A5068035090- Genetic and phenotypic traits in livestock
- Genetic diversity and population structure
- Diabetes and associated disorders
- Wildlife Ecology and Conservation
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Ecology and biodiversity studies
- T-cell and B-cell Immunology
- Microbial infections and disease research
- Pancreatic and Hepatic Oncology Research
- Animal Disease Management and Epidemiology
- Rangeland Management and Livestock Ecology
- Cancer-related molecular mechanisms research
- melanin and skin pigmentation
Trent University
2022-2024
SIB Swiss Institute of Bioinformatics
2020-2021
University of Neuchâtel
2020-2021
The glacial cycles of the Quaternary heavily impacted species through successions population contractions and expansions. Similarly, populations have been intensely shaped by human pressures such as unregulated hunting land use changes. White-tailed mule deer survived in different refugia Last Glacial Maximum, their were severely reduced after European colonization. Here, we analyzed 73 resequenced genomes from across North American range to understand consequences climatic anthropogenic on...
Abstract Under the ecological speciation model, divergent selection acts on differences between populations, gradually creating barriers to gene flow and ultimately leading reproductive isolation. Hybridisation is part of this continuum can both promote inhibit process. Here, we used white‐tailed ( Odocoileus virginianus ) mule deer O. hemionus investigate patterns in hybridizing sister species. We quantified genome‐wide historical introgression performed genome scans look for signatures...
Polymorphism for immune functions can explain significant variation in health and reproductive success within species. Drastic loss genetic diversity at such loci constitutes an extinction risk should be monitored species of conservation concern. However, effective implementations genome-wide polymorphism sets into high-throughput genotyping assays are scarce. Here, we report the design validation a microfluidics-based amplicon sequencing assay to comprehensively capture Alpine ibex (Capra...
Abstract The glacial cycles of the Quaternary heavily impacted species through successions population contractions and expansions. Similarly, populations have been intensely shaped by human pressures such as unregulated hunting land use changes. White-tailed mule deer survived in different refugia Last Glacial Maximum, their were severely reduced after European colonisation. Here, we analysed 73 re-sequenced genomes from across North American range to understand consequences climatic...
Abstract When a population is isolated and composed of few individuals, genetic drift the paramount evolutionary force that results in loss diversity. Inbreeding might also occur, resulting genomic regions are identical by descent, manifesting as runs homozygosity (ROHs) expression recessive traits. Likewise, genes underlying traits interest can be revealed comparing fixed SNPs divergent haplotypes between affected unaffected individuals. Populations white-tailed deer ( Odocoileus...
Abstract Under the ecological speciation model, divergent selection acts on differences between populations, gradually creating barriers to gene flow and ultimately leading reproductive isolation. Hybridisation is part of this continuum can both promote inhibit process. Here, we used white-tailed ( Odocoileus virginianus ) mule deer O. hemionus investigate patterns in hybridising sister species. We quantified genome-wide historical introgression performed genome scans look for signatures...
Abstract Genetic variation is a major factor determining susceptibility to diseases. Polymorphism at the histocompatibility complex (MHC) and other immune function loci can underlie health reproductive success of individuals. Endangered species low population size could be severely compromised evolve disease resistance due reduced adaptive variation. A impediment screen genetic in wild difficulty comprehensively genotype immune-related based on input material. Here, we design validate...
Abstract Existing studies do not sufficiently describe the molecular changes of pancreatic islet beta cells leading to their deficient insulin secretion in type 2 diabetes (T2D). Here we address this deficiency with a comprehensive multi-omics analysis metabolically profiled pancreatectomized living human donors stratified along glycemic continuum from normoglycemia T2D. Islet pools isolated surgical samples by laser-capture microdissection had remarkably heterogeneous transcriptomic and...
Abstract Remission of type 2 diabetes (T2D) may occur after very low-calorie diets or bariatric surgery, and is associated with improved pancreatic beta cell function. Here, we evaluated if T2D dysfunction can be rescued ex-vivo which are the molecular mechanisms involved. Islets from 19 donors were studied isolation (“basal”) following culture at 5.5 11.1 mmol/l glucose (“cultured”). We glucose-stimulated insulin secretion (GSIS) transcriptomes by RNA sequencing, correlated changes...