A5085372152- Calpain Protease Function and Regulation
- Autophagy in Disease and Therapy
- Nerve injury and regeneration
- Aldose Reductase and Taurine
- Endoplasmic Reticulum Stress and Disease
Shenyang Pharmaceutical University
2017-2018
Age-related macular degeneration (AMD) is a complex disease with multiple initiators and pathways that converge on death for retinal pigment epithelial (RPE) cells. In this study, effects of taurine calpains, autophagy, endoplasmic reticulum (ER) stress, apoptosis in ARPE-19 cells (a human RPE cell line) were investigated. We first confirmed ER stress induced by Earle’s balanced salt solution (EBSS) through starvation to induce metabolic stress. Secondly, inhibition 4-phenyl butyric acid...
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are key transmembrane proteins leading to reactive oxygen species (ROS) overproduction. However, the detailed roles of NOXs in retinal pigment epithelial (RPE) cell metabolic stress induced by Earle's balanced salt solution (EBSS) through starvation remain unclear. In this study, we investigated what play regard calpain activity, endoplasmic (ER), autophagy, and apoptosis during ARPE-19 cells. We first found that EBSS an...