A5065212188- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Genomics and Diagnostics
- Hippo pathway signaling and YAP/TAZ
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Complement system in diseases
- Chemokine receptors and signaling
- Retinal Diseases and Treatments
- Cancer-related molecular mechanisms research
- Retinal Development and Disorders
- Immune Response and Inflammation
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
Inserm
2024
Université Paris-Saclay
2024
Institut Curie
2023-2024
Centre National de la Recherche Scientifique
2024
Sanquin
2020-2023
University of Amsterdam
2020-2023
Abstract Glioblastoma (GBM) is a highly lethal type of cancer. GBM recurrence following chemoradiation typically attributed to the regrowth invasive and resistant cells. Therefore, there pressing need gain deeper understanding mechanisms underlying resistance its ability infiltrate. Using combination transcriptomic, proteomic, phosphoproteomic analyses, longitudinal imaging, organotypic cultures, functional assays, animal studies, clinical data we demonstrate that brain vasculature induce...
Sprouting angiogenesis is key to many pathophysiological conditions, and strongly regulated by vascular endothelial growth factor (VEGF) signaling through VEGF receptor 2 (VEGFR2). Here we report that the early endosomal GTPase Rab5C its activator RIN2 prevent lysosomal routing degradation of VEGF-bound, internalized VEGFR2 in human cells. Stabilization levels RIN2/Rab5C crucial for ERK PI3-K pathways, expression immediate target genes, as well specification angiogenic 'tip' 'stalk' cell...
Cancer is one of the leading causes death worldwide. Treatment outcome largely dictated by tumor type, disease stage, and treatment success rates, but also variation among patients in endogenous anti-tumor responses. Studies indicate that presence neutrophils microenvironment associated with a worse patient due to their ability suppress local T cell activity. Our previous studies investigated mechanisms which damage cells become smaller size (small cells), debilitating effector activities....
Human neutrophils exert a well-known role as efficient effector cells to kill pathogenic micro-organisms. Apart from their in innate immunity, also have the capacity suppress T cell-mediated immune responses so-called granulocyte-myeloid-derived suppressor (g-MDSCs), impacting clinical outcome of various disease settings such cancer. Patients undergoing chemotherapy because an underlying malignancy can develop prolonged bone marrow suppression and are prone serious infections severe...
Abstract BACKGROUND Glioblastoma (GB) is one of the deadliest types human cancer. Despite a very aggressive treatment regime, including resection tumor, radiation, and chemotherapy, recurrence rate more than 90%. Recurrence mostly caused by regrowth highly invasive resistant cells that have spread from tumor bulk are not removed resection. To develop an effective therapeutic approach, we need to better understand underlying molecular cellular mechanisms GB chemoradiation resistance...
Abstract Glioblastoma (GB) is one of the deadliest types human cancer. Despite a very aggressive treatment regime-including resection, chemo-radiation, its recurrence rate more than 90%. Recurrence mostly caused by highly resistant and invasive cells that spread from tumor bulk are not removed resection. To develop an effective therapeutic approach, we need to better understand underlying molecular cellular mechanism driving therapy resistance invasion in GB. dynamically track changes...