A5087568390- Supramolecular Chemistry and Complexes
- Crystallography and molecular interactions
- Pesticide Residue Analysis and Safety
- Molecular Sensors and Ion Detection
- Crystallization and Solubility Studies
- Synthetic Organic Chemistry Methods
- Synthesis and Catalytic Reactions
- Analytical Chemistry and Chromatography
- Contact Dermatitis and Allergies
- X-ray Diffraction in Crystallography
- Pharmacological Effects and Assays
- Selenium in Biological Systems
- Cyclone Separators and Fluid Dynamics
- Heavy Metal Exposure and Toxicity
- Organometallic Compounds Synthesis and Characterization
- Oxidative Organic Chemistry Reactions
- Spacecraft and Cryogenic Technologies
- Inflammatory mediators and NSAID effects
- Mycotoxins in Agriculture and Food
- Porphyrin and Phthalocyanine Chemistry
- Crystal structures of chemical compounds
- Plant and fungal interactions
- Lichen and fungal ecology
- Agricultural safety and regulations
- Silicone and Siloxane Chemistry
Center for Food Safety and Applied Nutrition
2014-2019
United States Food and Drug Administration
2014-2019
University of Maryland, College Park
2011-2013
Leibniz University Hannover
1998-2000
We report that the p-xylylenediammonium ion (11) acts as a template in cucurbit[n]uril forming reaction biases toward production of methylene bridged glycoluril hexamer (6C) and bis-nor-seco-CB[10]. Hexamer 6C is readily available on gram scale by one step synthetic procedure avoids chromatography. undergoes macrocylization with (substituted) phthalaldehydes 12, 14, 15, 18-in 9 M H(2)SO(4) or concd HCl at room temperature to deliver monofunctionalized CB[6] derivatives 13, 16, 17, 19-that...
Climbing the cucurbit ladder: Cucurbit[6]uril dimers (connected gray cylinders; see scheme) were prepared by condensation of glycoluril hexamer with appropriate tetraaldehydes. The self-assembly process between these and oligoviologen compounds (blue) in water leads to a supramolecular ladder dimensions molecular weight typical small proteins. cucurbit[n]uril (CB[n]; n=5, 6, 7, 8, 10) family1 containers have become object intense focus field chemistry over past decade.2 This surge interest...
This paper describes the synthesis of host 1 by double bridging reaction bis-ns-CB[10] with 2 under acidic conditions. Host functions as a cavity for aliphatic and aromatic ammonium ions (3–17) in water. Conducting presence guest 4 delivers [3]rotaxane 1·42 clipping process.
Ultrahigh-performance liquid chromatography using positive electrospray ionization and quadrupole orbital ion trap high-resolution mass spectrometry was evaluated for analyzing mycotoxins in finished cereal nut products. Optimizing the analyzer full-scan mode mycotoxin-fortified matrix extracts gave accuracies, δM, of <±2.0 ppm at 70 000 full width half maximum (FWHM) resolution (RFWHM). The limits quantitation were matrix- mycotoxin-dependent, ranging from 0.02 to 11.6 μg/kg. Mean...
An analytical method was developed and validated for the determination of 40 veterinary drugs in various milk-based powders. The involves acetonitrile/water extraction, solid-phase filtration lipid removal fat-containing matrices, analysis using liquid chromatography–tandem mass spectrometry (LC-MS/MS). limits quantitation (LOQ) ranged from 0.02 to 82 ng/g. Acceptable recoveries (70–120%, RSD < 20%) were reached 52 target compounds at three fortification levels nonfat milk powder. Similar...
Isothiazolinone biocides are broad‐spectrum preservatives that widely used in cosmetics, household, and industrial products. An increase the number of cases allergic contact dermatitis to isothiazolinone preservatives, namely, methylisothiazolinone methylchloroisothiazolinone, have been recently noticed. The Food Drug Administration relies on analytical methods quantify levels use cosmetic ingredients support enforcement action against products not compliance with law. In this study, an...
Recently, we reported the synthesis of two new dimeric cucurbit[6]uril compounds (1 and 2). Herein, describe ability compound 1 to undergo supramolecular polymerisation when combined with polyethylene glycol (PEG) derived divalent guests 3MW (MW = 300, 1000, 3350, 10,000). Interestingly, find that shorter PEG-derived 3300, 31000 33350 lead low degrees oligomerisation based on diffusion coefficients obtained by diffusion-ordered spectroscopy measurements. In contrast, was longest guest...
Crystal structure of l,8-dimethyl-7a-methoxy-10a-(triisopropylsilyloxy)-(2ß) -12-oxatricyclo[6.3.1.
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