Vascular endothelial growth factor (VEGF) plays a crucial role in physiological vasculogenesis and vascular permeability has been implicated the pathogenesis of pre‐eclampsia. Our present study was undertaken to identify associations between three functional VEGF gene polymorphisms, linked with altered responsiveness, The involved 42 pre‐eclamptic 73 healthy control women who were genotyped for –2578C/A, –634G/C 936C/T polymorphisms gene. No significant association genotypic or allelic...

We assessed serum uric acid (SUA) levels in patients with type 2 diabetes mellitus (T2DM) or without peripheral neuropathy (diagnosed by the Neuropathy Disability score [NDS]). enrolled 64 T2DM (group A: 31 men, mean age 63.0 ± 2.8 years) and 66 age-, gender-, renal function- duration-matched B: 32 62.4 3.1 years). Serum was significantly higher group A (P < .001). There a significant correlation between SUA NDS both groups r(s) = .93, P .001; r( s) .95, C-reactive protein (CRP) also .001)...

Sudomotor neuropathy is associated with reduction of plantar sweating and contributes to the pathogenesis diabetic foot ulcers. The aim present study was evaluate new indicator test for sudomotor function (Neuropad®) in diagnosis peripheral among type 2 patients. This included 104 patients (51 men) a mean age 64.2 ± 5.6 years diabetes duration 12.8 3.7 years. Peripheral diagnosed by means Diabetic Neuropathy Index (DNI). assessed colour change test. 71 (68.3 %). 67 (94.4 %) 10 (30.3 without...

Purpose . Thorough understanding of biliary anatomy is required when performing surgical interventions in the hepatobiliary system. This study describes anatomical variations right bile ducts terms branching and drainage patterns, determines their frequency. Methods We studied 73 samples cadaveric material, focusing on relationship anterior posterior segmental branches, way they form hepatic duct, main pattern. Results The duct was typical 65.75% samples. Ectopic into common found 15.07%...

We evaluated the diagnostic performance of swabs versus tissue cultures in 28 diabetic patients with neuropathic (group A) and 22 neuroischemic foot ulcer B) differences bacterial isolates between 2 groups. In group A, sensitivity, specificity, positive predictive value (PPV), negative (NPV) swab for diagnosis infection were 100%, 40%, 88.5%, respectively. B, corresponding values 22.2%, 65%, 100%. PPV, NPV identification pathogens 14.3%, 53.8%, 18.2%, 55%, each group, Staphylococcus aureus...

The aim of this study was to evaluate Achilles tendon (AT) in type 2 diabetic patients with vs. without peripheral neuropathy using Magnetic Resonance Imaging (MRI). included 19 (group A, mean age 63.9±7.4 years) and B, 63.6±6.1 neuropathy, as well 16 healthy controls C, 61.6±8.4 years). Neuropathy diagnosed by the Diabetic Index (DNI). maximum AT thickness volume were measured on sagittal T1 weighted MRI images. calculated sum surface area all contiguous sections multiplied slice thickness....

The aim of this study was to examine the potential correlation WHO-5 well-being index with glycaemic control and chronic complications in subjects type 2 diabetes. included 156 (73 men, mean age 64.05+/-9.11 years, diabetes duration 12.22+/-5.61 years). Well-being assessed by score via a validated questionnaire comprising 5 questions (Q1-Q5). HbA (1c) showed significant negative overall (r (s)=-0.248, p=0.002) individual Q1-Q4 scores (s)=-0.262, p=0.001; r p=0.002; (s)=-0.207, p=0.009...

OBJECTIVE To estimate the accuracy of Neuropad for diagnosis and staging distal symmetric polyneuropathy (DPN) across different stages neuropathy, using multiple-level likelihood ratios (LRs) to interpret time necessary complete color change test. RESEARCH DESIGN AND METHODS We conducted a cross-sectional, cohort-type diagnostic study in 251 consecutive adult type 2 diabetic patients with no peripheral arterial disease or other potential causes who were recruited between January 2005...

The aim of this study was to evaluate foot temperature in type 2 diabetic patients with vs. without peripheral neuropathy. included 30 (group A: 16 men, mean age 63.23+/-7.02 years) neuropathy and B: 17 62.37+/-6.73 Neuropathy diagnosed by the Diabetic Index (DNI). Foot measured a handheld infrared thermometer (KM 814, Kane-May, UK) on mid-dorsal aspect (dorsal temperature) plantar at level first metatarsal head (plantar temperature). Dorsal significantly higher group A than B (right...

Background and Aims: Increased foot skin temperature has been described as a feature of diabetic neuropathy. The aim this present study was to investigate the association between sudomotor dysfunction in type 2 diabetes mellitus. Patients Methods: This included 51 patients (group A: 25 men, mean age 61.14 ± 6.11 years) without 52 B: 59.54 6.18 with dysfunction. Sudomotor defined time until complete Neuropad™ color change from blue pink exceeding 600 s at least one foot. Time test also...

Aim: The aim of this prospective study was to evaluate the contribution indicator test for sudomotor function Neuropad® early diagnosis peripheral neuropathy in patients with type 2 diabetes mellitus. Included were 109 diabetic (55 men, mean age 56.15±6.14 years), whose initial clinical examination (Neuropathy Disability Score, NDS) negative neuropathy. Patients first examined between January and June 2004 re-examined 5 years later by NDS Neuropad®. Initially, 70 (64.22%) had normal 39...

Peripheral neuropathy remains a major cause of morbidity and is cardinal factor in the pathogenesis diabetic foot ulceration. The aim present study was to compare new indicator test for sudomotor function (Neuropad®) with vibration perception threshold (VPT) clinical examination diagnosis peripheral subjects type 2 diabetes. This included 154 patients (76 men) mean age 64.3±7.3 years diabetes duration 12.8±4.3 years. Neuropathy diagnosed clinically using Disability Score (NDS). VPT measured...

Alpha2B adrenoceptor (alpha2B-AR) mediates a variety of functions in humans. An insertion/deletion (I/D) polymorphism the alpha2B-AR gene located on chromosome 2 has been described. The aim present study was to investigate potential association between alpha2B I/D and peripheral neuropathy Greek patients with type diabetes mellitus. included 130 (70 men) diabetic (group A) 60 (34 without B). There no difference age, gender duration groups. Diabetic diagnosed by clinical examination using...

The aim of this paper was to assess serum uric acid (SUA) levels in patients with type 2 diabetes mellitus (T2DM) or without sudomotor dysfunction (evaluated by the Neuropad test). We included 36 T2DM (group A: mean age<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mn>63.1</mml:mn><mml:mo>±</mml:mo><mml:mn>2.6</mml:mn></mml:mrow></mml:math>years) and 40 age-, gender-, renal function- duration-matched B:...

Introduction: There is increased evidence that circulating levels of matrix metalloproteinases and their tissue inhibitors are altered in obesity may be implicated its pathogenesis. This study aimed to compare the serum concentrations pro-matrix metalloproteinase-1 (pro-MMP-1) inhibitor metalloproteinases-1 (TIMP-1) severely obese patients with or without metabolic syndrome, investigate potential effect weight loss on levels.

Uncoupling proteins are attractive candidate genes for obesity and type 2 diabetes mellitus. Our aim was to investigate the potential association of uncoupling protein-2 (UCP2) 45-bp insertion/deletion (ins/del) polymorphism with obesity, as well effect this on weight loss variability in severely obese subjects.A total 158 subjects (94 without 64 metabolic syndrome) 91 age sex-matched lean controls were recruited. A subgroup 124 patients participated a 3-month program. Anthropometric...

The aim of this study was to examine the reproducibility new indicator test for sudomotor function (Neuropad) in type 2 diabetic patients. included 142 patients (70 men) with a mean age 67.3 +/- 7.6 years and diabetes duration 14.2 6.3 years. Sudomotor assessed by means colour change test. Each patient examined twice. Moreover, inter-observer variability 60 (35 dysfunction, 25 without dysfunction). In right foot, highly significant (r = 0.91, p 0.001) correlation observed between time until...