
University Health Network
2005-2013
University of Toronto
1997-2010
Princess Margaret Cancer Centre
2005
Ontario Institute for Cancer Research
2003-2005
T cell receptor recognition of antigen can lead either to lymphocyte differentiation and proliferation or a state unresponsiveness, which is dependent on whether appropriate costimulatory signals are provided the mature cell. We have investigated novel intracellular signaling pathway by molecule CD28. CD28 engagement triggers activation an acidic sphingomyelinase (A-SMase), results in generation ceramide, important lipid messenger intermediate. A-SMase occurred resting as well activated...
Rapid activation of immune responses is necessary for antibacterial defense, but excessive can result in life-threatening septic shock. Understanding how these processes are balanced may provide novel therapeutic potential treating inflammatory disease. Fc receptors crucial innate activation. However, the role putative receptor IgM, known as Toso/Faim3, has to this point been unclear. In study, we generated Toso-deficient mice and used them uncover a critical regulatory function Toso...
The p53 tumor suppressor promotes cell cycle arrest or apoptosis in response to diverse stress stimuli. p53-mediated death depends large part on transcriptional up-regulation of target genes. One these targets, P53-induced protein with a domain (PIDD), was shown function as mediator p53-dependent apoptosis. Here we show that PIDD is cytoplasmic protein, and PIDD-induced growth suppression embryonic fibroblasts depend the adaptor receptor-interacting (RIP)-associated ICH-1/CED-3 homologous...
Treatment strategies for colorectal cancer liver metastasis (CRCLM) such as major hepatectomy and portal vein embolization (PVE) rely on regeneration. We aim to investigate the effect of neoadjuvant chemotherapy regeneration occurring after PVE hepatectomy.CRCLM patients undergoing or resection were identified retrospectively from our database. Liver data (expressed future remnant [FLR] percentage [%LR]), total volume (TLV) clinical characteristics collected.Between 2003 2013, 226 included...
Purpose To evaluate the effectiveness of superior hypogastric nerve block (SHNB) in reducing narcotic use after uterine artery embolization (UAE). Materials and Methods This study was a prospective, randomized, double-blind, parallel clinical trial patients referred to tertiary care university teaching hospital for UAE. Forty-four participants were enrolled (mean age, 46 years; range, 32-56 years). No consenting patient excluded. All randomized 1:1 undergo either sham procedure or SHNB....
Introduction The aim of this study is to determine if right arm peripherally inserted central catheters (PICCs) experienced fewer complications while controlling for gender, hand dominance, history malignancy, dwell time and catheter size. Methods This was an intention-to-treat randomized controlled trial conducted in academic medical center on two different sites between September 2012 2015. All patients older than 18 years or age without known previous line, contraindication the use a...
Purpose To evaluate the safety and efficacy of percutaneous transarterial embolization (PTAE) for treatment spontaneous soft-tissue hematomas (SSTHs) identify variables predictive short-term outcome. Materials Methods Between 2011 2017, outcome was retrospectively analyzed 112 patients (mean age ± standard deviation, 72 years 14; range, 28–92 years), including 65 women age, 73 12.7; 39–92 years) 47 men 70 14.9; 28–91 with SSTH treated PTAE. Thirty-day mortality, technical clinical success,...
In this pilot study, we assessed the safety and tolerability of combining sorafenib with 90Y radioembolization for treatment unresectable hepatocellular carcinoma (hcc).The conducted prospectively during 2009-2012, included eligible patients hcc a life expectancy at least 12 weeks. Each patient received (400 mg twice daily) 6-8 weeks before treatment. Safety were assessed.Of 40 enrolled, 29 completed (combined therapy). initial cohort, most common cause was hepatitis C (32.5%), staged Child...
Abstract Introduction We recently developed a double-balloon device, using widely available existing technology, to facilitate endoscopic ultrasound-guided gastroenterostomy (EUS-GE). Our aim is assess the feasibility of this modified approach EUS-guided double-balloon-occluded bypass (M-EPASS). Methods This was single-center retrospective study consecutive patients undergoing M-EPASS from January 2019 August 2020. The device consists two vascular balloons that optimize distension targeted...
Background: Resection of metastases is the only potential cure for patients with liver metastasis from colorectal cancer (CRC-LM). But despite an improved overall 5-year survival, recurrence rate still as high 60%. Non-alcoholic fatty disease (NAFLD) can decrease liver’s capacity to regenerate after resection and might also affect recurrence, potentially by elevating transforming growth factor β, levels specific metalloproteinases, oxidative stress. The objective present work was determine...
Background Image-guided procedures for treatment of liver diseases can be painful and require heavy sedation the patient. Local-regional nerve blocks improve pain control reduce oversedation risks, but there are no documented liver-specific blocks. Purpose To develop a safe technically simple block. Materials Methods Between March 2017 October 2019, three cadavers were dissected to evaluate hepatic hilar anatomy. The nerves targeted with transhepatic placement needle adjacent main portal...
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