A5045322296- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Polymer Surface Interaction Studies
- Synthesis and characterization of novel inorganic/organometallic compounds
- Advanced biosensing and bioanalysis techniques
- Advanced Biosensing Techniques and Applications
- Organometallic Complex Synthesis and Catalysis
- Biosensors and Analytical Detection
- Organophosphorus compounds synthesis
- Marine Biology and Environmental Chemistry
- Block Copolymer Self-Assembly
- Blood properties and coagulation
- Coordination Chemistry and Organometallics
- Advanced Polymer Synthesis and Characterization
- Force Microscopy Techniques and Applications
- Surface Modification and Superhydrophobicity
- Crystallography and molecular interactions
- Organoboron and organosilicon chemistry
Czech Academy of Sciences, Institute of Macromolecular Chemistry
2024-2025
G.A. Razuvaev Institute of Organometallic Chemistry
2018-2020
The analysis of low-abundance protein molecules in human serum is reported based on counting the individual affinity-captured analyte a solid sensor surface, yielding readout format similar to digital assays. In this approach, sandwich immunoassay with rolling circle amplification (RCA) used for single molecule detection (SMD) through associating target spatially distinct bright spots observed by fluorescence microscopy. unspecific interaction and other constituents surface particular...
Abstract The wetting of diblock copolymer brushes by water is studied. Th goal this work to understand how the thickness bottom and top block affect behavior, respectively. For synthesis block, a hydrophilic poly(2‐hydroxyethyl methacrylate) (PHEMA) brush grafted from undecyl‐trichloro‐self‐ assembled monolayer on silicon wafer. Then hydrophobic polystyrene (PS) or poly(2‐ethylhexyl (PEtHexMA) PHEMA block. Hereby, hydrophilic‐ b ‐hydrophobic obtained. determines advancing contact angle in...
The current study provides a clear understanding of the chemical properties annelated 3a,6a-diaza-1,4-diphosphapentalenes (DDPs), which are best viewed as stabilized singlet phosphinidenes. It was found that DDPs undergo reversible oligomerization in solution, 1,2,3-diazaphosphole-substituted cyclotetraphosphines, isolated and characterized by X-ray crystal structure analysis. Transformation 10-π-electron heteropentalene system into phosphinidene occurs when P–N bond is lengthened,...
Abstract Prevention of fouling from proteins in blood plasma attracts significant efforts, and great progress is made identifying surface coatings that display antifouling properties. In particular, poly(ethylene glycol) (PEG) widely used dense PEG‐like cylindrical brushes poly[oligo(ethylene methacrylate] (poly(OEGMA)) can drastically reduce fouling. Herein, a comprehensive study the variation on this surface, including analysis composition protein deposits poly(OEGMA) after contact with...
Herein, we present the synthesis, single-crystal X-ray structures, and spectroscopic properties for 1:1 donor–acceptor complexes of 1,2,4,5-tetracyanobenzene (TCNB) with annelated 3a,6a-diaza-1,4-diphosphapentalenes (DDPs) based on cyclohexanone azine (2) tetralone (4). These are first an organic π-acceptor donor phosphorus heterocycles. According to study, DDPs TCNB molecules alternately stacked interplanar distances 3.335 3.404 Å 2 4, respectively, which suitable intermolecular π···π...
The immuno-rolling circle amplification assay is demonstrated for the detection of cancer biomarkers in serum samples with high sensitivity. Real-time imaging single molecules possible surface plasmon-enhanced fluorescence.