A5073186988- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Circadian rhythm and melatonin
- Prion Diseases and Protein Misfolding
- Amyotrophic Lateral Sclerosis Research
Centro de Investigaciones Biológicas Margarita Salas
2022
Instituto Cajal
2022
Abstract Cognitive function relies on a balanced interplay between excitatory and inhibitory neurons (INs), but the impact of estradiol IN is not fully understood. Here, we characterize regulation hippocampal INs by aromatase, enzyme responsible for synthesis, using combination molecular, genetic, functional behavioral tools. The results show that CA1 parvalbumin-expressing (PV-INs) contribute to brain synthesis. Brain aromatase regulates synaptic inhibition through mechanism involves...
Alzheimer's disease (AD) is a neurodegenerative disorder for which there currently no effective treatment. Despite advances in the molecular pathology of characteristic histopathological markers (tau protein and β-amyloid), their translation to clinic has not provided expected results. Increasing evidences have demonstrated presence aggregates TDP-43 (TAR DNA binding 43) postmortem brains patients diagnosed with AD. The present research focused on study pathological role For this purpose,...