A5092921431- Angiogenesis and VEGF in Cancer
- Coronary Interventions and Diagnostics
- Cardiomyopathy and Myosin Studies
- Connective tissue disorders research
- Cardiovascular Health and Disease Prevention
- Cell Adhesion Molecules Research
- Bone and Dental Protein Studies
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Force Microscopy Techniques and Applications
- Cellular Mechanics and Interactions
Michigan Technological University
2023-2024
Michigan United
2024
Abstract The stiffness of the extracellular matrix induces differential tension within integrin-based adhesions, triggering mechanoresponses. However, it has been unclear if stiffness-dependent is induced solely by myosin activity. Here, we report that in absence contractility, 3T3 fibroblasts still transmit levels traction. This myosin-independent traction regulated polymerizing actin assisted nucleators Arp2/3 and formin where a stronger contribution than to both flow. Intriguingly,...
Endothelial cells (ECs) within the vascular system encounter fluid shear stress (FSS). High, laminar FSS promotes vasodilation and anti-inflammatory responses, whereas low or disturbed induces dysfunction inflammation. However, adaptation of endothelial to dynamically changing patterns remains underexplored. Here, by combining traction force microscopy with a custom flow chamber, we examined human umbilical vein adapting their during transitions from short-term long-term high stress. We...
Within the vascular system, endothelial cells (ECs) are exposed to fluid shear stress (FSS), a mechanical force exerted by blood flow that is critical for regulating cellular tension and maintaining homeostasis. The way ECs react FSS varies significantly; while high, laminar supports vasodilation suppresses inflammation, low or disturbed can lead dysfunction increase risk of cardiovascular diseases. Yet, adaptation dynamically varying remains poorly understood. This study focuses on dynamic...