A5076997140- Nuclear Receptors and Signaling
- Airway Management and Intubation Techniques
- Nitric Oxide and Endothelin Effects
- Anesthesia and Sedative Agents
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Autism Spectrum Disorder Research
Massachusetts General Hospital
2022
Harvard University
2022
West Virginia University
2021
Parkinson's disease (PD) is characterized by the selective death of substantia nigra pars compacta (SNpc) dopaminergic neurons and includes both motor non-motor symptoms. While numerous models exist for study typical PD deficits, fewer Previous studies have shown that a Pitx3-/- mouse model (aphakia or ak mouse) has specific developmental failure neuron population in SNpc it can be used PD-related gross dysfunction as well cognitive functional deficits. It remains unclear whether aphakia...
Nitric oxide (NO) is a versatile free radical that has been implicated in many biological processes (i.e., vasodilation, neurotransmission, and smooth muscle relaxation). High levels of NO, such as those produced by inducible NO synthase, are associated with innate immunity well tissue damage disease pathology. Previous studies have characterized stimuli lead to production following central nervous system (CNS) infection, ischemia, during neurodegeneration, but less known about the effects...