ABSTRACT Redox‐responsive core cross‐linked (CCL) micelles of poly(ethylene oxide)‐ b ‐poly(furfuryl methacrylate) (PEO‐ ‐PFMA) block copolymers were prepared by the Diels‐Alder click‐type reaction. First, PEO‐ ‐PFMA amphiphilic copolymer was synthesized reversible addition‐fragmentation chain transfer polymerization. The hydrophobic blocks PFMA employed to encapsulate doxorubicin (DOX) drug, and they using dithiobismaleimidoethane at 60 °C without any catalyst. Under physiological...

The rapid rise in temperature due to climate change has raised concerns about its impact on the keystone species Crangon hakodatei East Sea of Korea. However, no studies have examined population characteristics C. or response along coast. In this study, we investigated these aspects using year-round sampling and environmental data collected east coast South A positive correlation was observed between shrimp abundance temperature. Specifically, both growth reproductive were affected by...

Thorium-234 (234Th; half-life = 24.1 days) has been used as an excellent tracer for estimating particle fluxes, including particulate organic carbon (POC) and trace elements, in the upper ocean. In this study, distributions of total phases 234Th (234Thtand 234Thp), POC, other oceanographic parameters (temperature, salinity, chlorophyll-a) were investigated North Equatorial Currents (NEC) during September 21-27, 2024. The study region, located within ; 13.5˚N 134-157˚E, is...

Aspects of the reproductive biology crangonid shrimp Philocheras trispinosus were studied. Size female maturity was determined from proportions ovigerous females and with maturing ovaries. The size at which 50% are mature is estimated (±95% confidence intervals) as 3.69 ± 0.56-mm carapace length. Brood weight fecundity related isometrically body size. Based on dry weight, output (mass incubating eggs/mass female) averaged 0.24. main spawning season (percentage > 50%), March-August, reflected...

The growth and reproductive biology of the freshwater shrimp Exopalaemon modestus were studied in Young-am Lake, Korea, from January to December 1999. Female maturity was determined by size ovigerous females with maturing ovary. at which 50% are mature is estimated as 11.55 ± 1.95 mm carapace length. Brood isometric functions female body size. Based on dry weight, output (mass incubating eggs/mass female) averaged 0.17. Ovigerous occurred May–September. Higher gonad index observed May–June...

Hepatocellular carcinoma (HCC) is one of the most aggressive malignant diseases and highly resistant to conventional chemotherapy. Therefore, HCC requires more effective prevention treatment strategies. 5-fluorouracil (5-FU) remains widely used chemotherapeutic drug for gastrointestinal, breast, head neck, ovarian cancers. In pursuit a novel strategy, we have evaluated potential 5-FU promote endoplasmic reticulum (ER) stress autophagy in Sk-Hep1 cells. We found that profoundly induces ER...

Sargassum serratifolium was found to contain high concentrations of meroterpenoids, having strong antioxidant, anti-inflammatory, and neuroprotective activities. This study aims investigate the anti-inflammatory mechanisms an ethanolic extract S. (ESS) using lipopolysaccharide (LPS)-stimulated BV2 microglial cells identify components in ESS. The level proinflammatory cytokines measured by enzyme-linked immunosorbent assay. expression inflammation-related proteins mRNA evaluated Western blot...

The growth and reproductive biology of the freshwater shrimp Exopalaemon modestus were studied in Young-am Lake, Korea, from January to December 1999. Female maturity was determined by size ovigerous females with maturing ovary. at which 50% are mature is estimated as |$11.55 \pm 1.95 \ {\rm mm}$| carapace length. Brood isometric functions female body size. Based on dry weight, output (mass incubating eggs/mass female) averaged 0.17. Ovigerous occurred May–September. Higher gonad index...

Sargaquinoic acid (SQA) has been known for its antioxidant and anti-inflammatory properties. This study investigated the effects of SQA isolated from Sargassum serratifolium on inhibition tumor necrosis factor (TNF)-α-induced monocyte adhesion to human umbilical vein endothelial cells (HUVECs). decreased expression cell molecules such as intracellular molecule-1 vascular well chemotactic cytokines interleukin-8 chemoattractant protein-1 in TNF-α-treated HUVECs. As a result, prevented...

Sargassum species have been reported to be a source of phytochemicals, with wide range biological activities. In this study, we evaluated the hepatoprotective effect meroterpenoid-rich fraction ethanolic extract from serratifolium (MES) against tert-butyl hydroperoxide (t-BHP)-treated HepG2 cells. Treatment MES recovered cell viability t-BHP-induced oxidative damage in dose-dependent manner. It suppressed reactive oxygen production, lipid peroxidation, and glutathione depletion t-BHP-treated...

ABSTRACT Preclinical Research Hepatocellular carcinoma (HCC) is one of the most malignant and frequent cancers with a high metastatic potential. The prevention HCC metastasis critical target for effective therapies in HCC. Gambogic acid (GA), natural compound obtained from Garcinia hanburyi has reported anticancer activity cell lines. However, antimetastatic mechanisms GA are unclear, particularly respect to In this study, influence on migration invasion SK‐HEP1 cells was evaluated. At...