A5041585810- Systemic Lupus Erythematosus Research
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Pregnancy and Medication Impact
- Cardiovascular Issues in Pregnancy
- Blood Coagulation and Thrombosis Mechanisms
- Maternal and Neonatal Healthcare
- Renal Diseases and Glomerulopathies
- Parvovirus B19 Infection Studies
- Global Maternal and Child Health
- Fatty Acid Research and Health
- Gestational Diabetes Research and Management
- Congenital Heart Disease Studies
- Birth, Development, and Health
- Heme Oxygenase-1 and Carbon Monoxide
- Lipid metabolism and disorders
- Maternal and fetal healthcare
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- Maternal and Perinatal Health Interventions
- Toxoplasma gondii Research Studies
- Ectopic Pregnancy Diagnosis and Management
- Venous Thromboembolism Diagnosis and Management
- Cytomegalovirus and herpesvirus research
- Prenatal Substance Exposure Effects
Universidade do Estado do Rio de Janeiro
2015-2025
Hospital Universitário Pedro Ernesto
2018-2025
Universidade Federal do Rio de Janeiro
2020-2022
Fundação Oswaldo Cruz
2016
Altera (United States)
2014
We conducted a randomized, controlled study to assess the need for hydroxychloroquine (HCQ) during lupus pregnancy and safety. Twenty consecutive pregnant patients with similar characteristics were enrolled. The HCQ group included eight systemic erythematosus (SLE) two discoid (DLE). placebo (PL) nine SLE one DLE. had no flare-ups. SLEPDAI scores at entry, conclusion significantly higher scores. One patient improvement of skin lesions another arthritis, allowing decrease prednisone dose....
Consumption of alcoholic beverages during pregnancy is directly related to the establishment fetal alcohol spectrum disorders (FASD), which includes craniofacial changes, body growth restriction, and neurodevelopment impairments. Proper functioning central nervous system (CNS) depends on blood-brain barrier (BBB) development, formed by interactions vascular endothelial cells, pericytes, astrocytes, basal lamina. Gestational exposure ethanol has been demonstrated impair CNS development;...
To analyze the impact of different classes lupus nephritis as risk variables for maternal and fetal adverse outcomes in a cohort pregnant patients.This is study with retrospective prospective data collection, conducted at University Hospital State Rio de Janeiro, Brazil, from 2011 to 2016. A total 147 pregnancies 137 systemic erythematosus patients whom 66 had were included. Demographic clinical features, well observed each histological class among compared those without nephritis....
Objective This study analyzed longitudinal trajectories of soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and placental growth factor (PlGF) sFlt‐1/PlGF ratio in a cohort pregnant patients with systemic lupus erythematosus (SLE). Methods Blood samples were collected (14‐18, 24‐26, 30‐32, 34‐36 38‐40 weeks), stored at ‐80°C evaluated for serum levels sFlt‐1, PlGF sFlt1/PlGF ratios. Patients classified as inactive SLE (SLEPDAI < 4), active disease > or preeclampsia (PE). Medians...
Objective To evaluate mean serum levels of vascular endothelial growth factor (VEGF), placental (PlGF), and soluble Flt‐1 (sFlt‐1) in pregnant patients with systemic lupus erythematosus (SLE) inactive disease, active nephritis, preeclampsia for differential diagnosis between these conditions. Methods Pregnant women SLE, singleton pregnancies no other autoimmune diseases, were classified according to disease activity (inactive SLE nephritis) the presence preeclampsia. Serum samples collected...
What is already known about this topic? Lower urinary tract obstruction associated with high morbidity and mortality. Fetal cystoscopy may allow the correct identification of etiology provide adequate treatment. does study add? Three‐dimensional virtual navigation a noninvasive approach that provides an immersive reality in assessment fetal structures. evaluation lower future help selection candidates for cystoscopy.
No Brasil, a prevalência de infecção aguda é aproximadamente 1-14 casos/ 1.000 nascidos vivos (NV) e congênita 0,2-2,0/1.000 NV. A toxoplasmose durante o período gestacional assintomática em mais 90% dos casos. Quando sintomática, consiste quadro gripal (febre, linfadenopatia mal estar) similar ao apresentado por não gestantes. clássica caracterizada pela tétrade: coriorretinite, hidrocefalia/microcefalia, calcificações cerebrais alteração neurológica. O rastreio para T. gondii deve ser...
This article describes three complicated cases in rheumatology and pregnancy. The first case elucidates the challenges treating SLE conjunction with pulmonary arterial hypertension, while second features an SLE-affected pregnancy development of portal hypertension secondary to vein thrombosis related APS. third is a pregnant woman stable who developed thrombotic microangiopathy caused by atypical haemolytic uraemic syndrome, failed improve despite multiple measures including biopsy elective...
A gravidez é uma condição fisiológica na qual ocorrem várias mudanças imunoendócrinas com a finalidade de facilitar imunossupressão e tolerância aos antígenos paternos fetais. Na humana normal existe relativa supressão citocinas tipo Th1 resposta dos linfócitos, levando prevalência do Th2. No LES, onde prevalece imune Th2, pode estar relacionada ativação da doença. Este artigo revisão dessas alterações relacionadas durante gestação paciente LES.
SUMMARY OBJECTIVE: The aim of this study was to analyze the occurrence and risk factors associated with infections during pregnancy in patients systemic lupus erythematosus. METHODS: This is a retrospective cohort using data pregnant women who were followed up between 2011 2018 at university hospital. RESULTS: 221 erythematosus analyzed. incidence 22.6% (50/221), urinary tract being most frequent site infection (32/221, 14.5%) by respiratory (15/221, 6.8%). bivariate analysis showed that...
OBJETIVO: avaliar o impacto da nefrite lúpica e suas complicações nos resultados gestacionais. MÉTODOS: avaliamos retrospectivamente 76 gestações em 63 pacientes com lúpus eritematoso sistêmico (LES). RESULTADOS: a hipertensão arterial estava presente como complicação clínica 23 (30%) gestações. Vinte sete (36%) ocorreram 19 nefrite. Encontramos um número significativamente mais elevado de óbitos fetais quando todas as comparação aquelas sem (37% 12,2%, respectivamente [p=0,019])....
The objective of this study was to evaluate the potential impact irreversible damage accrual in women with systemic lupus erythematosus (SLE) and adverse maternal and/or fetal/neonatal outcomes.Retrospective cohort SLE pregnant patients carried out from January 2011 2020 at Hospital University Pedro Ernesto (HUPE) State Rio de Janeiro, Brazil. Irreversible defined according SLICC/ACR index (SDI). association SDI on pregnancy outcomes established by univariate multivariate regression models...