A5030813083- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Viral Infections and Immunology Research
- Zebrafish Biomedical Research Applications
- Fish Ecology and Management Studies
- Drug Transport and Resistance Mechanisms
- Adenosine and Purinergic Signaling
- Organ Transplantation Techniques and Outcomes
- Nematode management and characterization studies
- Reproductive Health and Contraception
- Animal Behavior and Reproduction
- Metabolism and Genetic Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Hormonal Regulation and Hypertension
- Pharmacogenetics and Drug Metabolism
- Banana Cultivation and Research
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Neuroendocrine regulation and behavior
- Climate Change and Health Impacts
- Ovarian function and disorders
- Mechanical Circulatory Support Devices
- Pharmacology and Obesity Treatment
- Pharmacological Effects and Toxicity Studies
- HIV/AIDS drug development and treatment
PAX Scientific (United States)
2024
University of Colorado Anschutz Medical Campus
2016-2020
University of Colorado Denver
2017-2020
Community Link
2019
University of Montana
2016-2018
University of Idaho
2016
BackgroundMolecular testing with gene expression profiling (GEP) and donor-derived cell-free DNA (dd-cfDNA) is increasingly used in the surveillance for acute cellular rejection (ACR) after heart transplant. However, performance of dual over each test individually has not been established. Further, impact non-invasive on clinical decision-making widely investigated.MethodsWe evaluated 2077 subjects from SHORE registry who were enrolled between 2018 2021 had verified biopsy data, categorized...
Zebrafish (Danio rerio) have emerged as a popular model for studying the pharmacology and behavior of anxiety. While there been numerous studies documenting anxiolytic anxiogenic effects common drugs in zebrafish, many do not report or test behavioral differences between sexes. Previous indicated that males females differ their baseline level In this study, we sex interaction with fluoxetine nicotine. We exposed fish to system water (control), 10 mg/L fluoxetine, 1 nicotine three minutes...
To identify genetic variants that influence steady-state etonogestrel concentrations among contraceptive implant users.We enrolled healthy, reproductive-age women in our pharmacogenomic study using implants for 12-36 months without concomitant use of hepatic enzyme inducers or inhibitors. We collected participant characteristics, measured serum concentrations, and genotyped each 120 single nucleotide 14 genes encoding proteins involved steroid hormone (ie, estrogens, progestins) metabolism,...
To evaluate factors influencing cardiologists' perspectives about pharmacogenomic (PGx) testing in clinical practice.Semistructured interviews with practicing cardiologists were qualitatively analyzed to identify common themes.Five themes identified among 16 from four specialties (n = 5 general cardiology, n 3 electrophysiology, 2 adult congenital and 6 heart failure/transplant): knowledge needs, perceived validity utility of PGx testing, dissemination management results, patient-related...
Zebrafish (Danio rerio) have emerged as a popular model for studying pharmacological effects on behavior and anxiety. While there been numerous studies documenting the anxiolytic anxiogenic of common drugs in zebrafish, many do not report or test behavioral differences between sexes. Previous zebrafish indicated that males females differ their responses to In this study, we sex-dependent fluoxetine nicotine. We exposed fish system water (control), 10 mg/L fluoxetine, 1 nicotine three minutes...
Background: The goal of the study was to assess relationship between single nucleotide variants (SNVs) in calcineurin inhibitor (CNI) pharmacokinetic and pharmacodynamic genes renal dysfunction adult heart transplant (HTx) recipients. Methods: This retrospective analysis included N = 192 patients receiving a CNI at 1-year post-HTx. Using candidate gene approach, 93 SNVs eight 35 were chosen for investigation. primary outcome after HTx, defined as an estimated glomerular filtration rate...
Zebrafish (Danio rerio) have emerged as a popular model for studying pharmacological effects on behavior and anxiety. While there been numerous studies documenting the anxiolytic anxiogenic of common drugs in zebrafish, many do not report or test behavioral differences between sexes. Previous zebrafish indicated that males females differ their responses to In this study, we sex-dependent fluoxetine nicotine. We exposed fish system water (control), 10 mg/L fluoxetine, 1 nicotine three minutes...
Zebrafish ( Danio rerio ) have emerged as a popular model for studying the pharmacology and behavior of anxiety. While there been numerous studies documenting anxiolytic anxiogenic effects common drugs in zebrafish, many do not report or test behavioral differences between sexes. Previous indicated that males females differ their baseline level In this study, we sex interaction with fluoxetine nicotine. We exposed fish to system water (control), 10 mg/L fluoxetine, 1 nicotine three minutes...
Zebrafish (Danio rerio) have emerged as a popular model for studying pharmacological effects on behavior and anxiety. While there been numerous studies documenting the anxiolytic anxiogenic of common drugs in zebrafish, many do not report or test behavioral differences between sexes. Previous zebrafish indicated that males females differ their responses to In this study, we sex-dependent fluoxetine nicotine. We exposed fish system water (control), 10 mg/L fluoxetine, 1 nicotine three minutes...
OBJECTIVES/SPECIFIC AIMS: Heart transplant (HTx) recipients are more likely to exhibit abnormal circadian blood pressure (BP) patterns (e.g., lack of nocturnal dip in BP) compared with the general population. Our goal was assess relationship between BP and end-organ damage HTx recipients. METHODS/STUDY POPULATION: The retrospective study included 30 patients who were ≥ 6 months post-heart had 24-hour ambulatory data collected during a parent study. Nocturnal decline categorized as: ≥10%...
Abstract Background We assessed the relationship between circadian blood pressure (BP) patterns and clinical outcomes in a contemporary cohort of adult heart transplant recipients. Methods This retrospective, cross‐sectional study included recipients at least 6 months post‐transplant. Ambulatory BP measurements were recorded over 24 hours. Nondippers defined as decline average nighttime ≤ 10% compared with daytime. Primary presence end organ damage, that is, microalbuminuria, chronic kidney...