A5014499455- Genomics, phytochemicals, and oxidative stress
- Fish Ecology and Management Studies
- Reproductive biology and impacts on aquatic species
- Identification and Quantification in Food
- CRISPR and Genetic Engineering
- Animal Behavior and Reproduction
- Glutathione Transferases and Polymorphisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Wnt/β-catenin signaling in development and cancer
- Ubiquitin and proteasome pathways
- Conservation, Biodiversity, and Resource Management
- Adhesion, Friction, and Surface Interactions
- Economic and Environmental Valuation
- Animal Behavior and Welfare Studies
- CAR-T cell therapy research
- Aquaculture Nutrition and Growth
- Cancer-related gene regulation
- Coenzyme Q10 studies and effects
- Liver Disease Diagnosis and Treatment
- Plant and animal studies
- Melanoma and MAPK Pathways
- Cancer Genomics and Diagnostics
- Autophagy in Disease and Therapy
- Nitrogen and Sulfur Effects on Brassica
- Endoplasmic Reticulum Stress and Disease
American Bird Conservancy
2024
University of Dundee
2015-2022
Wellcome Sanger Institute
2020-2022
Toi Ohomai Institute of Technology
2021-2022
Ninewells Hospital
2015-2022
Western Laboratories (United States)
1993
Core Laboratories (United States)
1993
Massey University
1980
Abstract Genetic redundancy has evolved as a way for human cells to survive the loss of genes that are single copy and essential in other organisms, but also allows tumours despite having highly rearranged genomes. In this study we CRISPR screen 1191 gene pairs, including paralogues known predicted synthetic lethal interactions identify 105 combinations whose co-disruption results cellular fitness. 27 pairs influence fitness across multiple cell lines FAM50A/FAM50B , two unknown function....
Targeting the MAPK signaling pathway has transformed treatment of metastatic melanoma. CRISPR-Cas9 genetic screens provide a genome-wide approach to uncover novel dependencies that might serve as therapeutic targets. Here, we analyzed recently reported comparing data from 28 melanoma cell lines and 313 other tumor types in order identify fitness genes related We found an average 1,494 each line. identified 33 genes, inactivation which specifically reduced This set type-specific includes...
The stunning sexual transformation commonly triggered by age, size or social context in some fishes is one of the best examples phenotypic plasticity thus far described. To date our understanding this process dominated studies on a handful subtropical and tropical teleosts, often wild settings. Here we have established protogynous New Zealand spotty wrasse, Notolabrus celidotus, as temperate model for experimental investigation sex change. Captive fish were induced to change using aromatase...
Abstract Despite decades of conservation effort, Caribbean endemic and threatened bird species continue to decline many are Critically Endangered. In 2022, the BirdsCaribbean Endemic Threatened Species Working Group (ETSWG) conducted a survey organization’s membership assess avian priorities current capacity for action in Caribbean. Drought, climate change, fire, hurricanes, pollution were perceived as key threats species, while lack data on or habitat, poor access information, collaboration...
Sex change occurs as a usual part of the life cycle for many teleost fish and modifications involved (behavioural, gonadal, morphological) are well studied. However, mechanism that transduces environmental cues into molecular cascade underlies this transformation remains unknown. Cortisol, main stress hormone in fish, is hypothesised to be key factor linking stimuli with sex by initiating gene expression changes shift steroidogenesis from oestrogens androgens but notion rigorously tested....
Aim(s): This systematic review aims to provide an overview of evidence regarding the link between offending and mental health difficulties, before focusing upon young people’s (YP’s), parents’ professionals’ experiences provision. Method/Rationale: Within literature there is a wealth quantitative research focused needs offenders (YOs); however, less weighting given individuals’ perspectives. Consequently, this paper explore how provision experienced by those in system. Four databases were...
The selection of carrion by Australasian harriers was studied offering a choice baits in the field. These trials tested preferences for species, amount flesh exposed, body posture, and colour carrion. Domestic hen pullets Norway rats were chosen significantly more often than rabbits, opossums, or eels. Skinned rabbits preferred to unskinned ones. Body posture rabbit carcasses did not appear affect harrier's choice. White blue red, brown, green baits. most important factors involved be ease...