A5051910891- Pulmonary Hypertension Research and Treatments
- Inflammasome and immune disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nitric Oxide and Endothelin Effects
- Angiogenesis and VEGF in Cancer
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- S100 Proteins and Annexins
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Neuroscience of respiration and sleep
- Heme Oxygenase-1 and Carbon Monoxide
- MicroRNA in disease regulation
- Neonatal Respiratory Health Research
- Lymphatic System and Diseases
- Psoriasis: Treatment and Pathogenesis
Universidad Autónoma de Madrid
2019-2023
Hospital Universitario de La Princesa
2019-2022
Exosomes, which are membrane-bound extracellular vesicles (EVs), generated in the endosomal compartment of almost all eukaryotic cells. They formed upon fusion multivesicular bodies and plasma membrane carry proteins, nucleic acids, lipids other cellular constituents from their parent Multiple factors influence production including cell stress injury, humoral factors, circulating toxins, oxidative stress. play an important role intercellular communication, through ability to transfer cargo...
Background Inflammasomes are cytosolic multiprotein complexes which, upon assembly, activate the maturation and secretion of inflammatory cytokines IL‐1β IL‐18. However, participation NLRP3 inflammasome in ischaemic stroke remains controversial. Our aims were to determine role brain ischaemia, explore mechanism involved potential protective effect neurovascular unit. Methods WT knock‐out mice subjected ischaemia by middle cerebral artery occlusion (60 min) with or without treatment MCC950 at...
Rationale: Cigarette smoke is considered the chief leading cause of chronic obstructive pulmonary disease (COPD). Its impact on progressive deterioration airways has been extensively studied, but its direct effects vasculature are less known. Objectives: To prove that arterial remodeling in patients with COPD not just a consequence alveolar hypoxia also due to cigarette vascular bed. Methods: We have used different molecular and cell biology approaches, as well traction force microscopy,...
Accumulating evidence on the role of Thrombospondin-1 (TSP-1) in immune response has emerged during last years. In spite importance TSP-1 not only as anti-angiogenic factor but also an immunomodulatory molecule, studies psoriasis have been neglected. and CD47 expression were analyzed skin samples from patients control subjects using RT-PCR immunofluorescence. Expression these molecules was evaluated peripheral blood CD4+ T cells, moDCs circulating primary DCs. The functional TSP-1/CD47...
Chronic obstructive pulmonary disease (COPD), whose main risk factor is cigarette smoking (CS), one of the most common diseases globally. Some COPD patients also develop hypertension (PH), a severe complication that leads to premature death. Evidence suggests reactive oxygen species (ROS) involvement in and PH, especially regarding artery smooth muscle cells (PASMC) dysfunction. However, effects CS-driven oxidative stress on vasculature are not completely understood. Herein we provide...
Abstract Thrombospondin-1 (TSP-1) is a multifunctional matrix protein with antitumor activities due in part to its ability inhibit angiogenesis, which turn contributes determine the fate of many tumours. Previous studies have shown that TSP-1 expression supports normal kidney angiostasis, and decreased levels contribute angiogenic phenotype renal cell carcinomas (RCC). The loss von Hippel-Lindau tumour suppressor gene ( VHL ) these tumours favours stabilization Hypoxia Inducible Factors...
Abstract Chronic obstructive pulmonary disease (COPD) is a widespread disease, with no curative therapies nowadays. Exposure to cigarette smoking considered the chief leading cause of COPD. Current drugs improve patient quality life, however they do not revert progression disease. Therefore, deeper study cellular and molecular mechanisms that underlie this pathology required be able carry out targeted effective treatments. Although effects smoke in progressive deterioration airway have been...
ABSTRACT Chronic obstructive pulmonary disease (COPD), whose main risk factor is cigarette smoking (CS), one of the most common diseases globally. Many COPD patients also develop hypertension (PH), a severe complication that leads to premature death. Evidence suggests reactive oxygen species (ROS) involvement in and PH, especially regarding artery smooth muscle cells (PASMC) dysfunction. However, effects CS on vasculature are not completely understood. Herein we provide evidence extract...
Background: Post-ischemic inflammation contributes to worsening of ischemic brain injury and in this process, the inflammasomes play a key role. Inflammasomes are cytosolic multiprotein complexes which upon assembly activate maturation secretion inflammatory cytokines IL-1β IL-18. However, participation NLRP3 inflammasome stroke remains controversial. Our aims were determine role ischemia explore mechanism involved potential protective effect neurovascular unit. Methods: WT knock-out mice...
Abstract Background and purpose Post-ischemic inflammation contributes to worsening of ischemic brain injury in this process, the inflammasomes play a key role. Inflammasomes are cytosolic multiprotein complexes which upon assembly activate maturation secretion inflammatory cytokines IL-1β IL-18. However, participation NLRP3 inflammasome stroke remains controversial. Our aims were determine role ischemia explore mechanism involved potential protective effect neurovascular unit. Methods WT...
Smoking is considered the chief leading cause of chronic obstructive pulmonary disease (COPD). Its impact on progressive deterioration airways has been extensively studied. However, its direct effects vasculature have not studied in deep, part due to classic conception that vascular damage a consequence alveolar hypoxia and loss capillary bed. We used different molecular cell biology approaches, as well tissue studies from vivo models human samples analyse how cigarette smoke extract (CSE)...