A5015884132- Neurological Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Acute Ischemic Stroke Management
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Medical Imaging Techniques and Applications
- Mental Health Research Topics
- RNA regulation and disease
- Cerebrovascular and Carotid Artery Diseases
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- MRI in cancer diagnosis
- Memory and Neural Mechanisms
- Nuclear Receptors and Signaling
- Radiopharmaceutical Chemistry and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Anatomy and Medical Technology
- Medical Imaging and Analysis
- Chemical Reactions and Isotopes
- Mass Spectrometry Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiation Therapy and Dosimetry
- Atomic and Subatomic Physics Research
University of Pittsburgh
2021-2024
University of Wisconsin–Madison
2019-2020
University of Maryland, Baltimore
2020
White matter hyperintensity (WMH) lesions on brain MRI images are surrogate markers of cerebral small vessel disease. Longitudinal studies examining the association between diabetes and WMH progression have yielded mixed results. Thus, in this study, we investigated HbA1c, a biomarker for presence severity hyperglycemia, longitudinal change after adjusting known risk factors progression. We recruited 64 participants from South Korean memory clinics to undergo at baseline 2-year follow-up....
Background: Altered glymphatic-related fluid dynamics are increasingly recognized as a key feature of Alzheimers disease (AD). We generalized an established diffusion imaging technique to estimate periventricular diffusivity (PVeD), hypothesizing that fast signals in the region can reflect amyloid-beta deposition across AD continuum. Methods: Participants from two multi-site cohorts (n = 440 and 414), comprising cognitively unimpaired individuals, those with mild cognitive impairment,...
Abstract INTRODUCTION Compared to males, females have an accelerated trajectory of cognitive decline in Alzheimer's disease (AD). The neurobiological factors underlying the more rapid AD remain unclear. This study explored how sex‐dependent alterations hippocampal connectivity over 2 years are associated with cerebrovascular and amyloid pathologies normal aging. METHODS Thirty‐three 21 males 65 93 age no impairment performed a face‐name associative memory functional magnetic resonance...
<p dir="ltr">White matter hyperintensity (WMH) lesions on brain MRI images are surrogate markers of cerebral small vessel disease (CSVD). Longitudinal studies examining the association between diabetes and WMH progression have yielded mixed results. Thus, in this study we investigated HbA1c, a biomarker for presence severity hyperglycemia, longitudinal change after adjusting known risk factors progression. We recruited 64 participants from South Korean memory clinics to undergo at...
White matter hyperintensities (WMH) on brain MRI images are the most common feature of cerebral small vessel disease (CSVD). Studies have yielded divergent findings modifiable risk factors for WMH and WMH's impact cognitive decline. Mounting evidence suggests sex differences in burden subsequent effects cognition. Thus, we aimed to identify sex-specific WMH. We then explored whether there were associations longitudinal clinical dementia outcomes.
Purpose Pelvic target dose from intensity-modulated proton therapy (IMPT) is sensitive to patient bowel motion. Robustly optimized plans in regard filling may improve the coverage treatment course. Our purpose investigate effect of air volume large and small rectum on IMPT plans.Methods material Data 17 cancer patients (11 prostate, 3 gynecologic, 2 colon, 1 embryonal rhabdomyosarcoma) with planning CT (pCT) weekly or biweekly scanned quality assurance CTs (QACTs; 82 QACT scans total) were...
Traditional approaches in mental health research apply General Linear Models (GLM) to describe the longitudinal dynamics of observed psycho-behavioral measurements (questionnaire summary scores). Similarly, GLMs are also applied characterize relationships between neurobiological (regional fMRI signals) and perceptual stimuli or other regional signals. While these methods useful for exploring linear correlations among isolated signals those constructs (i.e., scores signals), classical...
<title>Abstract</title> <bold>Objective:</bold> White matter hyperintensities (WMH) on brain MRI images are the most common feature of cerebral small vessel disease (CSVD). Studies have yielded divergent findings modifiable risk factors for WMH and WMH’s impact cognitive decline. Mounting evidence suggests sex differences in burden subsequent effects cognition. Thus, we aimed to identify sex-specific WMH. We then explored whether there were associations longitudinal clinical dementia...
We collected two-photon line-scans along brain capillaries in Alzheimer's and wildtype mice. applied Radon transform to quantify red blood cell velocity found it decreasing with increased cerebral amyloid angiopathy but not tissue plaques.
The white matter (WM) network integrity is assumed to associate with Alzheimer's disease (AD)-related gray (GM) atrophy. To investigate this hypothesis, we estimated WM-specific brain age quantify WM and calculated twelve AD-related GM signatures in a longitudinal cognitively normal cohort. We identified that the change rate of was significantly correlated left hippocampal amygdala volumetric changes; is, accelerated aging associated more atrophic volumes. This result suggested changes...
A 3D printed re-usable box enclosure and two-piece cutting guide were developed to produce high quality 7T MR images that can be easily registered gross anatomy histology. Cuts made parallel or at multiple angles 5mm intervals in both the axial coronal orientations.
We present a comprehensive ex-vivo brain ultra-high field MRI workflow that addresses transmit magnetic in-homogeneities without the need to build dedicated coil. Additionally, we show 7T T1w with high quality grey white matter contrast is feasible MP2RAGE .
<p dir="ltr">White matter hyperintensity (WMH) lesions on brain MRI images are surrogate markers of cerebral small vessel disease (CSVD). Longitudinal studies examining the association between diabetes and WMH progression have yielded mixed results. Thus, in this study we investigated HbA1c, a biomarker for presence severity hyperglycemia, longitudinal change after adjusting known risk factors progression. We recruited 64 participants from South Korean memory clinics to undergo at...
The ability to continuously prototype and 3D print new containers as well using an improved transmit coil has led major improvements in ex-vivo image quality. This also allowed for a more automated registration process of the MR images gross anatomy
Abstract Background Glymphatic clearance dysfunction within the perivascular space has been implicated in Alzheimer's Disease (AD) pathology. Diffusion MRI‐based techniques such as DTI‐ALPS can quantify interstitial fluid (ISF) dynamics, yet their links with other early AD markers cognitively normal elderly population remain underexplored. Here, we investigated associations between and cerebral β‐amyloid (Aβ) burden measured Pittsburgh Compound B (PiB)‐PET. We also evaluated an augmented...
Abstract Background Glymphatic clearance dysfunction within the perivascular space has been implicated in Alzheimer’s Disease (AD) pathology. Diffusion MRI‐based techniques such as DTI‐ALPS can quantify interstitial fluid (ISF) dynamics, yet their links with other early AD markers cognitively normal elderly population remain underexplored. Here, we investigated associations between and cerebral ß‐amyloid (Aß) burden measured Pittsburgh Compound B (PiB)‐PET. We also evaluated an augmented...
Abstract Background Functional MRI (fMRI) studies have associated impaired memory networks with increase in AD pathology. Recently, cross‐sectional analyses found b‐amyloid (Aβ) deposition different patterns of hippocampal connectivity a task based on sex and white matter hyperintensity volume (WMHV). However, don’t provide insight into the driving mechanisms network change. In this longitudinal study, we identify risk factors that are changes. Method Our study included 54 cognitively normal...
Abstract Background In this study we evaluated age‐ and sex‐associated morphological changes of cerebral blood vessels using 7T Time‐of‐flight (TOF) magnetic resonance angiography (MRA). Method Our consisted 25 cognitively normal older adults (20 female, mean age 68.2 years). Whole‐Brain TOF MRA images were collected on a Siemens scanner at the University Pittsburgh (slice number = 354, voxel size 0.38*0.38*0.38 mm, 12 mins). An iterative vessel segmentation algorithm, VesselMapper, was used...
Abstract Background In this study we evaluated age‐ and sex‐associated morphological changes of cerebral blood vessels using 7T Time‐of‐flight (TOF) magnetic resonance angiography (MRA). Method Our consisted 25 cognitively normal older adults (20 female, mean age 68.2 years). Whole‐Brain TOF MRA images were collected on a Siemens scanner at the University Pittsburgh (slice number = 354, voxel size 0.38*0.38*0.38 mm, 12 mins). An iterative vessel segmentation algorithm, VesselMapper, was used...
Abstract Background White matter hyperintensities (WMHs) are neuroimaging features associated with Alzheimer’s disease (AD). Ex‐vivo studies may enable better characterization of WMHs pathological substrates. In this work, we present a novel method that leverages in‐vivo and ex‐vivo MRIs histopathology to analyze the progression in AD. Method A single subject’s MRI scans at four different time points were analyzed. brain left hemisphere done using 16‐Tx 32‐Rx TicTacToe coil 3 3‐D printed...