A5043714631- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Complementary and Alternative Medicine Studies
- Cancer Diagnosis and Treatment
- Acupuncture Treatment Research Studies
- DNA Repair Mechanisms
- Antioxidants, Aging, Portulaca oleracea
- Bladder and Urothelial Cancer Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Cell Adhesion Molecules Research
- Therapeutic Uses of Natural Elements
- Multiple and Secondary Primary Cancers
- Bone health and treatments
- Urologic and reproductive health conditions
- Genetic factors in colorectal cancer
- Nutritional Studies and Diet
- Sexual function and dysfunction studies
- Body Contouring and Surgery
- Cancer, Lipids, and Metabolism
- Ultrasound Imaging and Elastography
- Molecular Biology Techniques and Applications
- Global Cancer Incidence and Screening
- Pain Management and Placebo Effect
- Colorectal Cancer Screening and Detection
- Nutrition and Health in Aging
Martini-Klinik
2016-2025
Universität Hamburg
2016-2025
University Medical Center Hamburg-Eppendorf
2016-2025
Metropolitan University
2024
Eppendorf (Germany)
2019
The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and unique research platform network to obtain substantial knowledge about several important risk prognostic factors in major chronic diseases. A random sample of 45,000 participants between 45 74 years age from the general population Hamburg, Germany, are taking part an extensive baseline assessment at one dedicated center. Participants undergo 13 validated 5 novel examinations primarily...
Biglycan (BGN), a proteoglycan of the extracellular matrix, is included in mRNA signatures for prostate cancer aggressiveness. To understand impact BGN on prognosis and its relationship to molecularly defined subsets, we analyzed expression by immunohistochemistry tissue microarray containing 12,427 cancers. Seventy-eight percent 11,050 interpretable cancers showed expression, which was considered as low intensity 47.7% high 31.1% protein rose with increasing pathological tumor stage,...
To evaluate the advantages of adding acupuncture to standard postoperative pain management for open radical prostatectomy (RP). A randomized controlled trial (1:1:1) comparing routine analgesic care (control [CON]) vs addition press tack needle (ACU) or placebo acupressure (SHAM) after RP was performed. total 126 patients were enrolled between February 2020 and April 2021. After RP, CON group received analgesia, ACU long-term with tacks at specific points (P-6, Shenmen SP-6) along SHAM same...
No AccessJournal of UrologyAdult Urology1 Feb 2015Use Phosphodiesterase Type 5 Inhibitors May Adversely Impact Biochemical Recurrence after Radical Prostatectomy Uwe Michl, Frederike Molfenter, Markus Graefen, Pierre Tennstedt, Sascha Ahyai, Burkhard Beyer, Lars Budäus, Alexander Haese, Hans Heinzer, Su Jung Oh, Georg Salomon, Thorsten Schlomm, Thomas Steuber, Imke Thederan, Hartwig Huland, and Derya Tilki MichlUwe Michl Martini-Clinic Prostate Cancer Center, University Hospital...
Animal model experiments have suggested a role of the DNA repair protein ERCC1 (Excision Repair Cross-Complementation Group 1) in prostate cancer progression. To better understand impact expression human cancer, preexisting tissue microarray (TMA) containing more than 12,000 specimens was analyzed by immunohistochemistry and data were compared with tumor phenotype, PSA recurrence several most common genomic alterations (TMPRSS2:ERG fusions: deletions PTEN, 6q, 5q, 3p). staining seen 64.7%...
Abstract Y-box binding protein 1 (YB-1) is an RNA and DNA factor with potential prognostic cancer. To evaluate the clinical impact of YB-1, a tissue microarray 11,152 prostate cancers was analysed by immunohistochemistry. Cytoplasmic nuclear staining separately analysed. YB-1 absent or weak in normal epithelium but seen 86,3% carcinomas. weak, moderate, strong 29.6%, 43.7% 13.0% tumours accompanied 32.1% cases. Particularly strongly linked to poor patient prognosis (p < 0.0001). more...
γ-glutamyl-hydrolase (GGH) is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. Employing GGH immunohistochemistry on tissue microarray with 12,427 prostate cancers, we found expression was negative to low in normal epithelium, whereas 88.3% of our 10,562 interpretable cancers showed expression. staining considered as intensity 49.6% high 38.6% cancers. High linked the TMPRSS2:ERG-fusion positive subset (p <...
Polymorphisms of the base excision repair gene APE1 may be associated with an increased risk for developing prostate cancer. In other cancer types, altered protein expression is a candidate prognostic marker. Using immunohistochemistry, we thus analyzed in 9763 cancers tissue microarray (TMA) attached clinical and molecular data. The comparison normal revealed upregulation samples. immunostaining was considered weak 20.2%, moderate 36.7%, strong 33.4% cancers. Strong markedly more frequent...
The A Disintegrin and Metalloproteinase (ADAM) family of endopeptidases plays a role in many solid cancers includes promising targets for anticancer therapies. Deregulation ADAM15 has been linked to tumor aggressiveness cell line studies suggest that overexpression may also be implicated prostate cancer. To evaluate the impact expression its relationship with key genomic alterations, tissue microarray containing 12,427 was analyzed by immunohistochemistry. compared phenotype, prognosis...
In order to restrain the uncontrolled spread of 2019 coronavirus, COVID-19, and provide sufficient intensive care unit (ICU) capacity, medical specializations needed develop new routines risk strategy protocols. Those restrictions have also impacted urological community. Several organizations developed specific information hubs, blogs resource centres focused on how tackle COVID-19 situation [1-3]. Although German Society Urology (Deutsche Gesellschaft für Urologie) published a...
Abstract Background Prostate cancer (PCa) is the most frequently diagnosed malignant tumor in men. The potential benefit of a healthy lifestyle contrasts sharply with observed poor adherence to current international guidelines. Thus, well‐designed sustainable interventions aftercare that can be translated into routine practice are highly recommended. present pilot study aimed evaluate feasibility and acceptability multimodal intervention program PCa patients after radical prostatectomy (RP)....
Prostate cancer (PCa) detection is usually achieved by PSA measurement and, if indicated, further diagnostics. The recent EAU guidelines recommend a first test at the age of 50 years, no family history PCa or BRCA2 mutation exists. However, some men might harbor significant younger age; thus we evaluated histopathological results treated with radical prostatectomy (RP) in their 40 s our institution.We relied on data all patients who underwent RP institution between 1992 and 2020 were than...
Effects of a Protein Optimized Diet Combined with Moderate Resistance Training on the Postoperative Course in Older Patients Hip Fracture