A5100699787- Food composition and properties
- Plant Micronutrient Interactions and Effects
- Phytase and its Applications
- Antioxidant Activity and Oxidative Stress
- Plant Genetic and Mutation Studies
- Plant biochemistry and biosynthesis
- Wheat and Barley Genetics and Pathology
- Redox biology and oxidative stress
- Selenium in Biological Systems
- Cancer Immunotherapy and Biomarkers
- IgG4-Related and Inflammatory Diseases
- Cancer Cells and Metastasis
- Microbial Metabolites in Food Biotechnology
- Plant tissue culture and regeneration
- Advanced Proteomics Techniques and Applications
- Ferroptosis and cancer prognosis
- Coenzyme Q10 studies and effects
- Plant Disease Resistance and Genetics
- Neuroendocrine Tumor Research Advances
- Plant nutrient uptake and metabolism
- Gastrointestinal Tumor Research and Treatment
- Peptidase Inhibition and Analysis
- Lipoproteins and Cardiovascular Health
- Enzyme Structure and Function
- ATP Synthase and ATPases Research
Jiaxing University
2022
Zhejiang Provincial People's Hospital
2015-2020
Hangzhou Medical College
2019-2020
University of California, Davis
2012-2017
Starch is the largest component of wheat (Triticum aestivum L.) grain and consists approximately 70-80% amylopectin 20-30% amylose. Amylopectin a highly-branched, readily digested polysaccharide, whereas amylose has few branches forms complexes that resist digestion mimic dietary fiber (resistant starch). Down-regulation starch branching enzyme II (SBEII) gene by RNA interference (RNAi) was previously shown to increase content in both hexaploid tetraploid wheat. We generated ethyl methane...
Increases in the proportion of amylose starch wheat grains result higher levels resistant starch, a fermentable dietary fiber associated with human health benefits. The objective this study was to assess effect combined mutations five STARCH BRANCHING ENZYME II ( SBEII ) genes on composition, grain yield and bread-making quality two hexaploid varieties. Significantly (∼60%) content (10-fold) detected mutants than wild-type controls. Mutant lines showed significant decrease total (6%), kernel...
Increased amylose in wheat (Triticum ssp.) starch is associated with increased resistant starch, a fermentable dietary fiber. Fermentation of the large intestine produces short-chain fatty acids that are human health benefits. Since foods an important component diet, increases and grains have potential to deliver benefits number people. In three replicated field trials we found mutations branching enzyme II genes (SBEIIa SBEIIb) both A B genomes (SBEIIa/b-AB) durum [T. turgidum L. subsp....
Starch present in the endosperm of common wheat ( Triticum aestivum L.) grains is an important source carbohydrates worldwide. Starches with a greater proportion amylose have increased levels resistant starch, dietary fiber that can provide human health benefits. Induced mutations STARCH BRANCHING ENZYME II SBEII ) genes are associated and starch. Ethyl methane sulfonate SBEIIa SBEIIb paralogs were combined hexaploid cultivar Lassik. Four mutant combinations generated: SBEIIa/b ‐AB (Reg. No....
Durum wheat [Triticum turgidum L. subsp. durum (Desf.) Husn.], used in pasta, couscous, and flatbread production, is an important source of starch food products worldwide. The amylose portion the forms resistant complexes that resist digestion contribute to dietary fiber. Increasing amount by mutating STARCH BRANCHING ENZYME II (SBEII) genes has potential provide human health benefits. Ethyl methane sulfonate mutations linked SBEIIa SBEIIb paralogs were combined on chromosomes 2A...
The proliferation of vascular smooth muscle cells (VSMCs) is one the main features atherosclerosis induced by high glucose. Mevalonate pathway an important metabolic that plays a key role in multiple cellular processes. aim this study was to define whether enzyme expression mevalonate changed proliferated VSMCs during atherogenic process diabetic mice. Diabetes BALB/c mice with streptozotocin (STZ, 50 mg/kg/day for 5 days). Induction diabetes STZ associated increase lesion area and media...
Objective Increasing evidence has indicated an association between immune cells infiltration in LSCC and clinical outcome. The aim of this research was tantamount to comprehensively investigate the effect 22 tumor infiltrating (TIICs) on prognosis patients. Methods In our research, CIBERSORT algorithm utilized calculate proportion TIICs 502 cases from TCGA cohort. Cases with a P -value <0.05 were kept for further study. Using algorithm, we first investigated difference normal tissue...
Chronic obstructive pulmonary disease (COPD) is a common airway disease, and epithelial mesenchymal transition (EMT) participated in the pathogenesis of COPD. However, role CD147 COPD remains largely unknown. In order to clarify EMT induced by cigarette smoke, we established animal cell model mean smoke exposure detected expressions markers via PCR, WB IF. RNA inference was applied study CSE vitro. NAC H2O2 were used oxidative stress signaling pathway this model. As result, upregulated...
The proliferation of vascular smooth muscle cells (VSMCs) is one the main features atherosclerosis accelerated by hyperglycemia. Our previous studies found that farnesyl pyrophosphate synthase (FPPS, EC 2.5.1.10), an essential enzyme in mevalonate pathway, was upregulated aorta media from diabetic mice along with process atherosclerosis. However, exact role FPPS high glucose‑induced VSMCs largely unclear. In our study, we alendronate (an inhibitor) attenuated vivo and suppressed vitro....
The proliferation of vascular smooth muscle cells (VSMCs) induced by oxidative injury is one the main features in diabetes-accelerated atherosclerosis. Geranylgeranyl transferase-I (GGTase-I) an essential enzyme mediating posttranslational modification, especially geranylgeranylation small GTPase, Rac1. Our previous studies found that GGTase-I played important role However, its exact largely unclear. In this study, mouse conditional knockout VSMC (Pggt1b Δ/Δ mice) was generated using...