A5055157765- Monoclonal and Polyclonal Antibodies Research
- Protein purification and stability
- Immunotherapy and Immune Responses
- Viral Infectious Diseases and Gene Expression in Insects
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Cancer Immunotherapy and Biomarkers
- Drug-Induced Hepatotoxicity and Protection
- Curcumin's Biomedical Applications
- Glycosylation and Glycoproteins Research
- vaccines and immunoinformatics approaches
- Chemotherapy-induced organ toxicity mitigation
- T-cell and B-cell Immunology
- Long-Term Effects of COVID-19
- interferon and immune responses
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
Academic Center for Education, Culture and Research
2020-2025
Motamed Cancer Institute
2020-2025
Tarbiat Modares University
2019
Utrecht University
2014-2016
Alzahra University
2016
Interferons (IFNs) are a group of signaling cytokines, secreted by host cells to induce protection against various disorders. IFNs can directly impact on tumor or indirectly the immune system protect cells. The expression levels and its functions excellently modulated in way from probable toxicities caused extreme responses. efficacy anticancer therapies is correlated signaling. Although IFN involved induction antitumor responses, chronic stimulation pathway resistance antineoplasm...
Determining to what extent biophysical characteristics of aggregates affect immunogenicity therapeutic interferon beta-1b. Three recombinant human beta-1b (rhIFNβ-1b) samples with different levels generated by copper oxidation, thermal stress, or left untreated, as well Avonex(®) drug substance and Betaferon(®) product, were injected intraperitoneally in nontransgenic beta transgenic FVB/N mice 5 times per week for 3 weeks. Antibodies against measured using enzyme-linked immunosorbent assay....
Aggregation often occurs during manufacturing and storage of protein drugs. Detergents such as sodium dodecyl sulfate are commonly used to prevent aggregation but need be eliminated before final formulation for safety reasons. We studied the ability dodecylmaltoside (DDM), a nontoxic alkyl saccharide surfactant, reduce increase stability interferon beta-1b (IFN)-β-1b. An 8°C in Tm IFN-β-1b was observed when 0.1% DDM present solution. The absorption on hydrophobic surfaces enables surface...
Human serum albumin (HSA)-free formulation of Escherichia coli-derived human interferon beta (IFNβ-1b) with a high percentage monomeric protein and low immunogenicity is developed characterized in the current study. UV spectroscopy, fluorescence dynamic light scattering, sodium dodecyl sulfate polyacrylamide gel electrophoresis, Western blotting, Micro-Flow Imaging, resonant mass measurement, size exclusion, reversed-phase performance liquid chromatographies were applied to assess effect...
In this study, we have investigated the aluminium phosphide (ALP) toxicity on Renal Function and oxidative stress in kidney tissue of male rats possible protective role Curcumin nanoCurcumin against ALP-induced nephrotoxicity.