A5100663185- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Telomeres, Telomerase, and Senescence
- Molecular Biology Techniques and Applications
- ATP Synthase and ATPases Research
- Machine Learning in Bioinformatics
- Synthesis of Organic Compounds
- Plant biochemistry and biosynthesis
- Photosynthetic Processes and Mechanisms
- Fungal and yeast genetics research
- DNA Repair Mechanisms
- Ferroptosis and cancer prognosis
- Cardiovascular Issues in Pregnancy
- Synthesis and biological activity
- Mitochondrial Function and Pathology
- Streptococcal Infections and Treatments
- Bioinformatics and Genomic Networks
- Plant Stress Responses and Tolerance
- RNA Research and Splicing
First People's Hospital of Kunshan
2021-2025
Soochow University
2014-2025
Jiangsu University
2021-2025
Scripps MD Anderson Cancer Center
2025
Nanjing University of Chinese Medicine
2022-2024
Zhejiang A & F University
2022
Inner Mongolia Autonomous Region Meteorological Bureau
2021
Guangzhou University of Chinese Medicine
2021
Xinxiang Medical University
2020
Lunenfeld-Tanenbaum Research Institute
2017-2018
Werner Syndrome (WS) is characterized by premature aging, genomic instability, and cancer. The combined impact of WRN helicase deficiency limiting telomere reserves central to disease pathogenesis. Here, we report that cells doubly deficient for telomerase show chromosomal aberrations elevated recombination rates between telomeres sister chromatids. Somatic reconstitution function, but not a helicase-deficient mutant, abolished chromatid exchange (T-SCE), indicating normally represses...
Rice blast caused by Magnaporthe oryzae poses a major threat to rice production worldwide. The utilization of host resistance (R) genes is considered be the most effective and economic means control blast. Here, we show that japonica landrace Yangmaogu (YMG) displays broader spectrum isolates than other previously reported broad-spectrum resistant (BSR) cultivars. Genetic analysis suggested YMG contains at least three R genes. One gene, Pi64, which exhibits indica-sourced isolate CH43...
The Protection of telomeres 1 (POT1) protein is a single-stranded telomere binding that essential for proper maintenance length. Disruption POT1 function leads to chromosome instability and loss cellular viability. Here, we show targeted deletion the mouse Pot1b gene results in increased apoptosis highly proliferative tissues. In setting telomerase haploinsufficiency, depletion germ cells complete bone marrow failure due apoptosis, culminating premature death. Pot1b(-/-) mTR(+/-)...
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer‑related deaths among cancer patients. Genes correlated with progression and prognosis HCC are critically needed to be identified. In present study, 3 Gene Expression Omnibus (GEO) datasets (GSE46408, GSE65372 GSE84402) were used analyze differentially expressed genes (DEGs) between non‑tumor liver tissues. Ontology (GO) Kyoto Encyclopedia Genomes (KEGG) enrichment analyses conducted clarify functional roles DEGs. A...
Ischemia-reperfusion injury (IRI) represents a prevalent pathological phenomenon. Traditional treatment approaches primarily aim at restoring blood supply to ischemic organs, disregarding the consequent damage caused by IRI. Belonging class of protopanaxadiol ginsenosides that are found in Panax ginseng, ginsenoside Rd (GSRd) demonstrates notable safety alongside diverse range biological functions. Its active components exhibit pharmacological effects, encompassing anti-inflammatory,...
Recent studies have shown that a class of small, functional RNAs, named microRNAs, may regulate multidrug resistance-associated protein 1 (ABCC1). Since ABCC1 is an important efflux transporter responsible for cellular drug disposition, the discovery microRNAs (miRNA) brings idea there be some other unknown resistance (MDR) mechanisms exist. Using computational programs, we predicted 3′untranslated region (3′UTR) contains potential miRNA binding site miR-133a and also two miR-326. These...
Alfalfa (Medicago sativa L.) is a feed crop due to its rich nutrition and high productivity. The utilization of titanium oxide nanoparticles (TiO2 NPs) brings benefits agricultural production but also has potential hazards. To investigate the duality related mechanism TiO2 NPs on alfalfa, different doses including 0, 50, 100, 200, 500, 1000 mg L− 1 (CK, Ti-50, Ti-100, Ti-200, Ti-500, Ti-1000) were sprayed leaves. results showed that greater (500 L−1) negatively affected physiological...
Aims The Ca+/NFAT (Nuclear factor of activated T cells) signaling pathway activation is implicated in the pathogenesis Kawasaki disease (KD); however, we lack detailed information regarding regulatory network involved human coronary endothelial cell dysfunction and cardiovascular lesion development. Herein, aimed to use mouse models KD vasculitis vivo vitro characterize NFAT KD. Methods Results Among gene family, NFAT2 showed strongest transcriptional activity peripheral blood mononuclear...
The prediction model of intravenous immunoglobulin (IVIG) resistance in Kawasaki disease can calculate the probability IVIG and provide a basis for clinical decision-making. We aim to assess quality these models developed children with disease.Studies IVIG-resistant were identified through searches PubMed, Web Science, Embase databases. Two investigators independently performed literature screening, data extraction, evaluation, discrepancies settled by statistician. checklist critical...
A liver abscess caused by hypervirulent Klebsiella pneumoniae can lead to multiple invasive extrahepatic infections, including lung abscesses, endophthalmitis, brain and necrotizing fasciitis. This condition, known as invasion syndrome, progresses rapidly is associated with severe illness, high disability rates, significant mortality. However, bloodstream infections co-infection involving carbapenem-resistant Acinetobacter baumannii are exceedingly rare. The Emergency Medicine Department of...
Non-canonical roles for growth factors in the nucleus have been previously described, but their mechanism of action and biological remain enigmatic. Platelet-derived factor B (PDGFB) can drive formation low-grade glioma here we show that it localizes to human cells where binds chromatin preserve genome stability cell lineage. Failure PDGFB localize leads chromosomal abnormalities, aberrant heterochromatin architecture accelerated tumorigenesis. Furthermore, nuclear localization is reliant...
Lagerstroemia L. (Lythraceae) is a widely distributed genus of trees and shrubs native to tropical subtropical environments from Southeast Asia Australia, with numerous species highly valued as ornamentals. Although the plastomes many in this have been sequenced, rates functional gene evolution their effect on phylogenetic analyses not thoroughly examined. We compared three plastome sequence matrices elucidate how differences these datasets affected analyses. Robust relationships for were...
The development of acquired resistance to chemotherapy is a major obstacle in the successful treatment cancer. In breast cancer cells, B‑cell lymphoma‑extra large (Bcl‑xL) involved various chemotherapeutic agents; therefore, preliminary biological prediction was performed identify putative binding site for let‑7b 3'‑untranslated region (UTR) Bcl‑xL gene and single nucleotide polymorphism (SNP) within this region. present study investigated association between SNP rs3208684 A>C agent cells....
Tree peony (Paeonia suffruticosa) is a traditional Chinese flower that not resistant to high temperatures, and the frequent sunburn during summer limits its normal growth. The lack of understanding molecular mechanisms in tree has greatly restricted improvement novel heat-tolerant varieties. Therefore, we treated cultivar "Yuhong" (P. suffruticosa "Yuhong") at (25°C) temperatures (40°C) sequenced transcriptomes, investigate responsive heat stress. By comparing total 7,673 differentially...
Kawasaki disease (KD) is the most common cause of acquired heart in childhood. Coronary artery lesions (CALs) are serious complications KD that can result stenosis and thrombosis, but specific underlying pathogenic mechanisms have not been elucidated. Therefore, exploring biomarkers to help predict early CALs urgently needed for clinical treatment.
Chemotherapy is one of the most common treatments used for hepatocellular carcinoma (HCC), which effectively improves outcome and reduces tumor recurrence. However, drug resistance mechanisms involved in chemotherapy, predominant challenge HCC treatment, remain to be fully elucidated. Therefore, there an urgent requirement identification novel therapeutic strategies or drugs. MicroRNAs (miRs) have become area interest, present study, effects miR‑133a miR‑326 on HepG2 cells, their function...
B‑cell lymphoma‑extra large (Bcl‑xl) is an anti‑apoptotic member of the lymphoma 2 (Bcl‑2) family that often found to be overexpressed in human hepatocellular carcinoma (HCC), therefore conferring a survival advantage tumor cells. microRNA (miRNA) let‑7b downregulated HCC and its expression correlates with multidrug resistance. Using computational programs, it was predicted 3' untranslated region (UTR) Bcl‑xl gene contains potential miRNA binding site for let‑7b, single nucleotide...
Ilex cornuta Lindl. et Paxt. (Aquifoliaceae family) belongs to the genus. The leaves of this plant are used for popular herbal tea “Ku-Ding-Cha” in China due their health benefits sore throat, obesity and hypertension. Our previous studies have shown that extract root exerts cardioprotective effects rat models myocardial ischaemic injury, several new kinds triterpenoid saponins from (TSIC) protective against hydrogen peroxide (H2O2)-induced cardiomyocyte injury. aim study was clarify...