A5012957352- Gastrointestinal motility and disorders
- Pathogenesis and Treatment of Hiccups
- Epigenetics and DNA Methylation
- Antibiotic Resistance in Bacteria
- Complementary and Alternative Medicine Studies
- Genetic factors in colorectal cancer
- Infant Health and Development
- Pain Management and Placebo Effect
- Amoebic Infections and Treatments
- Parasitic Infections and Diagnostics
- Phytochemistry and biological activity of medicinal plants
- Pneumonia and Respiratory Infections
- Health and Well-being Studies
- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- Pharmacological Effects of Natural Compounds
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Infections and bacterial resistance
- Hedgehog Signaling Pathway Studies
- Moringa oleifera research and applications
- Digestive system and related health
- Essential Oils and Antimicrobial Activity
- Cancer-related molecular mechanisms research
Shiraz University of Medical Sciences
2014-2024
Background. Ulcerative colitis is a worldwide chronic gastrointestinal disease characterized by variable extensions of colon mucosal inflammation. The available drugs have an incomplete response with various side effects and socioeconomic impacts. Aloe barbadensis Miller (Aloe vera) well-known medicinal plant diverse pharmacological therapeutic activities. As result, in the current study, vera was selected to evaluate its on experimental rats. Methods. This study intended possible beneficial...
Hypervirulent Klebsiella pneumoniae (hvKp) pathotype is emerging worldwide in pyogenic liver abscesses (PLAs). However, the role of virulence factors pathogenicity remains unclear. On other hand, epidemiology PLAs Iran unknown. From July 2020 to April 2022, bacterial species were isolated and identified from drainage samples 54 patients with PLAs. K. as most common pathogen was 20 (37%) patients. We analyzed clinical microbiological characteristics -related abscesses. Antibiotic...
Abstract Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections are a major public health problem, necessitating the administration of polymyxin E (colistin) as last-line antibiotic. Meanwhile, mortality rate associated with colistin-resistant K. is seriously increasing. On other hand, importance carbapenems in promoting colistin resistance unknown. Case presentation We report case -related pyogenic liver abscess which susceptible transformed into carbapenem- and during...
Inflammatory bowel disease (IBD) is a strongly associated with colorectal cancer (CRC) as well-known precancerous condition. Alterations in DNA methylation and mutation K-ras are believed to play an early etiopathogenic role CRC may also initiating event through deregulation of molecular signaling. Epigenetic silencing APC SFRP2 the WNT signaling pathway be involved IBD-CRC. The aberrant state under intensive investigation worldwide. aim this study was investigate status promoter MGMT-B,...
Ulcerative colitis is a common subtype of persistent inflammatory bowel disease with high morbidity consequences. Despite unknown definite pathogenesis, multiple anti-inflammatory medications are used for its treatment. Traditionally, Quercus brantii (QB), mostly available in the Middle East, has been gastrointestinal disorders. Other beneficial effects associated QB include reduction oxidative stress, inflammations, homeostatic instability, and improvement clinical conditions.This...
The pathogenesis of sporadic colorectal cancer (CRC) is influenced by the patient genetic background and environmental factors. Based on prior understanding, these are classified in two major pathways instability. Microsatellite instability (MSI) CPG island methylator phenotype (CIMP) categorized as features hypermethylated prototype, chromosomal (CIN) known to be indicative non-hypermethylated category. Secreted frizzled related protein 2 (SFRP2), APC1A WNT signaling pathway DNA repair...
Background: Irritable bowel syndrome (IBS), as a chronic digestive disorder, impacts extensively on the quality of life, emotional well-being and self-identity.Chronic illness disrupts taken-for-granted notions about self.No qualitative study was found regarding patients' experience life with irritable (IBS) in Iran.Objective: To explore self-perception lived IBS patients.Methods: A hermeneutic phenomenological approach conducted 12 patients who had been referred to three central clinics (2...
Objectives: In this study, psychology evaluation was performed for a population of patients with functional bowel disorders. Patients and Methods: One hundred disorders including 50 irritable syndrome (IBS) referred to GI clinics were candidates psychiatry evaluation; those 60 completed the study. Psychiatric diagnosed using structured clinical interview based on diagnostic statistical manual mental IV (DSM IV). Results: Of (including 39 IBS), 51 (85%) at least one disorder. The most common...
The current study aimed to determine the effects of hypnotism on severity gastrointestinal symptoms and quality life in individuals with irritable bowel syndrome (IBS). This trial was conducted 100 people IBS Shiraz, Iran. Hypnotism participants performed 1-hour sessions for intervention group at Weeks 4 6. A demographic characteristic questionnaire, Gastrointestinal Symptom Rating Scale, Quality Life Index were used data collection. significantly improved 6 15 weeks after hypnotherapy....
Background: Colorectal cancer is the third most common in world and forth cause of death by globally. starts with a polyp might develop due to multiple epigenetic genetic changes that lead change normal colon epithelium adenocarcinoma colon. Recent studies show such as methylation SFRP2 (secreted frizzled-related2) gene negative regulation Wnt signaling pathways MGMT (methylguanine-DNA methyltransferase) DNA repair associated colorectal cancer. Objectives: Due correlation cancer, current...
Objective. Research on the nature of living with Irritable Bowel Syndrome. Methods. Qualitative study hermeneutical phenomenology, which conducted in-depth semi-structured interviews people trained irritable bowel syndrome. The sampling was intentional type and open questions were used to collect data. Thematic Analysis Method by Van Manen used. Results. Two principal themes five subthemes emerged in this research determine meaning syndrome: Storm corporality (body pain affliction, tension...