A5041647947- Quality and Supply Management
- Parkinson's Disease Mechanisms and Treatments
- Vehicle Routing Optimization Methods
- Optimization and Mathematical Programming
- Accounting and Organizational Management
- Scheduling and Optimization Algorithms
- Spreadsheets and End-User Computing
- Optimization and Search Problems
- Big Data and Business Intelligence
- EEG and Brain-Computer Interfaces
- Optimization and Packing Problems
- Quality and Management Systems
- Complex Systems and Decision Making
- Supply Chain and Inventory Management
- Metaheuristic Optimization Algorithms Research
- Innovation and Knowledge Management
- Reading and Literacy Development
- Pluripotent Stem Cells Research
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- AI-based Problem Solving and Planning
- Neurological disorders and treatments
- Advanced Manufacturing and Logistics Optimization
- Customer Service Quality and Loyalty
- Cognitive Science and Mapping
Research Network (United States)
2022-2025
The Francis Crick Institute
2020-2025
National Hospital for Neurology and Neurosurgery
2020-2025
University College London
2007-2025
Pepperdine University
2023
Queen Mary University of London
2020-2021
University of Cincinnati
2005-2018
Jet Propulsion Laboratory
2018
California Institute of Technology
2016
University Hospital Münster
2016
Introduction to Graphs and Networks Computer Representation Solution Tree Algorithms Shortest-Path Minimum-Cost Flow Matching Assignment The Postman Related Arc Routing Problems Traveling Salesman Vertex Location Project NETSOLVE User's Manual
The Six Sigma phenomenon has followed the TQM movement as latest thrust for many companies seeking to improve their performance and effectiveness. purpose of this paper is review basic concepts Sigma, its benefits, successful approaches implementation. In particular, we benchmark practices General Electric Company, one leaders innovators in implementing process. We conclude that keys implementation include upper management support involvement, organizational infrastructure, training, tools,...
Abstract Aggregation of alpha-synuclein (α-Syn) drives Parkinson’s disease (PD), although the initial stages self-assembly and structural conversion have not been directly observed inside neurons. In this study, we tracked intracellular conformational states α-Syn using a single-molecule Förster resonance energy transfer (smFRET) biosensor, show here that converts from monomeric state into two distinct oligomeric in neurons concentration-dependent sequence-specific manner. Three-dimensional...
ABSTRACT Background Type 2 diabetes (T2DM) is an established risk factor for developing Parkinson's disease (PD), but its effect on progression not well understood. Objective The aim of this study was to investigate the influence T2DM aspects in PD. Methods We analyzed data from Tracking examine effects comorbid PD and quality life by comparing symptom severity scores assessing a range motor nonmotor symptoms. Results identified 167 (8.7%) patients with (PD + T2DM) 1763 (91.3%) without (PD)....
A fundamental issue in the use of optimization models is tradeoff between level detail and ease using solving model. Aggregation disaggregation techniques have proven to be valuable tools for manipulating data determining appropriate policies employ this tradeoff. Furthermore, aggregation offer promise large-scale models, supply a set promising methodologies studying underlying structure both univariate multivariate sets, provide different levels decision makers. In paper, we develop general...
In 1993, Procter & Gamble (P&G) began an effort entitled strengthening global effectiveness (SGE) to streamline work processes, drive out nonvalue-added costs, and eliminate duplication. A principal component of SGE was the North American product supply study, designed reexamine reengineer P&G's product-sourcing distribution system for its operations. The methodology developed solve this problem drew on OR/MS information technology, merging integer programming, network...
Abstract The design of an effective performance measurement system, which includes the selection appropriate measures and approaches for analyzing results, is central to aligning organization’s operations with its strategic direction. Despite importance, this one area that many organizations fail address effectively. This paper reports exploratory empirical obtained from on‐line survey, on relative emphasis types measurements analysis used by in manufacturing, service, not‐for‐profit...
Corporate social responsibility has been an element of the Malcolm Baldrige Criteria for Performance Excellence since its inception in 1988. The provide a framework design and improvement high-performing organisations; as such, it implies that corporate is important factor achieving performance excellence. garnered much attention from researchers over past several decades, with most questions focusing on whether company socially responsible more likely to be financially successful. This...
The pressing need of real-world problems for quick, simple, and implementable solutions coupled with a recently increased research productivity on improved rigorously evaluated heuristic methods are rapidly increasing the need, usage, respect heuristics. This paper presents framework “optimization” by systematically examining this change in attitudes towards heuristics, their desirable features proper usage.
Abstract Background The molecular drivers of early sporadic Parkinson’s disease (PD) remain unclear, and the presence widespread end stage pathology in late masks distinction between primary or causal disease-specific events secondary consequences stressed dying cells. However, mid-stage brains (Braak stages 3 4) exhibit alpha-synuclein inclusions neuronal loss along a regional gradient severity, from unaffected-mild-moderate-severe. Here, we exploited this spatial pathological to...
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Abstract We consider an N‐period planning horizon with known demands D t ordering cost A , procurement cost, C and holding H in period t. The dynamic lot‐sizing problem is one of scheduling Q each order to meet demand minimize cost. Wagner‐Whitin algorithm for lot sizing has often been misunderstood as requiring inordinate computational time storage requirements. present efficient computer implementation the which requires low core storage, thus enabling it be potentially useful on...
Despite optimal preoxygenation, obese patients undergoing induction of general anesthesia exhibit significant hypoxemia after 2 to 4 minutes apnea. Apneic oxygenation techniques can assist airway management by extending the safe apnea time. We hypothesized that a novel method apneic via oral route would effectively prolong in an surgical population.In this open-label, parallel-arm, randomized-controlled efficacy trial, 40 ASA physical status I-II with body mass index (BMI) 30-40 were...
Abstract Mutations in the SNCA gene cause autosomal dominant Parkinson’s disease (PD), with loss of dopaminergic neurons substantia nigra, and aggregation α-synuclein. The sequence molecular events that proceed from an mutation during development, to end-stage pathology is unknown. Utilising human-induced pluripotent stem cells (hiPSCs), we resolved temporal SNCA- induced pathophysiological order discover early, likely causative, events. Our small molecule-based protocol generates highly...
The Malcolm Baldrige National Quality Award Criteria for Performance Excellence represent a framework high-performance management systems. Although the criteria have evolved based on collective wisdom of quality experts and practitioners throughout United States, little empirical research has been performed to validate its core concepts values. One key linkages in is relationship between external results internal performance metrics, which reflect processes systems that drive an...