A5040070829- Virology and Viral Diseases
- Viral Infections and Vectors
- Respiratory viral infections research
- Mosquito-borne diseases and control
- HIV Research and Treatment
- interferon and immune responses
- vaccines and immunoinformatics approaches
- Influenza Virus Research Studies
- Plant Virus Research Studies
- Teacher Education and Leadership Studies
- Polyomavirus and related diseases
- Platelet Disorders and Treatments
- Diverse Education Studies and Reforms
- Cytomegalovirus and herpesvirus research
- Animal Virus Infections Studies
- Vector-borne infectious diseases
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Vector-Borne Animal Diseases
- Rabies epidemiology and control
- Computational Drug Discovery Methods
- Bacteriophages and microbial interactions
Cornell University
2017-2025
Gilead Sciences (United States)
2025
New York State College of Veterinary Medicine
2019-2022
University of Kentucky
2021
Butte County Department of Behavioral Health
2018
Butte County Office of Education
2018
Washington State University
2016
The Paramyxoviridae family comprises important pathogens that include measles (MeV), mumps, parainfluenza, and the emerging deadly zoonotic Nipah virus (NiV) Hendra (HeV). Paramyxoviral entry into cells requires viral-cell membrane fusion, formation of paramyxoviral pathognomonic syncytia cell-cell fusion. Both events are coordinated by intricate interactions between tetrameric attachment (G/H/HN) trimeric fusion (F) glycoproteins. We report receptor binding induces conformational changes in...
As new SARS-CoV-2 variants continue to emerge, it is important evaluate the potency of antiviral drugs support their continued use. Remdesivir (RDV; VEKLURY®) an approved treatment for COVID-19, and obeldesivir (ODV) are inhibitors RNA-dependent RNA polymerase Nsp12. Here we show these two compounds retain activity against Omicron BA.2.86, BF.7, BQ.1, CH.1.1, EG.1.2, EG.5.1, EG.5.1.4, FL.22, HK.3, HV.1, JN.1, JN.1.7, JN.1.18, KP.2, KP.3, LB.1, XBB.1.5, XBB.1.5.72, XBB.1.16, XBB.2.3.2,...
Abstract Background Remdesivir (RDV), a nucleotide analog prodrug that targets the viral RNA-dependent RNA polymerase, Nsp12, is approved to treat COVID-19 in hospitalized and nonhospitalized patients. Obeldesivir (ODV), an oral mono-5’-isobutyryl ester prodrug, metabolized into same active triphosphate as RDV. The antiviral activity of RDV ODV against previous Omicron subvariants (BA.1 XBF) was maintained with respect ancestral WA1 strain. Here, data recent (XBB.2.3.2, EG.5.1, EG.1.2,...
Nipah and Hendra viruses (NiV HeV) exhibit high lethality in humans are biosafety level 4 (BSL-4) paramyxoviruses the growing genus Henipavirus The attachment (G) fusion (F) envelope glycoproteins both required for viral entry into cells cell-cell fusion, which is pathognomonic of henipaviral infections. Here, we compared fusogenic capacities between homologous heterologous pairs NiV HeV glycoproteins. Importantly, to accurately measure their capacities, as these depend on glycoprotein cell...
Respiratory syncytial virus (RSV) is a significant cause of morbidity and mortality in high-risk populations. Although prophylactic options are available, there no effective oral therapeutics for RSV infection. Obeldesivir (ODV) an orally bioavailable prodrug the nucleoside analog GS-441524, which converted intracellularly to its active triphosphate inhibits RNA polymerase. Here we report potent antiviral activity ODV against geographically temporally diverse A B clinical isolates (EC 50 :...
Nipah virus is a zoonotic biosafety level 4 agent with high mortality rates in humans. The genus to which belongs, Henipavirus , includes five officially recognized pathogens; however, over 20 species have been identified multiple continents within the last several years. As there are still no vaccines or treatments for NiV infection, elucidating its process of viral particle production imperative both targeted drug design as well particle-based vaccine development. Developments...
Cholesterol has been implicated in various viral life cycle steps for different enveloped viruses, including entry into host cells, cell-cell fusion, and budding from infected cells. Enveloped viruses acquire their membranes Although cholesterol associated with the binding of cholesterol's exact function viral-cell membrane fusion process remains largely elusive, particularly paramyxoviruses. Furthermore, paramyxoviral occurs at cell is essential both virus (virus-cell fusion) syncytium...
This article emerges from the collaborative work of Hispanic-Serving Institution (HSI) scholars and administrators. From their perspectives as acting HSI leaders, authors examine research/programs/practices [relevant to institutions] pertaining attracting, preparing, employing, retaining Latina/o/x/Hispanic teachers. Research programs noted here identify challenges, facilitators, recommendations for improving educational outcomes increasing number Increasing teachers involves processes that...
Medically important paramyxoviruses, such as measles, mumps, parainfluenza, Nipah, and Hendra viruses, infect host cells by directing fusion of the viral cellular plasma membranes. Upon infection, paramyxoviruses cause a second type membrane fusion, cell-cell (syncytium formation), which is linked to pathogenicity. Host cell receptor binding causes conformational changes in attachment glycoprotein (HN, H, or G) that trigger cascade (F) mediates fusion. F, class I protein, contains archetypal...
Nipah virus (NiV) is a zoonotic bat henipavirus in the family Paramyxoviridae NiV deadly to humans, infecting host cells by direct fusion of viral and cell plasma membranes. This membrane process coordinated receptor-binding attachment (G) (F) glycoproteins. Upon G-receptor binding, F fuses membranes via cascade that sequentially involves F-triggering, pore formation, or genome entry into cells. Using as an important paramyxoviral model, we identified two novel regions modulate cascade. For...
Abstract Enveloped viruses can cause devastating zoonotic diseases and are the most likely to global pandemics. We identified a new class of small-molecule sulfur-containing antiviral compounds (XM series) that broadly inhibit enveloped viruses. The antivirals’ mechanism action was explored via various multidisciplinary approaches, concluding XM antivirals alter membrane lipid chemical compositions, increase order deep within hydrophobic region bilayer, phase transition temperatures. Such...
Hendra virus (HeV) is a zoonotic enveloped member of the family Paramyoxviridae. To successfully infect host cell, HeV utilizes two surface glycoproteins: attachment (G) protein to bind, and trimeric fusion (F) merge viral envelope with membrane cell. The transmembrane (TM) region F has been shown have roles in stability overall association F. Previously, alanine scanning mutagenesis performed on C-terminal end protein, revealing importance β-branched residues this region. Additionally, S490...