A5108286444- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Advanced biosensing and bioanalysis techniques
- COVID-19 Clinical Research Studies
- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- COVID-19 diagnosis using AI
- Herpesvirus Infections and Treatments
- Biosensors and Analytical Detection
- Dental Research and COVID-19
- Respiratory viral infections research
- Zoonotic diseases and public health
- Plant Virus Research Studies
- COVID-19 Impact on Reproduction
- T-cell and Retrovirus Studies
- Nuclear Receptors and Signaling
- Allergic Rhinitis and Sensitization
- Long-Term Effects of COVID-19
- Pregnancy and preeclampsia studies
- Maternal Mental Health During Pregnancy and Postpartum
Universidade Federal do Rio de Janeiro
2021-2024
Abstract ACE2 and TMPRSS2 are key players on SARS-CoV-2 entry into host cells. However, it is still unclear whether expression levels of these factors could reflect disease severity. Here, a case–control study was conducted with 213 positive individuals where cases were defined as COVID-19 patients respiratory distress requiring oxygen support (N = 38) controls those mild to moderate symptoms the who did not need therapy along entire clinical course 175). mRNA evaluated in nasopharyngeal...
Community testing is a crucial tool for the early identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission control. The emergence highly mutated Omicron variant (B.1.1.529) raised concerns about its primary site replication, impacting sample collection detectability by rapid antigen tests. We tested performance Panbio diagnostic test (Ag-RDT) using nasal oral specimens COVID-19 diagnosis in 192 symptomatic individuals, with quantitative...
There are some reports and case series addressing Coronavirus Disease 2019 (COVID-19) infections during pregnancy in upper income countries, but there few data on pregnant women with comorbid conditions low middle Countries. This study evaluated the proportion maternal neonatal outcomes associated SARS-CoV-2 infection among comorbidities. Participants were recruited consecutively order of admission to a maternity for Sociodemographic, clinical, laboratory prospectively collected...
Current guidelines for patient isolation in COVID-19 cases recommend a symptom-based approach, averting the use of control real-time reverse transcription PCR (rRT-PCR) testing. However, we hypothesized that patients with persistently positive results by RT-PCR severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be potentially infectious prolonged time, even if immunocompetent and asymptomatic, which would demand longer social period than presently recommended. To test this...
Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) transmission occurs even among fully vaccinated individuals; thus, prompt identification of infected patients is central to control viral circulation. Antigen rapid diagnostic tests (Ag-RDTs) are highly specific, but sensitivity variable. Discordant RT-qPCR vs. Ag-RDT results reported, raising the question whether negative in positive samples could imply absence infectious viruses. To study relationship between with...
BACKGROUND In 2022, an outbreak of mpox that started in European countries spread worldwide through human-to-human transmission. Cases have been mostly mild, but severe clinical presentations reported. these cases, tecovirimat has the drug choice to treat patients with aggravated disease. OBJECTIVES Here we investigated susceptibility 18 isolates monkeypox virus (MPXV) obtained from different regions Brazil. METHODS Different concentrations were added cell monolayers infected each MPXV...
BACKGROUND The high demand for adequate material the gold standard reverse transcription real-time polymerase chain reaction (RT-qPCR)-based diagnosis imposed by Coronavirus disease 2019 (COVID-19) pandemic, combined with inherent contamination risks healthcare workers during nasopharyngeal swab (NP) sample collection and discomfort it causes patients, brought need to identify alternative specimens suitable of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). OBJECTIVES aim this...
Mpox is a zoonotic disease historically reported in Africa. Since 2003, limited outbreaks have occurred outside In 2022, the global spread of cases with sustained interhuman transmission and unusual features raised public health concerns. We explore mpox outbreak Rio de Janeiro (RJ) state, Brazil, an observational study mpox-suspected from June to December 2022. Data collection relied on healthcare notification form. Diagnosis was determined by MPXV-PCR. 46 confirmed cases, anti-VACV IgG...
Abstract New SARS-CoV-2 variants are continually emerging and have the potential to present challenges public health responses worldwide. This report discusses early detection of lineage JN.2.5 (alias B.1.1.529.2.86.1.2.5) in Rio de Janeiro, Brazil. The variant was identified 2024 through viral whole-genome sequencing phylogenetic analysis, revealing that circulating strains genetic similarities sequences reported Canada, Poland, Belgium, England. While circulation diverse Omicron sub...
Background The diagnosis of allergic rhinitis (AR) is based on clinical manifestations and supported by a positive result for skin prick test (SPT) or serum specific immunoglobulin E (sIgE) antibodies to aeroallergens. Our objective was investigate the frequency patients with AR without evidence IgE sensitization.
Abstract SARS-CoV-2 transmission occurs even among fully vaccinated individuals; thus, prompt identification of infected patients is central to control viral circulation. Antigen rapid diagnostic tests (Ag-RDT) are highly specific, but sensitivity variable.Discordant RT-qPCR vs Ag-RDT results reported, raising the question whether negative in positive samples could imply absence infectious viruses. To study relationship between a with virological, molecular, and serological parameters, we...
Abstract Community testing is a crucial tool for the early identification of SARS-CoV-2 infection and transmission control. The emergence highly mutated Omicron variant (B.1.1.259) raised concerns about its primary site replication, impacting sample collection, detectability by rapid antigens tests. We tested Antigen Rapid Diagnostic Test (Ag-RDT) performance using nasal, oral, saliva specimens COVID-19 diagnosis in 192 symptomatic individuals, RT-qPCR from nasopharyngeal samples as Variant...