A5019486364- Transplantation: Methods and Outcomes
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Renal Transplantation Outcomes and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Organ Transplantation Techniques and Outcomes
- Cytomegalovirus and herpesvirus research
- Mechanical Circulatory Support Devices
- Polyomavirus and related diseases
- Viral Infections and Immunology Research
- Herpesvirus Infections and Treatments
- Organ and Tissue Transplantation Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- SARS-CoV-2 and COVID-19 Research
- Toxoplasma gondii Research Studies
- Antifungal resistance and susceptibility
- Tissue Engineering and Regenerative Medicine
- Fungal Infections and Studies
- Immune cells in cancer
- Cell death mechanisms and regulation
- Wireless Power Transfer Systems
- Atrial Fibrillation Management and Outcomes
- Nosocomial Infections in ICU
Baylor University Medical Center
2019-2025
Texas A&M University
2025
University of Colorado Anschutz Medical Campus
2004-2019
University of Colorado Denver
2009-2019
University of Colorado Health
2003-2015
National Jewish Health
2009-2010
The Medical Center of Aurora
2009
Diabetes Australia
2009
Pulmonary and Critical Care Associates
2006
Boston University
2002
Obesity and weight gain are characterized by increased adipose tissue mass due to an increase in the size of individual adipocytes generation new adipocytes. New believed arise from resident preadipocytes mesenchymal progenitor cells. However, it is possible that cells other tissues, particular BM, could also contribute development tissue. We tested this hypothesis transplanting whole BM GFP-expressing transgenic mice into wild-type C57BL/6 subjecting them a high-fat diet or treatment with...
Supplementation of cultured human pulmonary arterial endothelial cells (PAEC) with sn-1- O-hexadecylglycerol (HG) resulted in an approximately twofold increase cellular levels plasmalogens, a subclass phospholipids known to have antioxidant properties; this was due, primarily, fourfold the choline plasmalogens. Exposure unsupplemented PAEC hypoxia (Po 2 = 20–25 mmHg) caused reactive oxygen species (ROS) over period 5 days coincident decrease viability. In contrast, HG-supplemented survived...
Levi ME, Quan D, Ho JT, Kleinschmidt‐DeMasters BK, Tyler KL, Grazia TJ. Impact of rituximab‐associated B‐cell defects on West Nile virus meningoencephalitis in solid organ transplant recipients. Clin Transplant 2009 DOI: 10.1111/j.1399‐0012.2009.01044.x © John Wiley & Sons A/S. Abstract: Evidence suggests that (WNV) neuroinvasive disease occurs more frequently both and human stem cell The effect concomitant anti‐B‐cell therapy with rituximab, a CD20 + monoclonal antibody, WNV infection...
Evidence supports the use of 12 months cytomegalovirus prophylaxis in all at-risk lung transplants; whether serostatus can be used to further optimize this duration remains determined. The purpose retrospective study was determine if both donor and recipient were associated with late-onset cytomegalovirus. primary outcome proportion transplants that developed infection or disease during 180-day period following 6 each serotype. Two hundred forty-four consecutive evaluated, 131 included....
Background Pneumonia mortality can be decreased by early antibiotic administration. Pathogen identification aims to minimize inappropriate, nontargeted exposure. Molecular assays expedite organism through nucleic acid detection and antimicrobial resistance screening for genetic markers.
CD4 T cells can suffice as effector to mediate primary acute cardiac allograft rejection. Although readily kill appropriate target in vitro, the corresponding role of such cytolytic activity for mediating rejection vivo is unknown. Therefore, we determined whether molecules perforin (PFP) and/or FasL (CD95L) were necessary cell-mediated vivo.Wild-type C3H(H-2) or Fas (CD95)-deficient C3Hlpr (H-2) hearts transplanted into immune-deficient C57B6rag mice. Then, recipients reconstituted with...
CD4 T cells are both necessary and sufficient to mediate acute cardiac allograft rejection in mice. This process requires "direct" engagement of donor MHC class II molecules. That is, by CD4+ target expression the not host. However, it is unclear whether cell on hemopoietic cells, nonhemopoietic or both. To address this issue, bone marrow transplantation mice was used generate chimeric heart donors which expressed either somatic cells. We report that direct recognition individually rate...
It is now over forty years since this technique was first reported by Corry, Wynn and Russell. Although it took some for other labs to become proficient in utilize technique, widely used many laboratories around the world. A significant refinement original developed 2001 Niimi. Described here are techniques that have evolved more than a decade hands of three surgeons (Plenter, Grazia, Pietra) our center. These being passed on younger generation researchers. Based largely Niimi experience,...
In transplantation, a major obstacle for graft acceptance in MHC-matched individuals is the mismatch of minor histocompatibility Ags. Minor Ags are peptides derived from polymorphic proteins that can be presented by APCs on MHC molecules. The APC subtype uniquely responsible rejection Ag-mismatched grafts has not yet been identified. this study, we examined three mouse models: 1) male-specific Ags, 2) distinct and 3) skin transplant. This study demonstrates absence pathogen-associated...
Abstract Purpose of Review We explore the challenges managing solid organ transplant recipients (SOTRs) during COVID-19 pandemic, with a focus on prolonged viral detection in immunosuppressed individuals. Recent Findings SOTR guidelines recommend three mRNA vaccine doses additional booster dosing and continued protective post-vaccination measures. therapies are similar for SOTRs non-SOTRs, although drug-drug interactions limit use some such as nirmatrelvir/ritonavir (NIM-RTV). Inpatient...
Abstract Direct acting oral anticoagulants (DOACs) have become the mainstay of treatment for patients requiring anticoagulation atrial arrhythmias and venous thromboembolism (VTE) but safety efficacy has not been established in lung transplantation. This is a retrospective review 28 adult transplant who were prescribed apixaban stroke prevention or VTE between October 15, 2015 December 31, 2018. The primary outcome was composite measured by recurrence breakthrough bleeding events. Seven...
We present a case of 57-year-old man who underwent bilateral lung transplantation for idiopathic pulmonary fibrosis. His immediately post-operative course was complicated by fever and cardiac arrest. Despite supportive care broad-spectrum antibiotics, he experienced continued clinical decline. Autopsy results indicated angioinvasive mucormycosis coronary arteritis resulting in acute myocardial infarction as the cause death.
It is now over forty years since this technique was first reported by Corry, Wynn and Russell. Although it took some for other labs to become proficient in utilize technique, widely used many laboratories around the world. A significant refinement original developed 2001 Niimi. Described here are techniques that have evolved more than a decade hands of three surgeons (Plenter, Grazia, Pietra) our center. These being passed on younger generation researchers. Based largely Niimi experience,...