A5004066168- Thyroid Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Thyroid Cancer Diagnosis and Treatment
- Birth, Development, and Health
- Neuroscience and Neuropharmacology Research
- Pituitary Gland Disorders and Treatments
- Neuroendocrine regulation and behavior
- Cognitive Functions and Memory
- Memory and Neural Mechanisms
- Autism Spectrum Disorder Research
- Estrogen and related hormone effects
- Sleep and Wakefulness Research
- Child Development and Digital Technology
- Pregnancy and preeclampsia studies
- RNA Research and Splicing
- Down syndrome and intellectual disability research
- Cytokine Signaling Pathways and Interactions
- Ion channel regulation and function
University of Chicago
2022-2025
University of Illinois Chicago
2024
University of Chicago Medical Center
2024
Universidade Presbiteriana Mackenzie
2016-2023
Abstract The Thr92Ala-Dio2 polymorphism is prevalent worldwide, with about 50% of the population carrying at least one allele. Ala92-Dio2 allele encodes a less active D2 enzyme and has been associated neurodegenerative diseases, hypertension, insulin resistance. To understand why its phenotypic effects are variable across different populations, in this study, we examined impact genetic background on polymorphism. We focused thyroid gland two genetically distant mouse strains, C57BL/6J (B6)...
L-thyroxine (L-T4) monotherapy is the standard treatment for hypothyroidism, administered daily to normalize TSH levels. Once absorbed, T4 converted T3 alleviate most symptoms. However, this abnormally elevates plasma levels in over 50% of patients. Using L-T4-treated Thyroid Hormone (TH) Action Indicator mice, which express a T3-regulated luciferase (Luc) reporter, we examined whether these elevations disrupt TH signaling. Hypothyroid mice exhibited reduced Luc expression across brain...
Norepinephrine plays an important role in modulating memory through its beta-adrenergic receptors (Adrβ: β1, β2 and β3). Here, we hypothesized that multisensory stimulation would reverse impairment caused by the inactivation of Adrβ3 (Adrβ3KO) with consequent inhibition sustained glial-mediated inflammation. To test this, 21- 86-day-old Adrβ3KO mice were exposed to 8-week (MS) protocol comprised gustatory olfactory stimuli positive negative valence; intellectual challenges reach food; use...
Abstract About half of the world population carries at least one allele Ala92-DIO2, which slows down activity type 2 deiodinase (D2), enzyme that activates T4 to T3. Carrying Ala92-DIO2 has been associated with increased body mass index and insulin resistance, but this not reproduced in all populations. To test if genetic background affects impact polymorphism, here we studied genetically distant C57Bl/6J (B6) FVB/N (FVB) mice carrying Ala92-Dio2 as compared control Thr92-Dio2 allele....
Abstract The regulation of thyroid activity and hormone (TH) secretion is based on feedback mechanisms that involve the anterior pituitary TSH medial basal hypothalamus TSH-releasing hormone. Plasma T3 levels can be “sensed” directly by hypothalamus; plasma T4 require local conversion to T3, which mediated type 2 deiodinase (D2). To study D2-mediated production in gland, we used mouse explants incubated with 125I-T4 for 48 hours measure at different concentrations free T4. results were...
Norepinephrine plays an important role in modulating memory consolidation and evocation through its beta-adrenergic receptors (Adrβ: β1, β2 β3), which are expressed the hippocampus (HC) amygdala (AMY). Here we hypothesized that multisensory stimulation would reverse impairment caused by inactivation of Adrβ3 with consequent inhibition sustained glial-mediated inflammation glutamatergic depuration. To test this, 21- 86-day-old Adrβ3KO mice...
Abstract Gestational hypothyroidism can impair development, cognition, and mood. Here, we tested whether multisensory stimulation (MS) improves the phenotype of rats born to surgically thyroidectomized (Tx) dams suboptimally treated with LT4. 8-week-old female Tx Wistar were kept on daily LT4 (0.7 µg/100 g body weight) dosed by gavage (serum TSH T4 levels indicated moderate hypothyroidism) 3 weeks later placed for breeding. MS litter started at age 60 days lasted 8 weeks. It consisted twice...
The Thr92Ala-Dio2 polymorphism has been associated with reduced cognition in 2-month-old male mice and increased risk for cognitive impairment Alzheimer’s disease African Americans. This attributed to thyroid hormone (TH) signaling endoplasmic reticulum (ER) stress the brain. Here we studied mouse model saw that older (7–8-month-old) exhibited a more severe impairment, which extended different aspects of declarative working memories. A similar phenotype was observed 4–5-month-old female...
Abstract Disclosure: A. Batistuzzo: None. B. Bocco: E. McAninch: M.O. Ribeiro: A.C. Bianco: Consulting Fee; Self; Abbvie. Fvb/Ant Mice Carrying the Thr92Ala-Dio2 Polymorphism Have a Goiter Introduction: The Thr92Ala-DIO2 polymorphism is prevalent worldwide, with about 50% of population carrying at least one polymorphic allele. Ala-D2 ectopically located in Golgi apparatus and causes endoplasmic reticulum (ER) stress. It also 40 % less active than Thr92-D2, thus T3 production could be...
ABSTRACT Norepinephrine plays an important role in modulating the processes of memory consolidation and evocation through its beta-adrenergic receptors (Adrβ), which are expressed hippocampus amygdala. Several studies have shown that all three subtypes Adrβ (β 1 , β 2 3 ) play cognition. Environmental enrichment (EE), a technique initially used to decrease stress animals held captive environments, has also been produce cognitive benefits both healthy sick animals. In this study, we...