A5008965047- Synthesis and Characterization of Heterocyclic Compounds
- Quinazolinone synthesis and applications
- Cancer therapeutics and mechanisms
- DNA Repair Mechanisms
- Phytochemicals and Antioxidant Activities
- Synthesis and biological activity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Organophosphorus compounds synthesis
- Synthesis and Biological Evaluation
- Nanoparticle-Based Drug Delivery
- Bioactive Compounds and Antitumor Agents
- Metal complexes synthesis and properties
- Plant Genetic and Mutation Studies
- Medicinal plant effects and applications
- Soybean genetics and cultivation
- Vitamin C and Antioxidants Research
- Toxin Mechanisms and Immunotoxins
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Phytoestrogen effects and research
- Chemotherapy-induced organ toxicity mitigation
- Sirtuins and Resveratrol in Medicine
- DNA and Nucleic Acid Chemistry
- Phytochemical and Pharmacological Studies
University of Łódź
2016-2025
Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides constitute a novel class of heterocyclic compounds with broad biological activity, including anticancer properties. Investigated in this study, MM-compounds (MM134, MM136, MM137, and MM139) exhibited cytotoxic proapoptotic activity against cancer cell lines (BxPC-3, PC-3, HCT-116) nanomolar concentrations without causing cytotoxicity normal cells (L929 WI38). In silico predictions indicate that tested exhibit favorable...
Neurodegenerative diseases (Alzheimer’s disease, Parkinson’s Huntington’s and others) cancer, seemingly disparate in their etiology manifestation, exhibit intriguing associations certain cellular molecular processes. Both cancer neurodegenerative involve the deregulation of processes such as apoptosis, proliferation, DNA repair pose a significant global health challenge. Afzelin (kaempferol 3-O-rhamnoside) is flavonoid compound abundant various plant sources. exhibits diverse range...
Coronavirus Disease-2019 (COVID-19) is a highly contagious disease caused by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). The World Health Organization (WHO) classified the as global public health hazard on 11 March 2020. Currently, there are no adequate measures to combat viral infections, including COVID-19, and medication guidelines for management of COVID-19 dependent previous findings from SARS-CoV MERS-CoV research. Natural products have achieved widespread acceptance...
This study aimed to determine the health-promoting properties of sweet pepper by comparing activity fractions with variable lipophilicity. Fractions from red pericarp: aqueous (F1), 40% MeOH (F2), and 70% (F3) were analyzed for antiradical (with DPPH• ABTS+•), contents total phenolic compounds (TP), flavonoids (TF), dihydroxycinnamic acids (TDHCA). The anticancer potential was evaluated in vitro using different cancer cell lines: human colorectal carcinoma (HCT116) PC-3 (prostate cell)....