A5019018177- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Microbial Metabolic Engineering and Bioproduction
- Virus-based gene therapy research
- Hepatitis B Virus Studies
- Ocular Infections and Treatments
- Fisheries and Aquaculture Studies
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Transgenic Plants and Applications
- Child and Adolescent Psychosocial and Emotional Development
- COVID-19 and Mental Health
- CRISPR and Genetic Engineering
- Ocular Surface and Contact Lens
- Sentiment Analysis and Opinion Mining
- Essential Oils and Antimicrobial Activity
- ATP Synthase and ATPases Research
- Traffic Prediction and Management Techniques
- Mental Health via Writing
- Plant Parasitism and Resistance
- E-commerce and Technology Innovations
- Health disparities and outcomes
- Leaf Properties and Growth Measurement
- Blockchain Technology Applications and Security
- Sustainable Industrial Ecology
University of Massachusetts Chan Medical School
2023-2025
Indira Gandhi Delhi Technical University for Women
2023
CanKids KidsCan
2020-2022
Indian Institute of Technology Delhi
1982-2022
Chandigarh University
2022
Narsee Monjee Institute of Management Studies
2019
Karlsruhe Institute of Technology
2018
University of Kota
2018
Central Salt and Marine Chemicals Research Institute
2013
Conformational dynamics of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein (S) mediate exposure binding site for cellular receptor, angiotensin-converting enzyme (ACE2). The N-terminal domain (NTD) S binds terminal sialic acid (SA) moieties on cell surface, but functional role this interaction in virus entry is unknown. Here, we report that NTD-SA enhances both S-mediated attachment and ACE2 binding. Through single-molecule Förster resonance energy...
Membrane-active peptides can be classified as cell-penetrating and antimicrobial (AMPs) that are known to play interchangeable roles. In this study, dual behaviour was studied for the marine AMP, tachyplesin. It is a well-established cyclic peptide possess properties investigated its property cargo delivery ability. Because of derivation from organism well nature, it has been shown higher stability in vitro. internalization established characterized both plant mammalian systems. deliver...
During the 2013-2016 Ebola virus (EBOV) epidemic in Western Africa, an A82V mutation emerged envelope glycoprotein (GP) that persisted most circulating isolates. Previous studies demonstrated increased GP-mediated membrane fusion and altered its dependence on host factors. The mechanistic basis for these observations, particular impact of conformational changes GP are needed fusion, has not been evaluated molecular detail. Here, using dynamics simulations, fluorescence correlation...
Abstract Claudin 6 (CLDN6) is a tight junction protein that highly expressed in various human cancers, including ovarian and endometrial while it not found normal adult tissues. 9 (CLDN9), which shares significant homology with CLDN6, displays similar expression patterns, being nearly absent tissues but upregulated cancers. We propose to target both CLDN6 CLDN9 simultaneously enhance anti-tumor efficacy broaden treatment options for more patients. successfully discovered an antibody binds...
Interaction between the Ebola virus envelope glycoprotein (GP) and endosomal membrane is an essential step during entry into cell. Acidic pH Ca2+ have been implicated in mediating GP-membrane interaction. However, molecular mechanism by which these environmental factors regulate conformational changes that enable engagement of GP with target unknown. Here, we apply fluorescence correlation spectroscopy (FCS) single-molecule Förster resonance energy transfer (smFRET) imaging to elucidate how...
The emerging field of synthetic biology holds tremendous potential for developing novel drugs to treat various human conditions. current study discusses the scope therapeutics via microbial approach. In this context, aims at designing, engineering and building new cells that do not pre-exist in nature as well re-engineer existing microbes synthesis therapeutic products. It is expected construction genetic circuitry will greatly benefit from data generated by 'omics' approaches...
We have examined the reactivation mechanism of tabun-conjugated AChE with various drugs using density functional theory (DFT) and post-Hartree-Fock methods. The electronic environments structural features neutral oximes (deazapralidoxime 3-hydroxy-2-pyridinealdoxime) charged monopyridinium oxime (2-PAM) bispyridinium (Ortho-7) are different, hence their efficacy varies towards process AChE. calculated potential energy surfaces suggest that a reactivator is less favorable for tabun-inhibited...
In this paper, we address the growing concern of traffic violations in India caused by increasing number vehicles on road and rising accidents fatalities. To tackle issue, suggest use social media platforms, particularly Twitter, as a potential tool for identifying analyzing violations. Our approach involves leveraging data available official Twitter handles police departments to develop dataset tweets related incidents four Indian metropolitan cities - Delhi, Mumbai, Kolkata Chennai. The...
Active management of the third stage labor (AMTSL) is a critical intervention for prevention postpartum hemorrhage (PPH), which still most common cause maternal morbidity and mortality worldwide. The objective study to compare effect intramuscular methylergometrine, rectal misoprostol, low-dose intravenous oxytocin in AMTSL terms amount blood loss duration labor, cost-effectiveness, side profile.
ABSTRACT During the 2013-2016 Ebola virus epidemic in Western Africa, an A82V mutation emerged envelope glycoprotein (GP) that persisted most circulating isolates. Previous studies demonstrated increased GP-mediated membrane fusion and altered its dependence on host factors. The mechanistic basis for these observations, particular impact of conformational changes GP are needed fusion, has not been evaluated molecular detail. Here, using a combination dynamics simulations, fluorescence...
The aim of the study was to “Quality sleep during Corona virus (COVID-19) outbreak”. conducted lockdown in India, and a sample 136 collected through snowball sampling with help social platforms. Sleep Condition Indicator (Espie, 2014) used collect data along demographic details. It concluded that there existed no significant difference quality males females (t=1.83; p= 0.069; p>0.05), however people aged between 18-24 years 25- 32 (t=-2.19; p=0.038; p<0.05) , unmarried married...