A5040777151- Dementia and Cognitive Impairment Research
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Schizophrenia research and treatment
- Cardiac Imaging and Diagnostics
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Adolescent and Pediatric Healthcare
- Mental Health Treatment and Access
- Electroconvulsive Therapy Studies
- Mental Health and Psychiatry
- Family Caregiving in Mental Illness
- Curcumin's Biomedical Applications
- Pathogenesis and Treatment of Hiccups
- Cardiovascular Health and Disease Prevention
- Advancements in PLL and VCO Technologies
- Augmented Reality Applications
- Child Nutrition and Feeding Issues
- CCD and CMOS Imaging Sensors
- Fatty Acid Research and Health
- Nausea and vomiting management
- Electrolyte and hormonal disorders
- Interactive and Immersive Displays
QIMR Berghofer Medical Research Institute
2022
Medical Research Council
2022
University of Cambridge
2022
Cambridge University Hospitals NHS Foundation Trust
2022
UNSW Sydney
2016-2022
Black Dog Institute
2018-2020
Prince of Wales Hospital
2018-2020
St. Paul's Hospital
2017
Chinese University of Hong Kong
1997-2010
Hong Kong Polytechnic University
2000-2004
Abstract Background More validated instruments for assessment of behavioral and psychological symptoms dementia are required to facilitate local research. Method The psychometric properties the Chinese version neuropsychiatric inventory (CNPI) were tested in a sample 62 outpatients. concurrent validity was by measuring Spearman correlation between CNPI subscales with appropriate BEHAVE‐AD Hamilton rating scale depression (CHDS). internal consistency reliability, false‐negative rates...
Abstract Background Behavioural and psychological symptoms (BPSD) are common during the course of dementia present severe problems to patients their caregivers. Objectives To assess therapeutic efficacy safety haloperidol risperidone in treating BPSD Chinese patients. Methods A 12‐week double‐blind randomised comparison treatments was conducted 58 with DSM‐IV diagnosis Alzheimer's type or vascular dementia. They were randomly assigned receive flexible doses (0.5 2 mg/day) risperidone....
Abstract Background The prevalence of Alzheimer's disease is similar across ethnic groups. To our knowledge, no comparison behavioral symptoms has been addressed. Objective This cross‐sectional, retrospective, descriptive study compares neuropsychiatric Chinese subjects with (AD) at tertiary care centers in Taiwan and Hong Kong against Caucasian Los Angeles, California. We compared the frequency severity caregiver responses to AD using Neuropsychiatric Inventory (NPI). hypothesized that...
Emerging evidence suggests that psychiatric disorders are associated with disturbances in structural brain networks. Little is known, however, about networks those at high risk (HR) of bipolar disorder (BD), such carrying substantial predictive and etiological value. Whole-brain tractography was performed on diffusion-weighted images acquired from 84 unaffected HR individuals least one first-degree relative BD, 38 young patients BD 96 matched controls (CNs) no family history mental illness....
Abstract Background In Chinese culture, extended family support, acceptance of age‐related cognitive changes and filial tradition caring for elders may decrease caregiver burden distress in the context dementia. Objective To study cross‐regional cross‐cultural differences symptom‐related due to behavioral problems American patients with Alzheimer's disease. Method Caregivers disease at Taipei Veterans General Hospital, Taiwan ( n = 89), University Hong Kong 31) UCLA Disease Research Center,...
Objective: Recent studies of patients with bipolar disorder or at high genetic risk reveal structural dysconnections among key brain networks supporting cognitive and affective processes. Understanding the longitudinal trajectories these across peak age range onset could inform mechanisms illness resilience. Methods: Longitudinal diffusion-weighted MRI phenotypic data were acquired baseline after 2 years in 183 individuals ages 12–30 two cohorts: 97 unaffected a first-degree relative (the...
Bipolar disorder (BD) is a familial psychiatric associated with frontotemporal and subcortical brain abnormalities. It unclear whether such abnormalities are present in relatives without BD, little known about structural trajectories those at risk.Neuroimaging was conducted baseline 2-year follow-up interval 90 high-risk individuals first-degree BD relative (HR), 56 participants no family history of mental illness who could have non-BD diagnoses. All 146 subjects were aged 12-30 years...
Abstract Objectives This study aims to examine the psychometric properties of Chinese version Alzheimer's disease behavioral pathology rating scale (CBehave‐AD) and profile patients with AD. Methods Seventy‐one subjects NINCDS‐ADRDA diagnosis probable possible AD were assessed for validation CBehave‐AD. A symptom frequency checklist, Blessed Roth dementia (CDS) Cantonese Mini‐Mental State Examination (CMMSE) used comparison. An extended sample 120 was then evaluated Results High correlations...
Objective: To examine associations between behavioral and psychological symptoms of dementia (BPSD), cognitive function clinical deterioration over 2 years.Methods: One hundred four Chinese subjects with late-onset Alzheimer's Disease (AD) who presented to psychogeriatric clinics were followed for an average 22.5 months. BPSD subgroups categorized by latent class analysis using the Neuropsychiatric Inventory. Comprehensive profiles performed Mattis Dementia Scale, Hong Kong List Learning...
Hyponatremia is an uncommon but widely reported complication of selective serotonin uptake inhibitors (SSRIs), and most the case reports involve elderly patients. The presentation usually that SIADH, underlying mechanism leading to syndrome poorly understood. Since use SSRIs becoming more popular among depressed patients because potentially serious consequence hyponatremia, psychiatrists should be alert development familiarize themselves with its diagnosis treatment. We report two who were...
Akathisia as a side-effect of metoclopramide has received increasing attention in consultation-liaison psychiatry recent years. A case metoclopramide-induced akathisia resulting suicide attempt is reported order to highlight the suffering such patients and factors that lead misdiagnosis.
To find out the prevalence of dementia with Lewy bodies (DLB) in an inpatient psychogeriatric population Hong Kong Chinese.Clinical notes all patients admitted to unit between 1 January and 31 December 2000 were reviewed retrieve information on various subtypes that have been diagnosed prospectively using NINCDS-ARDRA, NINDS-AIREN, CDLB DSM-IV by qualified senior psychogeriatricians.There only three cases 102 inpatients, giving a rate 2.9% over two-year period.The is remarkably lower than...