A5019767068- Liver Disease Diagnosis and Treatment
- Coffee research and impacts
- Hepatitis C virus research
- RNA and protein synthesis mechanisms
- Extracellular vesicles in disease
- Computational Drug Discovery Methods
- Protein Structure and Dynamics
- Viral Infections and Immunology Research
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Machine Learning in Bioinformatics
- Acute Myeloid Leukemia Research
- Graphene and Nanomaterials Applications
- Liver Disease and Transplantation
- Adenosine and Purinergic Signaling
- Telomeres, Telomerase, and Senescence
- Flavonoids in Medical Research
- Nanoparticles: synthesis and applications
- Bioinformatics and Genomic Networks
- Public Policy and Governance
- Liver physiology and pathology
- Molecular Biology Techniques and Applications
- Cannabis and Cannabinoid Research
- Tea Polyphenols and Effects
- Myeloproliferative Neoplasms: Diagnosis and Treatment
University of Groningen
2021-2025
Universidad de Antioquia
2018-2025
University Medical Center Groningen
2021-2024
Instituto Tecnológico Metropolitano
2013-2019
Metabolic dysfunction associated with steatotic liver disease (MASLD) is the result of disturbed lipid metabolism. In MASLD, accumulation free fatty acids (FFAs) in hepatocytes causes lipotoxicity mediated by oxidative stress. Coffee compounds are known for their beneficial effects MASLD; however, mechanisms still need to be further explored. The aim this study was elucidate protective coffee against palmitate-induced primary hepatocytes. Primary were isolated from male Wistar rats and...
Liver sinusoidal endothelial cells (LSECs) play a crucial role in maintaining liver microcirculation and exchange of nutrients the are thought to be involved pathogenesis metabolic dysfunction-associated steatotic disease (MASLD). The activation hepatic stellate (HSCs) Kupffer (KCs) has been considered responsible for onset fibrosis aggravation injury. However, paracrine regulatory effects LSECs development MASLD, particular LSEC-derived extracellular vesicles (EVs) remains unclear....
The Wnt/β-Catenin pathway alterations present in colorectal cancer (CRC) are of special interest the development new therapeutic strategies to impact carcinogenesis and progression CRC. In this context, different polyphenols natural products have been reported modulatory effects against Wnt study, we evaluate effect two polyphenol-rich coffee extracts chlorogenic acid (CGA) SW480 HT-29 CRC cells. This involved use MTT SRB techniques for cell viability; wound healing invasion assay evaluation...
Epidemiological evidence has shown an association between coffee consumption and reduced risk for chronic liver diseases, including metabolic-dysfunction-associated disease (MALFD). Lipotoxicity is a key cause of hepatocyte injury during MAFLD. The component caffeine known to modulate adenosine receptor signaling via the antagonism receptors. involvement these receptors in prevention hepatic lipotoxicity not yet been explored. aim this study was explore whether protects against...
Several fatty acids, in particular saturated acids like palmitic acid, cause lipotoxicity the context of non-alcoholic liver disease . Unsaturated (e.g. oleic acid) protect against hepatocytes. However, effect acid on other cell types, sinusoidal endothelial cells (LSECs), is unknown. Human umbilical vein (HUVECs) are often used as a substitute for LSECs, however, because unique phenotype HUVECs cannot represent same biological features LSECs. In this study, we investigate effects oleate and...
Activated hepatic stellate cells (aHSCs) are the main effector during liver fibrogenesis. α-1 adrenergic antagonist doxazosin (DX) was shown to be anti-fibrotic in an vivo model of fibrosis (LF), but mechanism remains elucidated. Recent studies suggest that reversion LF can achieved by inducing cellular senescence characterized irreversible cell-cycle arrest and acquisition senescence-associated secretory phenotype (SASP).To elucidate effect DX determine whether it induces senescence.Primary...
Cancer is a complex and evolving disease that the leading cause of death in twenty-first century, colorectal liver cancers specifically are top 10 cancer types terms incidence mortality; therefore, there has been shift towards researching prevention strategies, amongst which chemoprevention key. Coffee natural product recently gained importance this area due to its chemopreventive potential high level consumption worldwide. In review, recent epidemiological experimental evidence effect...
This comprehensive review focuses on the dynamics of branched-chain amino acids (BCAAs) metabolism and its clinical implications in chronic liver disease, with emphasis emerging concept muscle–liver crosstalk. BCAAs, indispensable for protein synthesis metabolic pathways, undergo unique tissue-specific processing skeletal muscle liver. The liver, responsible acid metabolism, plays a distinctive role sensing BCAAs catabolism, influencing glucose regulation contributing to systemic BCAAs....
The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing rapidly worldwide due to the obesity epidemic. Advanced stages MAFLD, such as non-alcoholic steatohepatitis (NASH) with advanced fibrosis or cirrhosis are affecting global health. Extracellular vesicles (EVs) released by all cell types and important in cell-to-cell communication maintaining homeostasis, but they also play a role pathogenesis various diseases. EVs contain biological information...
Introducción: la infección por el virus de hepatitis C es un problema salud pública. Según datos Organización Mundial Salud, se estiman 184 millones casos VHC en mundo. El principal factor riesgo países desarrollo corresponde a transfusión componentes sanguíneos. En Colombia, 1993, reglamentó tamizaje serológico los bancos sangre para diferentes agentes infecciosos, incluido VHC; sin embargo, población transfundida antes esta fecha limitada.
 Objetivo: describir frecuencia una...
Many proteins can interact with other to perform specific functions. Predicting those interactions is important in order analyze signaling pathways or define the influence of a protein some diseases. This work proposes implementation Support Vector Machines (SVM) for prediction protein-protein using physical-chemical features taken from AA index. algorithm was trained set over 10.000 positive DIP database, and same number negative through random permutations. The obtained results demonstrate...
The human pegivirus (HPgV), classified in the Flaviviridae family - Pegivirus genus, is an RNA virus identified 1995. HPgV a lymphotrophic virus, with replication sites bone marrow and lymphoid tissue, as well peripheral blood mononuclear cells (PBMCs). Transmission through sexual parenteral routes, recent estimations suggest nearly 750 million people are infected worldwide. Almost 25% of individuals can develop persistent infection. Until now, has been considered non-pathogenic virus;...
It has been shown that the antidiabetic drug metformin protects hepatocytes against toxicity by various stressors. Chronic or excessive consumption of diclofenac (DF) - a pain-relieving drug, leads to drug-induced liver injury via mechanism involving mitochondrial damage and ultimately apoptotic death hepatocytes. However, whether DF-induced is unknown. Recently, it was also cAMP elevation protective in hepatocytes, effect primarily downstream effector EPAC preservation function. This study...
In this paper, a SVM-based method is implemented for the prediction of protein-protein interactions. This model initially trained with set over 69.000 pairs protein sequences based on documented positive Then, cross-validation performed estimating accuracy system, showing acceptable performances in terms sensitivity, specificity and geometric mean. The results are approximately balanced overall performance if around 70% classified through pairwise kernel parameters an particle swarm...
The Ribonucleic acid (RNA) is a key molecule in different cellular processes, including catalysis. These functions depend not only on nucleotide sequences but also of RNA secondary structure (2D) [1]; this the case extensively characterized IRES (Internal Ribosome Entry Site) Hepatitis C Virus (HCV) [2]. Although experimental techniques are available for studying molecular conformation and folding, their high cost limits more extended use, therefore bioinformatics programs currently used 2D...
Background: Acute myeloid leukemia (AML) is a malignant clonal disorder characterized by mutations affecting differentiation, gene expression, and epigenetic profiles. Although treatment strategy depends on genetic profile-based risk, the accuracy of this stratification system highly variable. Changes in expression profiles signaling pathways involved hematopoietic development, such as Wnt/B-catenin, may contribute to transformation, maintenance leukemic cells, could be related clinical...