A5087354864- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Ocular Infections and Treatments
- Glaucoma and retinal disorders
- Ocular Oncology and Treatments
- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Ocular Diseases and Behçet’s Syndrome
- Advanced Drug Delivery Systems
- Allergic Rhinitis and Sensitization
- Acne and Rosacea Treatments and Effects
- Retinal Diseases and Treatments
- Skin Protection and Aging
- Botulinum Toxin and Related Neurological Disorders
- Olfactory and Sensory Function Studies
- Cerebral Venous Sinus Thrombosis
- Traffic and Road Safety
- Cervical Cancer and HPV Research
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Ophthalmology and Visual Impairment Studies
- Ophthalmology and Eye Disorders
- Bacterial Identification and Susceptibility Testing
- Immunotherapy and Immune Responses
- Ocular Disorders and Treatments
Florida Eye Microsurgical Institute
2006-2022
Louisiana State University
2011
To compare the intraocular pressure (IOP)-lowering efficacy and safety of netarsudil once daily (QD) timolol twice (BID).Double-masked, randomized, phase 3, noninferiority study.Patients with open-angle glaucoma or ocular hypertension (unmedicated baseline IOP >20 to <30 mm Hg at 8:00 AM) were randomized ophthalmic solution 0.02% QD (PM) 0.5% BID. The primary endpoint was mean AM, 10:00 4:00 PM week 2, 6, month 3 in patients <25 (per-protocol population). Safety recorded over 6-month...
PurposeTo evaluate the safety and efficacy of OTX-101, a novel aqueous nanomicellar formulation cyclosporine (0.09%), in treatment patients with dry eye disease (DED).DesignA randomized, multicenter, vehicle-controlled, double-masked, phase 3 clinical trial.ParticipantsAdults (18–90 years age) history diagnosis DED, global symptom score 40 or more (range, 0–100), lissamine green conjunctival staining 9 less 0–12) at least 1 eye.MethodsEligible entered run-in period 14 to 20 days which all...
The aim of this study was to evaluate the safety and efficacy OTX-101, a clear nanomicellar aqueous solution cyclosporine, in treatment dry eye disease (DED).This 12-week multicenter, randomized, prospective, double-masked, vehicle-controlled, dose-ranging clinical trial. Subjects were adults aged ≥18 years, with total conjunctival staining score ≥3 ≤9, global DED symptom ≥40 (0-100 visual analogue scale). Following 14-day vehicle run-in, subjects randomized 1:1:1 ratio twice daily OTX-101...
Purpose. To evaluate topical interferon alpha-2b (IFNα2b) as a lone therapy in the treatment of primary conjunctival and corneal intraepithelial neoplasia (CIN). Methods. Noncomparative, prospective, interventional case series. Seven patients from three institutions, treated between February October 1999, with presumed CIN lesions (clinically diagnosed by specialists) were given IFNα2b drops (1 million units/mL) four to six times daily. Follow-up was performed biweekly until there complete...
Keratoconjunctivitis sicca affects 5% to 33% of the population and is often accompanied by symptoms such as burning dryness. This pooled analysis evaluated total central corneal fluorescein staining (CFS) in patients receiving OTX-101 0.09% or vehicle phase 2b/3 3 studies whether improvements correlated with improved visual acuity.In these randomized, vehicle-controlled studies, received 1 drop both eyes twice daily. Corneal was performed at baseline days 28, 56, 84. CFS each zone (0-to-4...
To evaluate endothelial cell survival 2 years after Descemet-stripping automated keratoplasty (DSAEK) for the treatment of dysfunction in presence an anterior chamber intraocular lens (AC IOL).LSU Eye Center, New Orleans, Louisiana, and Florida Microsurgical Institute, Boynton Beach, Florida, USA.Case series.This study comprised eyes with failure that had DSAEK AC IOL. Donor central density (ECD) was recorded 6 months, 1 year, postoperatively compared preoperative ECD eye-bank values.The...
To measure the outcomes of primary pterygium excision with a limbal conjunctival autograft when combined adjunctive use prophylactic subconjunctival graft amniotic membrane to decrease recurrence rate after surgery in an ethnically diverse population statistically higher risk for (African American, Asian, Caribbean, Latin).This is retrospective, non-comparative study post-operative outcomes.A total 355 patients, totaling 493 eyes, clinically significant, pterygia.Patients were enrolled into...
Purpose: The objective of this study was to collect and evaluate retrospective safety information about the use besifloxacin ophthalmic suspension 0.6% for treatment bacterial keratitis. Methods: This a retrospective, postmarketing surveillance conducted at 10 clinical centers in United States. population included 142 patients treated with keratitis one or both eyes. For perspective, data on 85 these moxifloxacin solution 0.5% were also included. analysis designed measure types rates adverse...
Purpose: Keratoconjunctivitis sicca (KCS), a multifactorial disease, is the most common ocular condition for patients seeking medical treatment and characterized by burning, stinging, dryness. This pooled analysis examined effect of OTX-101 0.09% versus vehicle on total individual conjunctival staining in with KCS from phase 2b/3 3 studies. Methods: In these randomized, multicenter, double-masked, vehicle-controlled studies, received 1 drop or both eyes twice daily. The time points were...
Background: OTX-101 is approved for treatment of keratoconjunctivitis sicca (KCS). We present results a phase 3 worse-eye efficacy analysis and 1-year safety extension. Methods: During the double-masked phase, patients with bilateral KCS were randomized 1:1 to 12 weeks or vehicle 1 drop per eye twice daily. Efficacy assessments included Schirmer's test corneal conjunctival staining. All who completed eligible enrollment in open-label extension received daily up 52 weeks. Safety endpoints...
Purpose: The aim of this study was to determine if the concomitant use ketorolac 0.4% and cyclosporin-A improves patient comfort during induction phase in treating chronic dry eye disease. Methods: Patients (n = 52) with clinically diagnosed were randomized receive either monotherapy twice-daily (BID) or a BID adjunctive regimen ketorolac, followed by instillation 10 min later. Study visits at baseline, week 2, 6. At each visit, patients underwent an evaluation for corneal staining,...
Understanding antibiotic resistance and toxin profiles among staphylococcal isolates in ocular infections can aid therapeutic management infection prevention strategies. We evaluated vitro patterns molecular traits of staphylococci isolated from patients with surface infections. also report on clinical outcomes for these following empirical treatment topical besifloxacin ophthalmic suspension 0.6%. This was a small observational study. Participating investigators three sites collected an...
Purpose: To report an eye-threatening complication associated with amniotic membrane grafting. Design: Interventional case report. Methods: Retrospective review of the clinical and surgical records a 43-year-old man who developed melting his corneal graft after transplantation. Results: Melting transplantation was arrested by utilizing tectonic, full-thickness button denuded endothelium in conjunction temporary tarsorraphy systemic steroids. Conclusions: best our knowledge, this is first...
Abstract: Dry eye disease (DED) is a multifactorial disorder characterized by loss of tear film homeostasis, which initiates cycle ocular surface inflammation and damage. As discomfort symptoms associated with DED can decrease quality life, affected patients prefer treatments that rapidly improve the underlying process. OTX-101 0.09% (CEQUA ® ) indicated to increase production in DED. The current analysis assessed early efficacy adult bilateral evaluating endpoints after 14 days treatment...