A5084873420- Gut microbiota and health
- Spaceflight effects on biology
- Health, psychology, and well-being
- Tryptophan and brain disorders
- Digital Mental Health Interventions
- Diet and metabolism studies
- Stress Responses and Cortisol
- Clostridium difficile and Clostridium perfringens research
- Electrochemical sensors and biosensors
- Microbial Fuel Cells and Bioremediation
- Probiotics and Fermented Foods
- Advanced biosensing and bioanalysis techniques
- Medical and Biological Ozone Research
- Salivary Gland Disorders and Functions
- Circadian rhythm and melatonin
- Neuroendocrine regulation and behavior
- Health and Wellbeing Research
- Grit, Self-Efficacy, and Motivation
- Plant biochemistry and biosynthesis
- Biosensors and Analytical Detection
- Gastrointestinal motility and disorders
- Electrochemical Analysis and Applications
- Indoor Air Quality and Microbial Exposure
- Space Exploration and Technology
- Oral microbiology and periodontitis research
Beijing Institute of Technology
2022-2025
Ministry of Industry and Information Technology
2022-2025
Beihang University
2018-2023
Beijing Advanced Sciences and Innovation Center
2018-2022
University of Ottawa
2020
Psychological health risk is one of the most severe and complex risks in manned deep-space exploration long-term closed environments. Recently, with in-depth research microbiota-gut-brain axis, gut microbiota has been considered a new approach to maintain improve psychological health. However, correlation between changes inside environments still poorly understood. Herein, we used "Lunar Palace 365" mission, 1-year-long isolation study Lunar 1 (a Bioregenerative Life Support System facility...
Increasing evidences indicate that gut microbiota composition is associated with multiple inflammatory diseases. However, little known about how changes age and correlations inflammation at sexual maturity stage of healthy individuals. Elucidating the dynamic in individuals can provide clues for early risk assessment diseases stage. Here, shift bacteria its relationship were explored. Sprague–Dawley rats used this study. 16S rRNA gene sequencing was performed to decipher shifts from 7th week...
Summary Understanding the dynamics of human gut microbiota in space is crucial maintaining astronaut health. Long‐duration and deep‐space manned exploration will require situ regeneration resources, which would be achieved by an artificial ecosystem, such as a bioregenerative life‐support system (BLSS). Potential response to particular lifestyle dietary structure experienced BLSS remains unclear. Here, we report how impacts during 105‐day study that took place Chinese Lunar Palace 1 (LP1)....
Subhealth is a condition between health and disease that has become common public risk. Therefore, it necessary to find more scientific therapies can alleviate the symptoms of subhealth effectively. The gut microbiota closely associated with subhealth. As mature probiotic preparation, Bacillus licheniformis (B. licheniformis) regulate balance, which indicates B. potential in regulating This study produced subhealthy rats by using chronic stress for 4 weeks simulate psychological stress,...
Abstract Psychobiotics are a distinct category of probiotics known for their beneficial effects on human health, particularly in influencing mental well‐being. Typical psychobiotics include genera such as Lactobacillus , Streptococcus and Bifidobacterium . The gut microbiota influences bidirectional communication between the brain gastrointestinal (GI) system. Neurons enteric nervous system directly interact with neurotransmitters, short‐chain fatty acids (SCFAs), hormones, anti‐inflammatory...
A cobalt metal-organic framework (Co MOF)-ionic liquid (IL) nanocomposite comprising the base matrix of electrode was developed with electropolymerized molecularly imprinted polymer (MIP) consisting o-phenylenediamine (oPD) to detect carcinoembryonic antigen (CEA), a biomarker breast cancer. Firstly, Co MOF synthesized using hydrothermal synthesis, which used as an electrically conductive skeleton and functionalized IL. Then, CEA employed template in electropolymerization oPD-imprinted films...
The gut microbiome shows individual specificity and is affected by sex, environment, diet; imbalance related to cancer, cardiovascular diseases, autoimmune diseases. Astronauts are faced with a challenging environment limited diet in outer space. Recent studies indicate that the altered space simulators space, but what happens intestinal microorganisms when astronauts cohabitate self-sufficient ecosystem which they plant cook food unclear. Bioregenerative life support systems (BLSSs) ideal...
The long-term exposure to enclosed environments may lead chronic stress in crewmembers and affect their physical mental state. Salivary microbiome biomarkers of immune function are increasingly used human health research. "Lunar Palace 365" project, which was a 370-day, multicrew, experiment carried out ground-based bioregenerative life support system platform named Lunar 1 (LP1). We investigated the temporal dynamics salivary microbiota cytokines third phase experiment, including month...
Metaproteomics has been used in combination with vitro gut microbiota models to study drug–microbiome interactions. However, it remains unexplored whether the metaproteomics profile of responds differently a same stimulus added at different growth phases. In this study, we cultured human 96-deep well plates using previously validated model. Metformin was during lag, log, and stationary Microbiome samples, collected time points, were analyzed by optical density function metaproteomic. The...
Abstract Background Chinese Lunar Palace 1 (LP1) is a ground-based bio-regenerative life support system (BLSS) test bed integrating highly efficient plant cultivation, animal protein production, urine nitrogen recycling, and bioconversion of solid waste. To date, there has been no molecular method-based detailed investigation the fungal community mycotoxin potential in BLSS habitats. ensure safe design for actual space missions, we analyzed LP1 surface mycobiome during 365 project through...
Toxicity determination based on electrochemically active bacteria (EAB) shows great prospects for early warning of water pollution. However, the lifetime and reusability EAB in toxicity remain uncertain. This study performed continuous by using an automatic system EAB. Results demonstrated that are capable rapid responses to common heavy metal pollutants make a full recovery after refreshment. Despite changes microbial communities, maintain similar current generation capacity sensitivity...
Abstract Compared with the normal environment, microbiota in controlled closed cabins such as space capsules, Lunar/Mars bases have changed. To ensure health of crewmembers, it’s necessary to understand effects these changes on human symbiotic microorganisms and immunity. In this study, experimental platform “Lunar Palace 1” a similar environment was used research changed microbial exposure saliva salivary cytokines. This paper studied four crewmembers who participated third phase 365”...
Electrochemically active bacteria (EAB) serve as the catalyst for microbial electrochemical systems, enabling simultaneous wastewater treatment and electricity generation. However, increasing presence of toxic pollutants in may inhibit EAB metabolism decrease abundance, detailed effects adaptability remain unclear. The study used two to simulate long-term incremental exposure. study's results show that current generation is significantly inhibited at early stage exposure, but inhibition...
Correction for ‘Effects of long-term and incremental exposure to toxic pollutants on the current generation microbial communities electrochemically active bacteria’ by Yue Yi et al. , Environ. Sci.: Water Res. Technol. 2024, https://doi.org/10.1039/D3EW00522D.