A5100630479- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Chronic Lymphocytic Leukemia Research
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Chronic Myeloid Leukemia Treatments
- Pregnancy and preeclampsia studies
- Lung Cancer Treatments and Mutations
- Drug Transport and Resistance Mechanisms
- RNA Interference and Gene Delivery
- Viral gastroenteritis research and epidemiology
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- CAR-T cell therapy research
- Reproductive System and Pregnancy
- Silkworms and Sericulture Research
- Advanced biosensing and bioanalysis techniques
- Cancer Cells and Metastasis
- Clostridium difficile and Clostridium perfringens research
- Cancer Genomics and Diagnostics
- Animal Virus Infections Studies
Binzhou University
2015-2024
Binzhou Medical University
2015-2024
Qingdao Eighth People's Hospital
2021
First People’s Hospital of Jingmen
2017
Nanjing Normal University Taizhou College
2015
Nanjing Normal University
2012-2015
Nanjing University
2014
Nanjing Agricultural University
2009
MicroRNAs (miRNAs) are endogenous non-coding genes that participate in post-transcription regulation by either degrading mRNA or blocking its translation. It is considered to be very important regulating insect development and metamorphosis. We conducted a large-scale screening for miRNA the silkworm Bombyx mori using sequence-by-synthesis (SBS) deep sequencing of mixed RNAs from egg, larval, pupal, adult stages. Of 2,227,930 SBS tags, 1,144,485 ranged 17 25 nt, corresponding 256,604 unique...
Mesenchymal stem cells (MSCs) at maternal-fetal interface are considered to play an important role in the pathogenesis of pre-eclampsia (PE). microRNAs (miRNAs) also have influence on differentiation, maturation, and functions MSCs. Our aim this study was determine differential expression miRNAs decidua-derived MSCs (dMSCs) from severe PE normal pregnancies. miRNA profiles dMSCs five patients with healthy pregnant women were screened using microarray. Then, bioinformatic analysis microarray...
Circulating microRNAs (miRNAs) are important in the diagnosis of a number diseases, since serum or plasma miRNAs more stable compared with miRNA isolated from blood samples. The aim present study was to investigate association between expression levels let‑7c and clinical breast cancer (BC). circulating 90 BC patients 64 healthy controls were determined by performing reverse transcription‑quantitative polymerase chain reaction assay. results demonstrated that downregulated tissues...
BACKGROUND:Clinical monitoring of EGFR-positive NSCLC patients is important to gauge treatment response. The current study addresses the usage circulating tumor DNA (ctDNA) as a prognostic marker during first-generation TKIs. MATERIAL AND METHODS:Serial samplings peripheral blood from 200 were taken. Baseline ctDNA quantification was conducted by digital droplet PCR before TKI administered and compared primary biopsies. Thereafter sampling at different cycles measured assessed for its...
Chronic myeloid leukemia (CML) is a malignant hematological disease, and drug resistance often related to poor prognosis. MicroRNAs (miRNA) play pivotal role in transcriptional regulation, cell development, chemotherapy resistance. Here, we describe the effect of let-7b on resistant cells examine relevance as biomarker for adriamycin Results showed that was downregulated K562/ADM (KA) cells, downregulation K562 KA increased ADM The inhibition subsequently induced upregulation AURKB. Finally,...
MicroRNAs (miRs) participate in the development of several cancers. miR‑361‑5p suppresses proliferation hepatocellular carcinoma (HCC) cells. However, its function and potential underlying mechanism action chemoresistance HCC remains unknown. Therefore, cisplatin (DDP)‑resistant cells were used to study role resistance chemotherapy. TargetScan software dual‑luciferase reporter assays determine whether MAPK kinase 9 (MAP3K9) is a target gene miR‑361‑5p. Subsequently, reverse...
Chronic myeloid leukemia (CML) is a hematological disease, and imatinib (IM) resistance represents major problem for its clinical treatment. In the present study, role of tribbles pseudokinase 2 (TRIB2) in IM CML possible mechanism were investigated. It was found that TRIB2 highly expressed IM‑resistant patients with through Oncomine database this conclusion confirmed using reverse transcription‑quantitative PCR western blot experiments. Knockdown to increase drug sensitivity KG cells...