A5100385768- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Cancer-related gene regulation
- PI3K/AKT/mTOR signaling in cancer
- CRISPR and Genetic Engineering
- Tissue Engineering and Regenerative Medicine
- RNA and protein synthesis mechanisms
- Tuberous Sclerosis Complex Research
- Pregnancy and Medication Impact
- Epigenetics and DNA Methylation
- Microbial Metabolic Engineering and Bioproduction
- Cellular Mechanics and Interactions
- Electrospun Nanofibers in Biomedical Applications
- Neonatal Respiratory Health Research
- Enzyme Structure and Function
- Cancer, Hypoxia, and Metabolism
- Mast cells and histamine
- RNA modifications and cancer
- Arsenic contamination and mitigation
- Fluoride Effects and Removal
- Ferroptosis and cancer prognosis
- Microbial Metabolism and Applications
- Photosynthetic Processes and Mechanisms
Fudan University
2024
Anhui Medical University
2021-2024
Institute of Food Science and Technology
2022
Chinese Academy of Agricultural Sciences
2022
First Affiliated Hospital of Anhui Medical University
2021
Sun Yat-sen University
2017
State Key Laboratory of Pollution Control and Resource Reuse
2013
Nanjing University
2013
The dysregulated mechanistic target of rapamycin complex 1 (mTORC1) signaling plays a critical role in ferroptosis resistance and tumorigenesis. However, the precise underlying mechanisms still need to be fully understood. Endoplasmic reticulum oxidoreductase alpha (ERO1α) expression mTORC1-activated mouse embryonic fibroblasts, cancer cells, laryngeal squamous cell carcinoma (LSCC) clinical samples was examined by quantitative real-time PCR (qRT-PCR), western blotting, immunofluorescence...
Abstract As evidenced by the behavior of loss-of-function mutants PTEN in context a gain-of-function mutation AKT1, PTEN-AKT1 signaling pathway plays critical role human cancers. In this study, we demonstrated that deficiency or activation AKT1 potentiated expression platelet-derived growth factor receptor α (PDGFRα) based on studies Pten−/− mouse embryonic fibroblasts, cancer cell lines, hepatic tissues Pten conditional knockout mice, and tissues. Loss enhanced PDGFRα via AKT1-CREB cascade....
Angiogenesis is a key characteristic of asthma airway remodeling. By releasing cationic granule proteins, such as major basic protein (MBP), activated eosinophils play prominent role in asthma, but the underlying mechanisms are still not fully understood. In this study, we demonstrated that fibroblast growth factor-binding 1 (FGFBP1) was dramatically upregulated epithelial cell lines treated by poly-L-arginine (PLA), mimic MBP. Elevated FGFBP1 expression also detected clinical samples, well...
Scope Fibroblast growth factor 21 (FGF21) participated in fish oil-mediated hepatic lipid-regulation and anti-inflammatory effects high-fat diet fed-mice. However, oil supplementation did not significantly increase FGF21 protein levels. Whether oil-induced benefits the liver are related to sensitivity remains unclear. Methods results Male C57BL/6J mice were fed a low-fat (LFD), (HFD) or oil-supplemented (FOD) for 12 weeks. Fish improved HFD-induced steatosis inflammation, while it exerted no...
Loss of function tuberous sclerosis complex 1 or 2 (TSC1 TSC2) leads to the activation mammalian target rapamycin (mTORC1). Hyperactivated mTORC1 plays a critical role in tumor growth, but underlying mechanism is still not completely elucidated. Here, by analyzing Tsc1- Tsc2-null mouse embryonic fibroblasts, rat ELT3 cells, and human cancer we present evidence for involvement epidermal growth factor receptor (EGFR) as downstream growth. We show that increased EGFR expression through...
The CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated proteins) system is an efficient and precise gene editing tool. development of this technology has promoted genome into a rapid stage. most widely used Cas9 protein SpyCas9 from Streptococcus pyogenes. As "gene scissors", the in eukaryotes including mammals plants. However, application some lactic acid bacteria (LAB) still hampered by many factors. It been identified that LAB genomes possess types...