A5101604600- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Cancer Immunotherapy and Biomarkers
- Amino Acid Enzymes and Metabolism
- Nanoplatforms for cancer theranostics
- Adenosine and Purinergic Signaling
- RNA Interference and Gene Delivery
- ATP Synthase and ATPases Research
- Cancer-related Molecular Pathways
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Cyclopropane Reaction Mechanisms
- Microwave Engineering and Waveguides
- Bioactive Compounds and Antitumor Agents
- Antioxidant Activity and Oxidative Stress
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Catalytic Cross-Coupling Reactions
- Glycosylation and Glycoproteins Research
Yantai University
2025
Ministry of Education of the People's Republic of China
2025
Tianjin Medical University Cancer Institute and Hospital
2020-2024
China Medical University
2024
First Affiliated Hospital of Zhengzhou University
2023
Army Medical University
2021-2022
Jilin University
2021-2022
Harbin Medical University
2021
First Affiliated Hospital of Harbin Medical University
2021
Shanxi Medical University
2014
Abstract Laryngeal squamous cell carcinoma (LSCC) is a malignant tumor with high probability of metastasis. The microenvironment (TME) plays critical role in cancer To gain insights into the TME LSCC, we conducted single-cell RNA-seq (scRNA-seq) on samples collected from LSCC patients or without lymphatic stem and immune signatures suggest their roles invasion Infiltration large number regulatory T cells, dysplastic plasma macrophages that are at early development stage cancerous tissue...
A Cu-promoted highly chemoselective dimerization of 5-aminopyrazoles to produce pyrazole-fused pyridazines and pyrazines is reported. The protocol generates switchable products via the direct coupling C-H/N-H, C-H/C-H N-H/N-H bonds, with merits broad substrate scope high functional group compatibility. Gram-scale experiments demonstrated potential applications this reaction. Moreover, preliminary fluorescence results uncovered that dipyrazole-fused may have some in materials chemistry.
A palladium/norbornene (NBE)-catalyzed 2-fold C-H/C-X coupling reaction of aryl iodides is reported. Bromine-substituted benzimidazoles were chosen as electrophilic and termination reagents, the versatile polycyclic aromatic hydrocarbon products successfully obtained. The strategy overcomes challenge catalyst poisoning by heterocyclic substrates. In addition, imidazole moiety in product endowed with a localization role, thus enabling compounds to be applied wider synthetic scenario,...
Colon adenocarcinoma (COAD) is one of the diseases with highest morbidity and mortality in world. At present, immunotherapy has become a valuable method for treatment COAD. Tumor mutational burden (TMB) considered to be most common biomarker predicting immunotherapy. According reports, mutation rate COAD ranks third. However, whether these gene mutations are related TMB immune response still unknown. Here, somatic data were downloaded from The Cancer Genome Atlas (TCGA) International...
Breast cancer (BRCA) is the most common malignant tumor among women worldwide. Despite advances in treatment, many patients still die from a lack of effective diagnostic and prognostic markers powerful therapeutic targets. LIM homeobox genes (LHXs) play vital roles regulating development various organisms. However, there are limited reports regarding their diagnosis, prognosis, treatment BRCA.
A feature of the composite right/left-handed (CRLH) transmission line is zeroth-order resonance. This property can be used to create a novel band-pass filter. Comparing with traditional filter, center frequency filter presented here independent on size and loss relatively low. The experimental result are in good agreement simulation result.
Objective To observe the expression of cytokeratin 14,15 (CK14,CK15) level in normal esophageal tissues and squamous cell carcinoma different differentiation degree to analyze relationship between occurrence,development CK14,CK15 level.Methods Esophageal epithelial tissue from 55 cases adjacent were collected.Immunohistochemical method was used compare PCNA levels carcinoma.Results Expression positive rates 72.7 ％ (40/55),63.6 (35/55) 65.5 (36/55),respectively,and correlated with CK14 or...