A5041248574- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Multicomponent Synthesis of Heterocycles
- Computational Drug Discovery Methods
- Metal complexes synthesis and properties
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Free Radicals and Antioxidants
- Cancer therapeutics and mechanisms
- Corrosion Behavior and Inhibition
- Electrochemical Analysis and Applications
- Natural Antidiabetic Agents Studies
- Quinazolinone synthesis and applications
- Synthesis of heterocyclic compounds
- Synthesis of Organic Compounds
- Nanomaterials for catalytic reactions
- Advanced Photocatalysis Techniques
- TiO2 Photocatalysis and Solar Cells
- Nonlinear Optical Materials Research
- Inflammatory mediators and NSAID effects
- Crystallization and Solubility Studies
- Concrete Corrosion and Durability
- Photochromic and Fluorescence Chemistry
- Biochemical and Molecular Research
Al-Azhar University
2016-2025
Al Baha University
2015-2025
Al-Azhar University
2019-2025
Université Ibn-Tofail
2024
King Saud University
2024
Sivas Cumhuriyet Üniversitesi
2024
Université Moulay Ismail de Meknes
2024
Bridge University
2024
Aliah University
2024
Taif University
2020
Acacia polyacanthagum(Kakamut gum) samples were collected as natural exudates, from three different locations in Sudan named Abugarin, Gargadah and Layoon forest. Physicochemical properties of gum studied (moisture , ash ,nitrogen protein, specific rotation, intrinsic viscosity refractive index, equivalent weight, pH uronic acid reducing sugars . Results showed significant differences within each location most parameters studied, index values found to be constant all (1.3337) The effect on...
Urease belongs to the family of amid hydrolases with two nickel atoms in their core structure. On basis literature survey, this research work is mainly focused on study bis-Schiff base derivatives benzyl phenyl ketone nucleus.Synthesis based bases search potent urease inhibitors.In current work, were synthesized through steps reaction by reacting excess hydrazine hydrate ethanol solvent first step get desired hydrazone. In last, different substituted aromatic aldehydes refluxed catalytic...
Schistosomiasis is a tropical disease with socioeconomic problems. The goal of this study was to determine the influence myco-synthesized nano-selenium (SeNPs) as molluscicide on Biomphlaria alexandrina snails, reducing spread via non-toxic routes. In study, Penicillium chrysogenum culture filtrate metabolites were used reductant for selenium ions form nano-selenium. SeNPs characterized UV-Vis spectrophotometer, Fourier transform infrared (FT-IR) spectroscopy, transmission electron...
Abstract In the current research work novel bis ‐Schiff base products of benzyl phenyl ketone nucleus were synthesized via two step reactions in excellent yields. Using FTIR, EI‐MS and 1 H‐NMR spectroscopic procedures, structures derivatives confirmed finally evaluated them for DPPH free radical scavenging activity. synthetic series, compounds 2 c (IC 50 =26.11±0.12 μ M), b =30.33±0.22 d =38.19±0.65 a =40.12±0.42 M) exhibited activity better than standard drug ascorbic acid =44.01±1.41 while...
Semisynthetic modifications of natural products have bestowed us with many anticancer drugs. In the present work, a product, eugenol, has been modified synthetically to generate new agents. The final compounds were structurally confirmed by NMR, IR, and mass techniques. From cytotoxicity results, compound 17 bearing morpholine was found be most active cytotoxic agent IC50 1.71 (MCF-7), 1.84 (SKOV3), 1.1 μM (PC-3) thymidylate synthase (TS) inhibitor an 0.81 μM. Further cellular studies showed...
Benzofuran and 1,3,4-oxadiazole are privileged versatile heterocyclic pharmacophores which display a broad spectrum of biological pharmacological therapeutic potential against wide variety diseases. This article reports in silico CADD (computer-aided drug design) molecular hybridization approaches for the evaluation chemotherapeutic efficacy 16 S-linked N-phenyl acetamide moiety containing benzofuran-1,3,4-oxadiazole scaffolds BF1-BF16. virtual screening was carried out to discover assess...
This research work reports the synthesis of new derivatives hydrazone Schiff bases (1–17) based on polyhydroquinoline nucleus through multistep reactions. HR-ESIMS,1H- and 13C-NMR spectroscopy were used to structurally infer all synthesized compounds lastly evaluated for prolyl oligopeptidase inhibitory activity. All prepared products displayed good excellent activity when compared with standard z-prolyl-prolinal. Three 3, 15 14 showed inhibition IC50 values 3.21 ± 0.15 5.67 0.18 µM, while...
Abstract P -glycoprotein ( -gp) imparts multi-drug resistance (MDR) on the cancers cell and malignant tumor clinical therapeutics. We report a class of newly designed synthesized oxygen-heterocyclic-based pyran analogues (4a–l) bearing different aryl/hetaryl-substituted at 1-postion were synthesized, aiming to impede -gp function. These compounds 4a–l ) have been tested against cancerous PC-3, SKOV-3, HeLa, MCF-7/ADR lines as well non-cancerous HFL-1 WI-38 determine their anti-proliferative...
A series of the 2-hydroxy-3-iodo-5-nitrochalcones 3a–n was synthesized and characterized spectroscopically (FT-IR, ESI-MS, 1H-NMR, 13C-NMR) complemented with single crystal X-ray diffraction analysis. The compounds were, in turn, subjected to an vitro cytotoxicity study against human lung (A549) breast (MCF-7) cancer cell lines as well embryonic kidney (HEK293-T) line using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. test exhibited moderate A549 compared staurosporine...
Abstract The process of creating a series 3-amino-1-aryl-8-methoxy-1 H -benzo[ f ]chromene-2-carbonitriles ( 4a-q ) involved reacting 6-methoxynaphthalen-2-ol 1 ), the appropriate aromatic aldehydes 2a-q and malononitrile 3 in an absolute ethanol/piperidine solution under Ultrasonic irradiation. However, attempt to create 3-amino-1-aryl-1 ]chromene-2,8-dicarbonitrile 6a, d, e was unsuccessful when 6-cyanonaphthalen-2-ol 5 stirred at room temperature, reflux, Microwave irradiation, or In...
Abstract This research work is based on synthesis of eleven novel thiazole derivatives (3 a‐k) thiophene carbaldehyde. All the synthesized compounds were successfully synthesized, characterized by 1 H‐NMR and EI‐MS spectroscopic techniques finally subjected for their in vitro α‐glucosidase inhibitory activity. Seven 3 i (IC 50 =10.21±1.84 μM) , b =11.14±0.99 f =13.21±2.76 h =14.21±0.31 k =15.21±1.02 e =16.21±1.32 μM), c =18.21±1.89 series displayed excellent potential better than standard...
Synthesis of 7-acetyl-2-aryl-5-nitrobenzofurans 2a–j involved sequential Sonogashira cross-coupling 2-hydroxy-3-iodo-5-nitroacetophenone with terminal acetylenes and in situ Cacchi-type cycloisomerization 5-alkynylated intermediates. Hirshfeld's fingerprint diagrams surface analysis showed varied intermolecular interactions. Additionally, intramolecular interactions were examined using DFT QTAIM calculations. Benzofuran derivatives tested for antiproliferative efficacy vitro against...
Thirteen novel hydrazone-Schiff bases (3-15) of fexofenadine were succesfully synthesized, structurally deduced and finally assessed their capability to inhibit urease enzyme (in vitro). In the series, six compounds 12 (IC
Abstract 3-Amino-1-(3,4-dimethoxyphenyl)-8-methoxy-1 H -benzo[ f ]chromene-2-carbonitrile (3-ABC, 4) was prepared and affirmed through the spectral data single crystal X-rays diffraction. The molecule spatial attributes were revealed by three-dimensional Hirshfeld surface, which is validated comprehensive statistical evaluations. key interactions that contribute to crystal's stability properties, such as π–π stacking H⋯X contacts, highlighted. dominant forces in explained energy framework...
Background: Due to the divers biological applications of Cu(II) complexes, we in this study reports various complexes. The aims synthesize and assess new complexes as powerful β-glucuronidase inhibitors. Methods: Five Schiff base ligands their were synthesized, characterized, screened against inhibitory activity. Results: In series, compounds 3e, 3c, 2b, 2c ascribed inhibition ranging from (IC50 = 3.0 ± 0.7 µM) 19.2 0.8 µM). A precise particular arrangement atoms is suggested by triclinic...
The inhibition impacts of two non-toxic glycine derivatives, namely, bicine (N,N-bis(2-hydroxyethyl)glycine) and tricine (N-(tri(hydroxymethyl)methyl) glycine) on copper corrosion were investigated in 3.5% NaCl solutions. Surprisingly, there is no report using and/or as inhibitors for Cu its alloys a seawater-like environment. effects the behavior examined open circuit potential, Tafel polarization, AC spectroscopy (EIS) techniques. rate decreased function inhibitor dose. EIS parameters...
SARS-CoV-2 is a pandemic virus that caused infections and deaths in many world countries, including the Middle East. The virus-infected human cells by binding via ACE-2 receptor through Spike protein of with Furin's help causing cell membrane fusion leading to Covid-19-cell entry. No registered drugs or vaccines are triggering this viral disease yet. Our present work based on molecular docking dynamics simulation performed spike protein-ACE-2 interface complex, receptor, (RBD), Furin as...
A library of novel naproxen based 1,3,4-oxadiazole derivatives (8–16 and 19–26) has been synthesized screened for cytotoxicity as EGFR inhibitors. Among the hybrids, compound2-(4-((5-((S)-1-(2-methoxynaphthalen-6-yl)ethyl)-1,3,4-oxadiazol-2-ylthio)methyl)-1H-1,2,3-triazol-1-yl)phenol(15) was most potent compound against MCF-7 HepG2cancer cells with IC50 2.13 1.63 µg/mL, respectively, equipotent to doxorubicin (IC50 1.62 µg/mL) towards HepG2. Furthermore, 15 inhibited kinase 0.41 μM compared...