A5038085275- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Connexins and lens biology
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Visual perception and processing mechanisms
- Optical measurement and interference techniques
- Corneal Surgery and Treatments
- Retinal Development and Disorders
- Optical Coherence Tomography Applications
- Ergonomics and Musculoskeletal Disorders
- Retinal and Optic Conditions
- Spatial Cognition and Navigation
- Photoacoustic and Ultrasonic Imaging
- Colorectal Cancer Surgical Treatments
- Tribology and Lubrication Engineering
- Advanced Nanomaterials in Catalysis
- Muscle activation and electromyography studies
- Cardiomyopathy and Myosin Studies
- Inflammatory mediators and NSAID effects
- Neural dynamics and brain function
- Surface Roughness and Optical Measurements
The University of Texas at Arlington
2015-2025
Pfizer (United States)
2010-2018
Smith-Kettlewell Eye Research Institute
2018
Case Western Reserve University
2012
Research to Prevent Blindness
2012
Ohio Lions Eye Research Foundation
2012
La Jolla Alcohol Research
2009-2011
University of Ulster
2008
Scripps Clinic
2004
Weatherford College
2004
There are no treatments for reversing or halting cataract, a disease of the structural proteins in eye lens, that has associations with other age-related degenerative conditions such as Alzheimer's disease. The incidence cataract and associated is increasing average age population rises. Protein folding diseases difficult to assess vivo their changes assessed after extraction. Nanotechnology can be used investigate protein intact lens well potential means drug delivery. Nanoparticles, cerium...
Varying amounts of saline and contrast material were injected into the pleural space cadavers to determine minimum amount fluid detectable on lateral decubitus radiographs. As increased, a predictable stepladder increase in density was observed; however, as little 5 ml visible properly exposed
To evaluate the safety and efficacy of three doses PF-04523655, a 19-nucleotide methylated double stranded siRNA targeting RTP801 gene, for treatment diabetic macular edema (DME) compared to focal/grid laser photocoagulation.This multicenter, prospective, masked, randomized, active-controlled, phase 2 interventional clinical trial enrolled 184 DME patients with best corrected visual acuity (BCVA) 20/40 20/320 inclusive in study eye. Patients were randomly assigned 0.4-mg, 1-mg, 3-mg...
To measure corneal and scleral radii of curvature in response to intraocular pressure (IOP).Using digital photographic profile images 16 fresh porcine eyes, the curvatures cornea sclera were determined five consecutive incremental 100 mul saline intravitreal injections. IOP was measured ocular rigidity calculated. Elastic moduli estimated.Intraocular radius increased linearly with increasing volume. There no statistical change curvature. The elasticity constant during 15-50 mm Hg increase...
The mechanisms causing the steady-state force enhancement following active skeletal muscle stretching are not well understood. Recently, we found direct evidence that part of is associated with engagement a passive component. In this study, reproduced conditions give consistent and evaluated mechanical properties so as to gain insight into its source. three primary results were (1). long lasting (>25 s), (2). was reduced in dose-dependent manner by amount shortening preceding stretching,...
Purpose: To evaluate the safety of escalating doses taprenepag isopropyl (PF-04217329), a selective EP2 receptor agonist administered as topical ophthalmic solution, versus its vehicle (Stage I), and dose-response alone in unfixed combination with latanoprost solution 0.005% II).Subjects Methods: Randomized, vehicle- active-controlled, double-masked, two-stage, dose-finding trial primary open-angle glaucoma (POAG) or ocular hypertension; first study patients (NCT00572455). Study eye: 26 mmHg...
Age-related Macular Degeneration (AMD) is the leading cause of visual impairment and blindness in elderly developed countries. Neovascular/exudative (wet) AMD aggressive form can involve choroidal neovascularization vascular leakage. Anti-vascular endothelial growth factor (anti-VEGF) medications have significantly improved treatment wet-AMD. However, only approximately 40% patients obtain full benefit from anti-VEGF therapy are given by intravitreal injection. Axitinib, a small molecule...
The magnitude of zonular forces required to change the shape human lens while focusing at near; i.e., accommodating, is still under investigation. During accommodation, ciliary muscle contraction induces a large increase in central optical power (COP). Here we used finite element (FE) analysis evaluate correlation between and surface curvatures, thickness, COP, overall longitudinal spherical aberration (LSA). Fresh isolated lenses from donors aged 20, 24, 26, 30 years were basis for...
The movement of the human lens equator during accommodation was examined in vivo. High-resolution ultrasound images were obtained from young subjects whose amplitude controlled with 1% tropicamide and 2% pilocarpine. To avoid errors that otherwise arise eye rotation or other movement, cornea sclera used as positional references comparative studies video unaccommodated accommodated states. During accommodation, at involved small displacement; i.e., < 100 microns, did not move anteriorly...
<h3>Aim</h3> To determine the viscoelastic properties of fresh human lenses obtained from cadavers under 40 years age. <h3>Methods</h3> 52 intact clear, were 26 donors (mean age 27.5±9.2 years) within 9±4 h death. The lens nuclei and 16 cortices quantified 42±10 death using a controlled-strain, linear, simple-shear rheometer. <h3>Results</h3> means (±SD) at frequency 75 Hz were: elastic shear modulus, G′=11.00±4.67 Pa, viscous G′′=24.91±10.98 magnitude complex |G*|=27.23 dynamic viscosity,...
The purpose of the study was to demonstrate and evaluate use digital-image photography measure central thickness equatorial diameter whole fresh human crystalline lenses free all zonular attachments. Forty-one donor postmortem intact clear lenses, with a mean age 28.5 +/- 16.4 years, were obtained by contributing eye banks. removed bank shipped in Optisol-GS, physiologic preservative storage medium, at 7 degrees C. stored same temperature throughout this study. This medium has been...
The illusion generated by a "pincushion grid" is not predicted from the two-dimensional Fourier transform of grid. This implies that visual system may perform transforms observed patterns.
Abstract How the human eye focuses for near; i.e. accommodates, is still being evaluated after more than 165 years. The mechanism of accommodation essential understanding etiology and potential treatments myopia, glaucoma presbyopia. Presbyopia affects 100% population in fifth decade life. lens encased a semi-elastic capsule with attached ligaments called zonules that mediate ciliary muscle forces to alter shape. are at equator. fundamental issue whether during all relax causing central...