A5101669120- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
International Peace Maternity & Child Health Hospital
2020
Shanghai Jiao Tong University
2020
Serous ovarian carcinomas (SCA) are the most common and aggressive carcinoma subtype which etiology remains unclear. To investigate prospective role of mRNAs in tumorigenesis progression SCA, aberrantly expressed were calculated based on NCBI-GEO RNA-seq data. Of 21,755 genes with 89 SCA SBOT cases from 3 independent laboratories, 59 identified as differentially (DEGs) (|log2Fold Change| > 1.585, also |FoldChange| adjusted P < 0.05) by DESeq R. There 26 up-regulated DEGs 33 down-regulated...
Lung adenocarcinoma (LUAD) comprises around 40% of all lung cancers, and in about 70% patients, it has spread locally or systemically when first detected leading to a worse prognosis.We filtered out differentially expressed genes (DEGs) based on the RNA sequencing data Gene Expression Omnibus database verified deeply analyzed screened DEGs using combined bioinformatics approach.Expressions 11,143 694 nontumor tissues LUAD cases from 8 independent laboratories were analyzed; 188 mRNAs...