Bullous pemphigoid (BP) is an inflammatory subepidermal blistering disease associated with IgG autoimmune response to the hemidesmosomal protein, BP180. Using a passive transfer mouse model, our group has shown previously that antibodies murine BP180 (mBP180) ectodomain are capable of triggering skin closely mimics human BP. In this study, we investigated role neutrophils in immunopathogenesis model. BALB/c mice depleted circulating by treatment neutrophil-specific were no longer susceptible...

The first example of rare earth metal-catalyzed cycloaddition terminal alkynes to azides resulting in the formation 1,5-disubstituted 1,2,3-triazoles is described. Preliminary studies revealed that present shows unprecedented mechanistic features involving a tandem anionic cascade cyclization and anti-addition across CC triple bond.

A mild, versatile, and efficient method for the one-step synthesis of substituted dihydro- tetrahydroisoquinolines has been developed by FeCl3·6H2O catalyzed intramolecular allenylation/cyclization reaction benzylamino-substituted propargylic alcohols, representing first example Friedel−Crafts alcohols.

Iron chloride has been found to be an efficient catalyst for the disproportionation of allylic alcohols, which provides a convenient method selective transformation alcohols alkenes and α,β-unsaturated ketones. Furthermore, this catalytic system is also effective highly reduction ethers, acetates with benzyl alcohol under neutral reaction conditions.

Abstract Two new trinuclear μ 3 ‐bridged rare‐earth metal phosphinidene complexes, [{L(Ln)(μ‐Me)} (μ ‐Me)(μ ‐PPh)] (L=[PhC(NC 6 H 4 i Pr 2 ‐2,6) ] − , Ln=Y ( a ), Lu b )), were synthesized through methane elimination of the corresponding carbene precursors with phenylphosphine. Heating toluene solution at 120 °C leads to an unprecedented ortho CH bond activation PhP ligand form bridged phosphinidene/phenyl complexes. Reactions ketones, thione, or isothiocyanate show clear phospha‐Wittig...

The reaction of (C5H5)YCl2(THF)3 with LiNiPr2 and subsequently 2 equiv N,N'-diisopropylcarbodiimide (iPrNCNiPr) in THF gave the organoyttrium guanidinates Y[iPrNC(NiPr2)NiPr]3 (1) (C5H5)2Y[iPrNC(NiPr2)NiPr] (2), which may be rationalized by rearrangement diinsertion product (C5H5)Y[iPrNC(NiPr2)NiPr]2. Treatment iPrNCNiPr lanthanocene primary amides [(C5H5)2LnNHR]2 (R = tBu, Ln Yb, Er, Dy, Y; R Ph, Yb) unexpected products (C5H5)2Yb[RNC(NHiPr)NiPr] Yb (3), Er (4), Dy (5), Y(6); (7)),...

The treatment of [(Me(3)Si)(2)NC(NCy)(2)](2)Ln(mu-Cl)(2)Li(THF)(2) with 1 equiv BnK (Bn = benzyl) in toluene affords [(Me(3)Si)(2)NC(NCy)(2)](2)LnBn [Ln Er (1-Er), Y (1-Y)] good yields. Similarly, [(Me(3)Si)(2)NC(NCy)(2)](2)Ln(t)Bu (2-Er), Yb (2-Yb)] are obtained satisfactory yields by the reaction (t)BuLi hexane. reacts 1/8 S(8) to form sulfur insertion products {[(Me(3)Si)(2)NC(NCy)(2)](2)Ln(mu-SBn)}(2) (3-Er), (3-Y)], while 2 elemental under same conditions oxidation...

The synthesis, structure, and reactivity of organoyttrium phosphides toward phenyl isocyanate (PhNCO) isothiocyanate (PhNCS) are described. Reaction (TpMe2)CpYCH2Ph(THF) (TpMe2 = tris(3,5-dimethylpyrazolyl)borate; Cp C5H5) with 1 equiv HPPh2 in THF at ambient temperature gives an phosphide (TpMe2)CpYPPh2(THF) (1). Treatment PhNCO results monoinsertion into the Y–P σ-bond to yield complex (TpMe2)CpY[OC(PPh2)NPh](THF) (2), whereas reaction 2 affords diinsertion product...

Three kinds of solvated lithium amidinates with different coordination models were obtained via recrystallization [PhC(NC6H4iPr2-2,6)2]Li(THF) (1a) in solvents. Treatment o-Me2NC6H4CH2Li LLnCl2(THF)n (2; L = [PhC(NC6H4iPr2-2,6)2]− (NCNdipp), [o-Me2NC6H4CH2C(NC6H4iPr2-2,6)2]− (NCNdipp′)) formed situ from reaction LnCl3(THF)x LLi(THF) gave the rare-earth-metal bis(aminobenzyl) complexes LLn(CH2C6H4NMe2-o)2 (L NCNdipp, Ln Sc (3a), Y (3b), Lu (3c); NCNdipp′, (3d), (3e)) high yields. Reactions 3...

Mononuclear amidinate yttrium complex C4 H9 C(NR)2 Y(o-CH2 C6 H4 NMe2 )2 (R=2,6-iPr2 H3 ) and a series of binuclear rare-earth metal complexes bearing bridged ligand [(RN)2 C(CH2 )4 ][RE{CH2 (o-NMe2 )}2 ]2 , RE=Y, Lu, Sc) were synthesized fully characterized. The catalytic behavior these for (co)polymerization conjugated dienes such as isoprene myrcene in the presence co-catalyst [Ph3 C][B(C6 F5 ] was investigated. These systems show impressively high activity 3,4-regioselectivity living...

The alkylidene transfer reactions of alkenes are particular significance but challenging. Here, we report that enones can serve as diverse sources for catalyst-controlled selective C-H alkylation and/or alkylidenation various nucleophiles. Treatment a mixture ketone (or lactam), enone and diarylmethanol with catalytic amount Y[N(TMS)2]3, gave the corresponding α-C-H bond products derived from to ketones/lactams, whereas reaction C-nucleophiles in presence KOH catalyst resulted...

The alkylidene transfer reactions of alkenes are particular significance but challenging. Here, we report that enones can serve as diverse sources for catalyst‐controlled selective C–H alkylation and/or alkylidenation various nucleophiles. Treatment a mixture ketone (or lactam), enone and diarylmethanol with catalytic amount Y[N(TMS)2]3, gave the corresponding α‐C–H bond products derived from to ketones/lactams, whereas reaction C‐nucleophiles in presence KOH catalyst resulted...

A novel, convenient, and efficient method has been developed for selective synthesis of spirocycle, polycycle, di- tetrahydronaphthalene systems from aryl-substituted propargylic alcohols by FeCl3- or TsOH-catalyzed multiple activations unsaturated C−C bonds C−H bonds.

The structurally characterized Tp(Me2)-supported rare earth metal monoalkyl complex (Tp(Me2))CpYCH(2)Ph(THF) (1) was synthesized via the salt-metathesis reaction of (Tp(Me2))CpYCl(THF) with KCH(2)Ph in THF at room temperature. Treatment 1 equiv PhC≡CH under same conditions afforded corresponding alkynyl (Tp(Me2))CpYC≡CPh(THF) (2). Complex exhibits high activity toward carbodiimides, isocyanate, isothiocyanate, and CS(2); treatment such substrates led to formation a series Y-C(benzyl) σ-bond...

Abstract A convenient and efficient method for the synthesis of polysubstituted indenes has been developed by iron(III) trichloride‐catalyzed tandem mono‐ dibenzylation/cyclization reactions benzylic alcohols with alkynes. This is featured easily available starting materials, cheap catalyst, simple manipulation mild conditions.

A lanthanide-catalyzed sequential insertion of CN and CC into an NH bond is presented. The convenient reaction, which proceeds under mild conditions, efficient method for preparing 1,2,4-trisubstituted imidazoles directly from readily available propargylamines nitriles.

Lanthanide-catalyzed alkynyl exchange through C-C single-bond cleavage assisted by a secondary amino group is reported. A lanthanide amido complex proposed as key intermediate, which undergoes unprecedented reversible β-alkynyl elimination followed and imine reinsertion. The in situ homo- cross-dimerization of the liberated alkyne can serve an additional driving force to shift metathesis equilibrium completion. This reaction formally complementary conventional allows selective transformation...

The rare-earth-metal organic cyclo-P4 complex (LY·DMAP)2[1,2-R2-cyclo-P4] (2, L = N,N′-2,6-diisopropylphenyl-1,4-diazabutadiene, DMAP 4-N,N′-dimethylpyridine, R CH2C6H4NMe2-2) was synthesized by direct functionalization of P4 using the alkyl LYR(THF) (1) for first time. Further investigations indicated that three selective conversions species have been realized migration. Complex 2 slowly transformed into a R2P-substituted cyclo-P3 cluster (LY·DMAP)2[cyclo-P3PR2] (3) under heating...