A5052648177- Enzyme Structure and Function
- Analytical Chemistry and Chromatography
- Computational Drug Discovery Methods
- Chemical Thermodynamics and Molecular Structure
- Crystallization and Solubility Studies
- Mass Spectrometry Techniques and Applications
- Plant biochemistry and biosynthesis
- Crystallography and molecular interactions
- Protein Structure and Dynamics
University of Gothenburg
2019-2025
AstraZeneca (Sweden)
2019-2025
Structure-based drug design is highly dependent on the availability of structures protein interest in complex with lead compounds. Ideally, this information can be used to guide chemical optimization a compound into pharmaceutical candidate. A limitation main structural method today - conventional X-ray crystallography that it only provides about its frozen state. Serial relatively new approach offers possibility study at room temperature (RT). Here, we explore use serial determine target,...
Serial crystallography is having an increasing impact on structural biology. This emerging technique opens up new possibilities for studying protein structures at room temperature and investigating dynamics using time-resolved X-ray diffraction. A limitation of the method intrinsic need large quantities well ordered micrometre-sized crystals. Here, a presented to screen conditions that produce microcrystals membrane proteins in lipidic cubic phase well-based crystallization approach. key...
Abstract Structure-based drug design is highly dependent on the availability of structures protein interest in complex with lead compounds. Ideally, this information can be used to guide chemical optimization a compound into pharmaceutical candidate. A limitation main structural method today, rotational cryo-crystallography, that it only provides protein-complex its frozen state. Serial crystallography relatively new approach offers possibility study at room-temperature. Here, we explore use...